Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis
Frontiers in Genetics, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix ...
Shuji Mizumoto, Shuhei Yamada
doaj +1 more source
Toward a Designable Extracellular Matrix: Molecular Dynamics Simulations of an Engineered Laminin-mimetic, Elastin-like Fusion Protein [PDF]
Biomacromolecules, 2016, 2016 Native extracellular matrices (ECMs), such as those of the human brain and other neural tissues, exhibit networks of molecular interactions between specific matrix proteins and other tissue components. Guided by these naturally self-assembling supramolecular systems, we have designed a matrix-derived protein chimera that contains a laminin globular ...
arxiv +1 more source
Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation [PDF]
, 2012 Throughout pregnancy the cytotrophoblast, the stem cell of the placenta, gives rise to the differentiated forms of trophoblasts. The two main cell lineages are the syncytiotrophoblast and the invading extravillous trophoblast.
Alexander +37 more
core +2 more sources
The basement membrane protein nidogen-1 supports platelet adhesion and activation
Platelets, 2021 The core structure of the extracellular basement membrane is made up of self-assembling networks of collagen and laminin which associate with each other through the bridging adapter proteins including the sulfated monomeric glycoprotein nidogen.
Hari Hara Sudhan Lakshmanan +12 more
doaj +1 more source
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. [PDF]
, 2016 AIMS: Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins has been performed. METHODS AND
David N. Potier +17 more
core +2 more sources
Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain [PDF]
, 1999 Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion.
Aeschlimann, D +5 more
core +1 more source
Extracellular Matrix Proteins and Tumor Angiogenesis [PDF]
, 2010 Tumor development is a complex process that relies on interaction and communication between a number of cellular compartments. Much of the mass of a solid tumor is comprised of the stroma which is richly invested with extracellular matrix.
Campbell, N. E. +5 more
core +3 more sources
Stepwise Evolution of Coral Biomineralization Revealed with Genome-Wide Proteomics and Transcriptomics. [PDF]
PLoS ONE, 2016 Despite the importance of stony corals in many research fields related to global issues, such as marine ecology, climate change, paleoclimatogy, and metazoan evolution, very little is known about the evolutionary origin of coral skeleton formation.
Takeshi Takeuchi +4 more
doaj +1 more source
Thymocyte migration: an affair of multiple cellular interactions?
Brazilian Journal of Medical and Biological Research, 2003 Cell migration is a crucial event in the general process of thymocyte differentiation. The cellular interactions involved in the control of this migration are beginning to be defined.
W. Savino +8 more
doaj +3 more sources
Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity [PDF]
, 2010 The netrin-like (NTR) domain is a feature of several extracellular proteins, most notably the N-terminal domain of tissue inhibitors of metalloproteinases (TIMPs), where it functions as a strong inhibitor of matrix metalloproteinases and some other ...
Bekhouche, M +11 more
core +3 more sources