Results 51 to 60 of about 866,232 (334)

Label-free optical monitoring of surface adhesion of extracellular vesicles by grating coupled interferometry [PDF]

, 2013
In this proof-of-principle study a label-free optical sensor is demonstrated to monitor the surface adhesion of extracellular vesicles secreted by live cells on to various extracellular matrix ...
A. Kittel, A. Nemeth, B. Gyorgy, Clayton, D. Patko, de Vrij, E.I. Buzas, Estevez, Gyorgy, Gyorgy, Horvath, Horvath, Horvath, Huber, Hunt, Janowska-Wieczorek, K.E. Szabó-Taylor, Koumangoye, Kozma, Kozma, Leroyer, Lukosz, Patko, R. Horvath, Tesselaar, Théry, Valadi, van der Pol, van der Zee, Yuana   +29 more
core   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

CCN Family: Matricellular Proteins in Cartilage and Bone Development [PDF]

, 2016
The extracellular matrix is the intricate scaffolding which surrounds and supports cells and helps to organize them into tissues and organs. The CCN family of matricellular proteins helps to regulate and modulate production, degradation, and remodeling ...
Arnott, John A., Doane, Kathleen, Planey, Sonia Lobo   +2 more
core   +2 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source

Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]

PLoS ONE, 2017
Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck, Anthony W Herren, Sergey Yechikov, Hillary K J Kao, Ambereen Khan, Brett S Phinney, Nipavan Chiamvimonvat, James W Chan, Deborah K Lieu   +8 more
doaj   +1 more source

A Bioinformatics Study for Recognition of Hub Genes and Pathways in Pancreatic Ductal Adenocarcinoma [PDF]

arXiv, 2023
Background: The aim of this study is to use bioinformatics to discover the biomarkers associated with patients with Pancreatic Ductal Adenocarcinoma(PDAC). Material and Methods: GSE28735, GSE15471, and GSE62452 are gene microarray datasets drived from the GEO database, included 153 PDAC samples and 145 normal samples. By analyzing both Gene Ontology (
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and small Rho-family GTPases [PDF]

, 2017
Collective cell migration is a hallmark of developmental and patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets can be influenced by extracellular cues, including cell-cell and cell-matrix interactions.
arxiv   +1 more source

FAM20C Functions Intracellularly Within Both Ameloblasts and Odontoblasts In Vivo [PDF]

, 2013
FAM20C, also known as Golgi casein kinase (G‐CK), is proposed to be the archetype for a family of secreted kinases that phosphorylate target proteins in the Golgi and in extracellular matrices, but FAM20C serving an extracellular function is ...
Al-Hashimi, Brunati, Chan, Delgado, Duncan, Feng, Fincham, Ishikawa, Kawasaki, Nadanaka, Nalbant, O'Sullivan, Ryu, Simmer, Simpson, Tagliabracci, Tagliabracci, Wang, Wang, Yamakoshi   +19 more
core   +1 more source