Results 191 to 200 of about 53,988 (240)

A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas. [PDF]

Proc Natl Acad Sci U S A
Chan M, Zhu S, Russell ZR, Arora S, Arakaki AKS, Vaz JM, Kumasaka D, Szulzewsky F, Michealraj A, Holland EC, Gujral TS.   +10 more
europepmc   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

ROS: their roles in diminished ovarian reserve. [PDF]

Front Endocrinol (Lausanne)
Chen X, Liu D.
europepmc   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Distinct Interferon and Intracellular Signaling Signatures in Systemic Lupus Erythematosus and Dermatomyositis by Integrative Transcriptomic and Proteomic Analysis. [PDF]

ACR Open Rheumatol
Ward JM, Ambatipudi M, Manna Z, Schiffenbauer A, Smith MA, Rahman S, Miller FW, Kaplan MJ, Li JL, Casey KA, Hasni S, Rider LG.   +11 more
europepmc   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Signaling pathways in systemic lupus erythematosus and therapeutic implications. [PDF]

Front Immunol
Balogh L, Kovács VG, Nagy G, Németh T.
europepmc   +1 more source

mTORC1 and nuclear ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation. [PDF]

Sci Signal
Uchida K, Scarborough EA, Pruzinsky E, Stone KR, Hartman H, Kelly DP, Edwards JJ, Kehat I, Prosser BL.   +8 more
europepmc   +1 more source

Coagulation protease-activated receptor-2 (PAR2) promotes dyslipidemia, obesity and MASLD through repression of the hepatic pioneer factor HNF4α. [PDF]

JHEP Rep
Chen X, Nguyen N, Turner SE, Tai AK, Abdelmalek MF, Covic L, Kuliopulos A.   +6 more
europepmc   +1 more source