Results 61 to 70 of about 369,896 (355)

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

MAP3K1: A Multifunctional Kinase at the Crossroads of Cancer Progression and Tumor Suppression

Cells
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) possesses dual enzymatic functions, i.e., kinase and E3 ubiquitin ligase activities, orchestrating proliferation, survival, apoptosis, DNA damage response, and immune modulation.
Lelisse T. Umeta, Amarnath Natarajan
doaj   +1 more source

The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K–Akt Pathways

Pharmaceutics, 2022
The targeting of the Mitogen-Activated Protein Kinase (MAPK) signalling pathway in melanoma improves the prognosis of patients harbouring the V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) mutation.
Saverio Candido, Rossella Salemi, Sara Piccinin, Luca Falzone, Massimo Libra   +4 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Global analysis of serine/threonine and tyrosine protein phosphatase catalytic subunit genes in Neurospora crassa reveals interplay between phosphatases and the p38 mitogen-activated protein kinase. [PDF]

, 2013
Protein phosphatases are integral components of the cellular signaling machinery in eukaryotes, regulating diverse aspects of growth and development. The genome of the filamentous fungus and model organism Neurospora crassa encodes catalytic subunits for
Borkovich, Katherine A, Ghosh, Arit, Park, Gyungsoon, Servin, Jacqueline A   +3 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]

, 2010
The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core   +1 more source

3′,5′‐Cyclic Guanosine Monophosphate Activates Mitogen‐Activated Protein Kinase in Rat Pinealocytes [PDF]

Journal of Neurochemistry, 1999
Abstract : The role of 3′,5′‐cyclic guanosine monophosphate (cGMP) in the activation of mitogen‐activated protein kinases (MAPKs) was investigated in rat pinealocytes. Treatment with dibutyryl cGMP (DBcGMP) dosedependently increased the phosphorylation of both p44 and p42 isoforms of MAPK.
A K, Ho, K, Hashimoto, C L, Chik
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast [PDF]

, 2012
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 ...
A Ali, A Mitchell, A Plaine, A Roetzer, A Roetzer, A Walther, A Winkler, AA Duina, AE Piispanen, Alex Andrianopoulos, Alistair J. P. Brown, AP Gasch, B Eisman, B Enjalbert, B Enjalbert, B Enjalbert, BK Jakobsen, C Csank, C Giardina, C Queitsch, C San Jose, CA Munro, Carol Munro, CH de Dios, CJ Nobile, D Chen, DA Davis, DA Smith, DF Jarosz, DF Jarosz, DF Smith, DM Arana, DR Wysong, E Kussell, E Leberer, E Nikolaou, E Roman, EA Craig, EA Elion, ET Burt, F Estruch, F Lamoth, F Navarro-Garcia, F Navarro-Garcia, F Navarro-García, F Sherman, FA Guhad, G Degols, G Wiederrecht, G Wiederrecht, GJ Gallo, H Garreau, H Lavoie, HC Causton, I Tirosh, IV Ene, J Chen, J Zou, JL Brewster, JR Blankenship, K-H Chen, LA Walker, LA Walker, LE Cowen, Leah E. Cowen, Louise Walker, M Ramsdale, M Taipale, MD Leach, MD Leach, MD Leach, MD Leach, ME Feder, Michelle D. Leach, MM Bradford, N Shulga, P Gónzalez-Párraga, P Hawle, PD Cantero, PK Sorger, PK Sorger, R Alonso-Monge, R Alonso-Monge, R Diez-Orejas, RA Monge, RB Wilson, RS Hegde, RS Shapiro, S Bates, S Diezmann, S Kuge, S Nicholls, S Nicholls, S Nicholls, SD Singh, SH Millson, SK Prill, SL LaFayette, SL Rutherford, SM Noble, SM O'Rourke, SM Roe, Susan Budge, TT Wimalasena, VM Bruno, VM Bruno, WA Fonzi, WM Toone, X Zhang, Y Guo, Y Kamada   +110 more
core   +3 more sources