Results 61 to 70 of about 169,199 (298)

Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor Improves Leukocyte Energy Metabolism in Hereditary Hemorrhagic Telangiectasia

Life, 2023
The interplay between hypoxia-inducible factors (HIFs) and transforming growth factor beta (TGF-β) is critical for both inflammation and angiogenesis. In hereditary hemorrhagic telangiectasia (HHT), we have previously observed that impairment of the TGF ...
Yves Schild, Jonah Bosserhoff, Freya Droege, Elisabeth Littwitz-Salomon, Joachim Fandrey, Anna Wrobeln   +5 more
doaj   +1 more source

Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH [PDF]

, 2020
Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this ...
Berkmann, Julia C., Duda, Georg N., Ellinghaus, Agnes, Lippens, Evi, Martin, Aaron X. Herrera, Schell, Hanna, Schlundt, Claudia, Schmidt-Bleek, Katharina, Tsitsilonis, Serafeim   +8 more
core   +2 more sources

Geobacter sulfurreducens Extracellular Multiheme Cytochrome PgcA Facilitates Respiration to Fe(III) Oxides But Not Electrodes [PDF]

Frontiers in Microbiology, 2017
Abstract Extracellular cytochromes are hypothesized to facilitate the final steps of electron transfer between the outer membrane of the metal-reducing bacterium Geobacter sulfurreducens and solid-phase electron acceptors such as metal oxides and electrode surfaces during the course
Lori A. Zacharoff, Dana J. Morrone, Daniel R. Bond, Daniel R. Bond   +3 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A functional description of CymA, an electron-transfer hub supporting anaerobic respiratory flexibility in Shewanella [PDF]

, 2012
CymA (tetrahaem cytochrome c) is a member of the NapC/NirT family of quinol dehydrogenases. Essential for the anaerobic respiratory flexibility of shewanellae, CymA transfers electrons from menaquinol to various dedicated systems for the reduction of ...
Butt, Julea N., Bye, Jordan, Cheesman, Myles R., Fredrickson, Jim, Jeuken, Lars J. C., Lowe, Thomas G., Marritt, Sophie J., McMillan, Duncan G. G., Richardson, David J., Shi, Liang, Zachara, John   +10 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Isolation and Electrochemical Analysis of a Facultative Anaerobic Electrogenic Strain Klebsiella sp. SQ-1

Polish Journal of Microbiology
Electricigens decompose organic matter and convert stored chemical energy into electrical energy through extracellular electron transfer. They are significant biocatalysts for microbial fuel cells with practical applications in green energy generation ...
Zhou Lei, Tang Tuoxian, Deng Dandan, Wang Yayue, Pei Dongli   +4 more
doaj   +1 more source

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Bonney, Megan, Borchers, Christoph H., Brodsky, Kelley, Eckle, Tobias, Eltzschig, Holger K., Han, Jun, Kominsky, Douglas J., Mariani, Thomas J., Mittelbronn, Michel Guy André, Packard, Thomas   +9 more
core   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Small extracellular vesicles from senescent stem cells trigger adaptive mechanisms in young stem cells by increasing antioxidant enzyme expression

Redox Biology, 2023
Extracellular vesicles' biogenesis, shedding, and uptake are redox-sensitive. Indeed, oxidative stress conditions influence extracellular vesicles’ release and content, which can modulate the redox status of the receiving cells.
Cristina Mas-Bargues, Jorge Sanz-Ros, Nekane Romero-García, Javier Huete-Acevedo, Mar Dromant, Consuelo Borrás   +5 more
doaj   +1 more source