Results 71 to 80 of about 2,138,893 (293)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
ColPTMScape: An open access knowledge base for tissue-specific collagen PTM maps
Matrix Biology PlusCollagen is a key component of the extracellular matrix (ECM). In the remodeling of ECM, a remarkable variation in collagen post-translational modifications (PTMs) occurs.
Ashutosh Joshi +4 more
doaj +1 more source
Biology Open, 2017 Activated fibroblasts are considered major drivers of fibrotic disease progression through the production of excessive extracellular matrix (ECM) in response to signals from damaged epithelial and inflammatory cells.
Omar S. Qureshi +10 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Engineering contractile myocardial tissue using extracellular matrix scaffolds [PDF]
, 2013 There is currently an overwhelming need for functional replacement of diseased or damaged cardiac tissue. Biologic based scaffolds are an attractive tissue engineering approach to cardiac repair because they avoid sensitization associated with homograft ...
Remlinger, Nathaniel
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The influence of the extracellular matrix on cell behaviour [PDF]
, 2009 Stem cell research has raised great interest in the scientific community as it has the potential to form multiple cell types and it is believed they hold the key to curing many diseases. However, there is a need for better understanding of how to control
Cooke, Michael John
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Extracellular Vesicles as Matrix Messengers
The extracellular matrix (ECM) is a dynamic, acellular framework that maintains homeostasis and supports the preservation of tissues’ structural integrity.
Poppa, Giuseppina +2 more
core +1 more source
Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix
, 2017 Spinal cord and peripheral nerve injuries require the regeneration of nerve fibers across the lesion site for successful recovery. Providing guidance cues and soluble factors to promote neurite outgrowth and cell survival can enhance repair.
Windebank, Anthony J +6 more
core +1 more source