Mitogen-Activated Protein Kinase 3 [PDF]
Definitions, 2020 Mitogen-activated protein kinase 3 (379 aa, ~43 kDa) is encoded by the human MAPK3 gene. This protein plays a role in transcriptional regulation, serine/threonine phosphorylation and both cytokine-dependent and stress-activated signaling.
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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 [PDF]
Definitions, 2020 Mitogen-activated protein kinase kinase kinase kinase 3 (894 aa, kDa) encoded by the human MAP4K3 gene. protein plays Jun signaling pathway.
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Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 [PDF]
Journal of Biological Chemistry, 2017 The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-
R. Bassi +7 more
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Evidence for a Role of Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase in the Development of Testicular Ischemia-Reperfusion Injury [PDF]
Biology of Reproduction, 2005 Mitogen-activated protein kinase (MAPK) 3/MAPK1 (also known as ERK1/ERK2) plays an important role in the signal transduction pathways. To our knowledge, however, its role in the development of testicular ischemia-reperfusion injury has not yet been investigated.
L. Minutoli +11 more
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Mitogen-Activated Protein Kinase Kinase 3 Regulates Seed Dormancy in Barley. [PDF]
Current Biology, 2016 Seed dormancy has fundamental importance in plant survival and crop production; however, the mechanisms regulating dormancy remain unclear [1-3]. Seed dormancy levels generally decrease during domestication to ensure that crops successfully germinate in the field.
S. Nakamura +16 more
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Modulation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 by Hepatitis C Virus Core Protein [PDF]
Journal of Virology, 2013 ABSTRACT Hepatitis C virus (HCV) is highly dependent on cellular proteins for its own propagation. In order to identify the cellular factors involved in HCV propagation, we performed protein microarray assays using the HCV core protein as a probe.
H. Ngo +4 more
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MAPK3 (mitogen-activated protein kinase 3) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on MAPK3 (mitogen-activated protein kinase 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Seda Tunçay, Sreeparna Banerjee
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BRCA1 Interacts with and Is Required for Paclitaxel-Induced Activation of Mitogen-Activated Protein Kinase Kinase Kinase 3 [PDF]
Cancer Research, 2004 Abstract BRCA1 has been implicated in a number of cellular processes, including transcriptional regulation, DNA damage repair, cell cycle arrest, and apoptosis. We identified mitogen-activated protein kinase (MAPK) kinase kinase 3 (MEKK3), an upstream regulator of the c-Jun NH2-terminal kinase/stress-activated protein kinase and p38/MAPK
Paula M. Gilmore +12 more
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Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. [PDF]
Proceedings of the National Academy of Sciences, 2006 p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3 −/− mice. These studies showed that TNF-
Tomoyuki Inoue +6 more
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Parallel Regulation of Mitogen-activated Protein Kinase Kinase 3 (MKK3) and MKK6 in Gq-signaling Cascade* [PDF]
Journal of Biological Chemistry, 2001 Heterotrimeric G protein Gq stimulates the activity of p38 mitogen-activated protein kinase (MAPK) in mammalian cells. To investigate the signaling mechanism whereby α and βγ subunits of Gq activate p38 MAPK, we introduced kinase-deficient mutants of ...
J. Yamauchi +3 more
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