Results 41 to 50 of about 395,145 (302)
Poultry Science, 2020 Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong +5 more
doaj +1 more source
Inhibition of Mitogen-activated Protein Kinase Phosphatase 3 Activity by Interdomain Binding [PDF]
Journal of Biological Chemistry, 2008 Mitogen-activated protein (MAP) kinase phosphatase 3 (MKP3) is a cytoplasmic dual specificity phosphatase that functions to attenuate signaling via dephosphorylation and subsequent deactivation of its substrate and allosteric regulator, extracellular signal-regulated protein kinase 2 (ERK2).
John K, Mark +3 more
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Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3 [PDF]
Journal of Biological Chemistry, 1996 Mitogen-activated protein/ERK kinase kinases (MEKKs) phosphorylate and activate protein kinases which in turn phosphorylate and activate the p42/44 mitogen-activated protein kinase (MAPK), c-Jun/stress-activated protein kinases (JNKs), and p38/Hog1 kinase. We have isolated the cDNAs for two novel mammalian MEKKs (MEKK 2 and 3).
Jonathan L. Blank +4 more
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Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons [PDF]
Journal of Biological Chemistry, 2005 There is accumulating evidence that the p38 MAP kinase pathway plays important roles in Type I interferon (IFN) signaling, but the mechanisms regulating p38 activation during engagement of the Type I IFN receptor remain to be defined. We sought to identify the events that lead to activation of the p38 MAP kinase in response to Type I IFNs.
Yongzhong, Li +8 more
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Journal of Biological Chemistry, 1996 Mammalian heat shock genes are regulated at the transcriptional level by heat shock factor-1 (HSF-1), a sequence-specific transcription factor.
B. Chu +4 more
semanticscholar +1 more source
Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines [PDF]
Journal of Biological Chemistry, 1996 Hemopoietic cells respond to cytokines by initiating tyrosine phosphorylation of receptors and receptor-associated proteins, leading to the activation of numerous cytosolic and membrane associated enzymes, including phosphatidylinositol 3-OH kinase (PI 3-kinase).
M P, Scheid, V, Duronio
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Journal of Pharmacological Sciences, 2006 .: Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK).
Youn Ri Lee +9 more
doaj +1 more source
Ser-3 Is Important for Regulating Mos Interaction with and Stimulation of Mitogen-Activated Protein Kinase Kinase [PDF]
Molecular and Cellular Biology, 1995 Mos is a germ cell-specific serine/threonine protein kinase that activates mitogen-activated protein kinase (MAPK) through MAPK kinase (MKK). In Xenopus oocytes, Mos synthesis is required for progesterone-induced activation of MAPK and maturation promoting factor.
M, Chen, J A, Cooper
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PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression
Molecular & Cellular Oncology, 2017 Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-
Leslie Ann Caromile, Linda H. Shapiro
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Journal of Biological Chemistry, 1995 The role of the p90 ribosomal protein S6 kinase/mitogen-activated protein kinase (RSK/MAPK) signaling pathway in regulating glycogen synthase kinase-3 (GSK-3) activity was investigated.
H. Eldar-Finkelman +3 more
semanticscholar +1 more source