Results 21 to 30 of about 192,244 (159)

3D mapping of native extracellular matrix reveals cellular responses to the microenvironment

Journal of Structural Biology: X, 2019
Cells and extracellular matrix (ECM) are mutually interdependent: cells guide self-assembly of ECM precursors, and the resulting ECM architecture supports and instructs cells.
Zipora Lansky, Yael Mutsafi, Lothar Houben, Tal Ilani, Gad Armony, Sharon G. Wolf, Deborah Fass   +6 more
doaj   +1 more source

Imaging the Extracellular Matrix in Prevalent Cardiovascular Diseases

Applied Sciences, 2020
The extracellular matrix (ECM) is a highly complex macromolecular network present in all tissues and organs. The ECM is continuously remodelling under an orchestrated process facilitated by many matrix-degrading and matrix-synthesising enzymes in both ...
Nadia Chaher, Reza Hajhosseiny, Alkystis Phinikaridou, René M. Botnar   +3 more
doaj   +1 more source

Extracellular matrix dynamics: tracking in biological systems and their implications

Journal of Biological Engineering, 2022
The extracellular matrix (ECM) constitutes the main acellular microenvironment of cells in almost all tissues and organs. The ECM not only provides mechanical support, but also mediates numerous biochemical interactions to guide cell survival ...
Michael Hu, Zihan Ling, Xi Ren
doaj   +1 more source

Escherichia coli Biofilms Have an Organized and Complex Extracellular Matrix Structure

mBio, 2013
Bacterial biofilms are ubiquitous in nature, and their resilience is derived in part from a complex extracellular matrix that can be tailored to meet environmental demands.
Chia Hung, Yizhou Zhou, Jerome S. Pinkner, Karen W. Dodson, Jan R. Crowley, John Heuser, Matthew R. Chapman, Maria Hadjifrangiskou, Jeffrey P. Henderson, Scott J. Hultgren   +9 more
doaj   +1 more source

Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth

Open Biology, 2022
The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra- and extracellular space, the plasticity of the ECM can be pathological in ...
Carolyn G. Chen, Renato V. Iozzo
doaj   +1 more source

Bursting Dynamics of Spiking Neural Network Induced by Active Extracellular Medium

Mathematics, 2023
We propose a mathematical model of a spiking neural network (SNN) that interacts with an active extracellular field formed by the brain extracellular matrix (ECM). The SNN exhibits irregular spiking dynamics induced by a constant noise drive.
Sergey V. Stasenko, Victor B. Kazantsev
doaj   +1 more source

Using extracellular matrix derived from sugen-chronic hypoxia lung tissue to study pulmonary arterial hypertension

Frontiers in Pharmacology, 2023
Pulmonary arterial hypertension has characteristic changes to the mechanical environment, extracellular matrix, and cellular proliferation. In order to develop a culture system to investigate extracellular matrix (ECM) compositional-dependent changes in ...
Patrick A. Link, Laszlo Farkas, Rebecca L. Heise   +2 more
doaj   +1 more source

Extracellular Matrix (ECM) Activates β-catenin Signaling in Uterine Fibroids [PDF]

Reproduction, 2018
κΩΨ¥–€™±≈‰ greater than > less than Recent studies showed that genetic aberrations in the MED12 gene, probably through the canonical WNT/β-catenin pathway, lead to the pathogenesis of uterine fibroids. However, a comprehensive analysis of the WNT pathway in MED12-mutated and MED12-wild type fibroids has not been performed.
Ko, Y., Jamaluddin, M., Adebayo, M., Bajwa, P., Scott, R., Dharmarajan, Arunasalam, Nahar, P., Tanwar, P.   +7 more
openaire   +3 more sources

Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia

Leukemia Research Reports, 2018
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been ...
Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi   +6 more
doaj   +1 more source

Prediction of Extracellular Matrix Proteins by Fusing Multiple Feature Information, Elastic Net, and Random Forest Algorithm

Mathematics, 2020
Extracellular matrix (ECM) proteins play an important role in a series of biological processes of cells. The study of ECM proteins is helpful to further comprehend their biological functions.
Minghui Wang, Lingling Yue, Xiaowen Cui, Cheng Chen, Hongyan Zhou, Qin Ma, Bin Yu   +6 more
doaj   +1 more source