Results 41 to 50 of about 369,896 (355)

Regulation of the G2/M Transition in Rodent Oocytes [PDF]

, 2010
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core   +2 more sources

The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis

Frontiers in Plant Science, 2015
In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28 and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induces genes.
G.H.M. eSagor, Pratima eChawla, Dong Wook eKim, Thomas eBerberich, Seiji eKojima, Masaru eNiitsu, Tomonobu eKusano   +6 more
doaj   +1 more source

Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line

Poultry Science, 2020
Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj   +1 more source

Distinct signalling pathways mediate insulin and phorbol ester- stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells [PDF]

, 2000
Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and ...
Alessi, Alessi, Alessi, Beretta, Brostrom, Brunn, Burgering, Burnett, Cheatham, Chung, Cross, Dudley, Dufner, Favata, Flynn, Fukunaga, Gingras, Gingras, Haghighat, Hara, Haystead, Huang, Jefferies, Kitamura, Kleijn, Kohn, Kohn, Lamphear, Lin, Lin, Manzella, Marcotrigiano, Mendez, Monfar, Morley, Morley, Morley, Morris, Mukhopadhyay, Nave, Nissley, Pause, Petritsch, Polakiewicz, Price, Proud, Ptushkina, Pyronnet, Pyronnet, Rao, Rasmussen, Rau, Schonwasser, Scott, Scott, Sonenberg, Stokoe, Terada, Ueki, von Manteuffel, Vries, Wang, Waskiewicz, Waskiewicz   +63 more
core   +1 more source

Caenorhabditis elegans and probiotics interactions from a prolongevity perspective [PDF]

, 2019
Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation.
Barbara Guantario, Chiara Devirgiliis, Daniela Uccelletti, Marianna Roselli, Paola Zinno, SCHIFANO, EMILY   +5 more
core   +1 more source

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]

, 2014
BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Topolewski, Katharyn   +3 more
core   +3 more sources

Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons [PDF]

Journal of Biological Chemistry, 2005
There is accumulating evidence that the p38 MAP kinase pathway plays important roles in Type I interferon (IFN) signaling, but the mechanisms regulating p38 activation during engagement of the Type I IFN receptor remain to be defined. We sought to identify the events that lead to activation of the p38 MAP kinase in response to Type I IFNs.
Yongzhong, Li, Sandeep, Batra, Antonella, Sassano, Beata, Majchrzak, David E, Levy, Matthias, Gaestel, Eleanor N, Fish, Roger J, Davis, Leonidas C, Platanias   +8 more
openaire   +2 more sources

Mitogen‐activated protein kinase/extracellular signal‐regulated kinase attenuates 3‐hydroxykynurenine‐induced neuronal cell death [PDF]

Journal of Neurochemistry, 2004
Abstract3‐Hydroxykynurenine (3‐HK), an endogenous tryptophan metabolite, is known to have toxic effects in brain. However, the molecular mechanism of the toxicity has not been well identified. In this study, we investigated the involvement of MAPK/extracellular signal‐regulated kinase (ERK) in the 3‐HK‐induced neuronal cell damage.
Hyun Jung, Lee, Jae-Hyung, Bach, Hee-Sun, Chae, Sang Hyung, Lee, Wan Seok, Joo, Se Hoon, Choi, Kyung Yong, Kim, Won Bok, Lee, Sung Su, Kim   +8 more
openaire   +2 more sources

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice [PDF]

The EMBO Journal, 1999
The p38 mitogen-activated protein kinase (MAPK) pathway, like the c-Jun N-terminal kinase (JNK) MAPK pathway, is activated in response to cellular stress and inflammation and is involved in many fundamental biological processes. To study the role of the p38 MAPK pathway in vivo, we have used homologous recombination in mice to inactivate the Mkk3 gene,
Lu, Hong-Tao, Yang, Derek D., Wysk, Mark Allen, Gatti, Evelina, Mellman, Ira, Davis, Roger J., Flavell, Richard A.   +6 more
openaire   +3 more sources

Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106. [PDF]

, 2016
A collective body of evidence indicates that estrogen protects the heart from myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism remains incompletely understood. We have previously delineated a novel mechanism of how 17β-estradiol
Kim, Jin Kyung, Liu, Han, Luo, Tao
core   +1 more source