Results 51 to 60 of about 659,606 (256)

Palmitate-Induced Cell Death and Mitochondrial Respiratory Dysfunction in Myoblasts are Not Prevented by Mitochondria-Targeted Antioxidants

Cellular Physiology and Biochemistry, 2014
Background/Aims: Deleterious effects of saturated fatty acids in skeletal muscle cells are well known but their impact on mitochondrial respiration has not been well studied.
Jana Patková, Michal Anděl, Jan Trnka
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor Improves Leukocyte Energy Metabolism in Hereditary Hemorrhagic Telangiectasia

Life, 2023
The interplay between hypoxia-inducible factors (HIFs) and transforming growth factor beta (TGF-β) is critical for both inflammation and angiogenesis. In hereditary hemorrhagic telangiectasia (HHT), we have previously observed that impairment of the TGF ...
Yves Schild, Jonah Bosserhoff, Freya Droege, Elisabeth Littwitz-Salomon, Joachim Fandrey, Anna Wrobeln   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Microencapsulation technology by nature: Cell derived extracellular vesicles with therapeutic potential [PDF]

, 2013
Cell derived extracellular vesicles are submicron structures surrounded by phospholipid bilayer and released by both prokaryotic and eukaryotic cells.
E. Buzás, A. Falus, Á. Kittel, Buzás, E., Kittel, Ágnes, Falus, A.   +5 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Respiration in the mesopelagic and bathypelagic zones of the oceans [PDF]

, 2005
This chapter reviews the mechanisms of transport and remineralization of organic matter in the dark water-columns and sediments of the oceans. Different approaches to estimating respiration rates are compared, and the discrepancies obtained by different ...
Middelburg, J.J., Susana Agustí, Duarte, C.M., Javier Arístegui, Carlos M. Duarte, Agustí, S., Arístegui, Javier, Arístegui, J., Jack J. Middelburg, Agustí, Susana, Duarte, Carlos M., Middelburg, Jack J.   +11 more
core   +2 more sources

A novel extracellular flux assay workflow uncovers impaired sciatic nerve mitochondrial respiration in diabetic db/db mice

Cell Communication and Signaling
Abnormal mitochondrial function contributes to the development of diabetic neuropathy by inducing oxidative stress and altering energy metabolism, ultimately leading to neuronal damage.
Sebastian Sill, D. Margriet Ouwens, Fariba Zivehe, Sonja Hartwig, Stefan Lehr, Gidon J. Bönhof, Michael Roden, Hadi Al-Hasani, Alexandra Chadt, Alexander Strom   +9 more
doaj   +1 more source

Characteristics of stem respiration in black spruce (Picea mariana) stand, interior Alaska

, 2021
Boreal forests account for roughly one third of the carbon sequestered in terrestrial ecosystems, and the high-latitude boreal ecosystem they make up has been consequently vulnerable to recent climate change.
Suzuki, Rikie, Kim, Seong-Deog, Rikie Suzuki, Bang-Yong Lee, Seong-Deog Kim, Lee, Bang-Yong, Kim, Yongwon, Yongwon Kim   +7 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source