Results 81 to 90 of about 2,138,893 (293)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus [PDF]

, 2004
Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients’ sera.
Sallie M. Neill, Hughes, GJ, Ien Chan, Andrew P. South, Black, Martin M., Oyama, N, McGrath, John A., McGrath, J A, Kawakami, Y, Fenella Wojnarowska, John A. McGrath, Mepani, K, Balbir S. Bhogal, South, AP, South, A P, Chan, Ien, Kaneko, F, Kawakami, Yoshio, Chan, I, Kirti Mepani, South, Andrew P., Bhogal, BS, Neill, Sallie M., Oyama, Noritaka, Bhogal, B S, Noritaka Oyama, Bhogal, Balbir S., David D’Cruz, Neill, SM, Mepani, Kirti, McGrath, JA, Fumio Kaneko, Kaneko, Fumio, D'Cruz, David, Hughes, G J, D'Cruz, D, Martin M. Black, Graham J. Hughes, Neill, S M, Hughes, Graham J., Yoshio Kawakami, Wojnarowska, F, Black, MM, Black, M M, Wojnarowska, Fenella   +44 more
core   +1 more source

In vivo topology converts competition for cell-matrix adhesion into directional migration

Nature Communications, 2019
Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be converted into
Fernanda Bajanca, Nadège Gouignard, Charlotte Colle, Maddy Parsons, Roberto Mayor, Eric Theveneau   +5 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Autologous Versatile Vesicles‐Incorporated Biomimetic Extracellular Matrix Induces Biomineralization

, 2020
Restoring extracellular matrix (ECM) with supportive and osteoinductive abilities is of great significance for bone tissue regeneration. Current approaches involving cell-based scaffolds or nanoparticle-modified biomimic-ECM have been met with additional
Zhang, Yufeng, Shen, Kailun, Zhang, Xiaoxin, Xiao, Yin, Xiaoxin Zhang, Yufeng Zhang, Yan Wei, Rui Wang, Wang, Rui, Miron, Richard J, Kailun Shen, Wei, Yan, Shi, Miusi, Zhang, Jinglun, Richard J. Miron, Yin Xiao, Jinglun Zhang, Miusi Shi   +17 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The Bi-Functional Organization of Human Basement Membranes [PDF]

, 2013
The current basement membrane (BM) model proposes a single-layered extracellular matrix (ECM) sheet that is predominantly composed of laminins, collagen IVs and proteoglycans.
Paul Bernhard Henrich (430036), Manimalha Balasubramani, Marko Loparic (430035), Farhad Safi, Loparic Marko, Lim, Roderick, Loparic, Marko, Guy Uechi (430031), Guy Uechi, Mueller, David, Philipp Oertle, Roderick Lim (430034), Balasubramani, Manimalha, Roderick Lim, Marko Loparic, Safi, Farhad, Lim Roderick, Halfter Willi, Uechi Guy, Henrich Paul Bernhard, Halfter, Willi, Oertle, Philipp, Monnier Christophe, Safi Farhad, Uechi, Guy, Paul Bernhard Henrich, Farhad Safi (430033), Christophe Monnier, Willi Halfter (430027), Monnier, Christophe, Henrich, Paul Bernhard, Manimalha Balasubramani (430032), Balasubramani Manimalha, David Müller (430029), Christophe Monnier (430028), Müller, David, Oertle Philipp, Philipp Oertle (430030), Müller David, Willi Halfter, David Müller   +40 more
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cardiac extracellular matrix: a dynamic entity

, 2005
Understanding the regulation of the extracellular matrix of the heart is essential to understanding the chronic changes in heart function in disease states such as hypertension, heart failure, and diabetes.
Brown, Lindsay, Brown, L
core   +1 more source