The role of phosphatidylinositide‐3‐kinase in basal mitogen‐activated protein kinase activity and cell survival [PDF]
FEBS Letters, 1999 Phosphatidylinositide‐3‐OH‐kinase (PI 3‐kinase) is an upstream activator of p42/p44 mitogen‐activated protein kinase (MAPK), but the role of PI 3‐kinase‐dependent MAPK remains obscure. Here we demonstrate that in a variety of different cell types, PI 3‐kinase inhibition results in an inhibition of MAPK in unstimulated cells but does not interfere with ...
Henri H. Versteeg +3 more
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Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3 [PDF]
Journal of Biological Chemistry, 1995 GATA-2 is a member of a family of transcription factors which bind a common DNA sequence motif (WGA-TAR) through an evolutionarily conserved zinc finger domain. An essential role for GATA-2 in the development of hematopoietic stem cells has recently been shown in gene targeting experiments in mice.
Masayuki Towatari +6 more
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Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function [PDF]
Journal of Biological Chemistry, 2010 Mitogen-activated protein kinase kinase 3 (MAP2K3) is a member of the dual specificity kinase group. Growing evidence links MAP2K3 to invasion and tumor progression. Here, we identify MAP2K3 as a transcriptional target of endogenous gain-of-function p53 mutants R273H, R175H, and R280K.
Aymone Gurtner +5 more
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Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication [PDF]
International Journal of Molecular Sciences, 2021 Zinc chloride is known to be effective in combatting hepatitis A virus (HAV) infection, and zinc ions seem to be especially involved in Toll-like receptor (TLR) signaling pathways. In the present study, we examined this involvement in human hepatoma cell lines using a human TLR signaling target RT-PCR array.
Tatsuo Kanda +5 more
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Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 [PDF]
Journal of Biological Chemistry, 2017 The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α.
Bassi, Rekha +7 more
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Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) [PDF]
Cardiovascular Research, 2007 Our aim was to examine the role of mitogen-activated protein kinase kinase 3 (MKK3) in the development of left ventricular (LV) remodeling following myocardial infarction (MI).MKK3-null mice were subjected to permanent coronary artery ligation. Twenty-eight days after MI, haemodynamics in male mkk3+/+(WT) and mkk3-/-(KO) littermates were assessed using
Clark, J +5 more
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MAPK3 (mitogen-activated protein kinase 3) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on MAPK3 (mitogen-activated protein kinase 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Tuncay, S, Banerjee, S
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The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes [PDF]
, 2014 Peer reviewedPublisher ...
Berry, Susan +8 more
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Mitogen-Activated Protein Kinase Kinase 3 Regulates Seed Dormancy in Barley [PDF]
Current Biology, 2016 Seed dormancy has fundamental importance in plant survival and crop production; however, the mechanisms regulating dormancy remain unclear [1-3]. Seed dormancy levels generally decrease during domestication to ensure that crops successfully germinate in the field.
Nakamura, S +16 more
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The many-faced KSR1: a tumor suppressor in breast cancer [PDF]
, 2015 Emerging evidence supports the dual function of kinase suppressor of Ras 1 (KSR1) as an active kinase and a scaffold, although it has been extensively referred as a pseudokinase, due to the absence of key residues in its catalytic domain [1, 2].
Giamas, Georgios +2 more
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