Results 51 to 60 of about 395,145 (302)

Epidermal Growth Factor Induces Vasoconstriction Through the Phosphatidylinositol 3-Kinase-Mediated Mitogen-Activated Protein Kinase Pathway in Hypertensive Rats

Journal of Pharmacological Sciences, 2006
.: We investigated whether increased contractile responsiveness to epidermal growth factor (EGF) is associated with altered activation of mitogen-activated protein kinase (MAPK) in the aortic smooth muscle of deoxycorticosterone acetate (DOCA)-salt ...
Kim Junghwan, Lee Chang-Kwon, Park Hyo-Jun, Kim Hyo Jin, So Hyun Ha, Lee Keun Sang, Lee Hwan Myung, Roh Hui Yul, Choi Wahn Soo, Park Tae Kyu, Kim Bokyung   +10 more
doaj   +1 more source

Research on the Mechanism of HRP Relieving IPEC-J2 Cells Immunological Stress Based on Transcriptome Sequencing Analysis

Frontiers in Nutrition, 2022
Early weaning increased the economic benefits of piglets. However, early weaning damages the intestinal barrier of piglets and causes immunological stress.
Muyang Li, Lu Chen, Yiran Zhao, Hui Sun, Lei Zhao   +4 more
doaj   +1 more source

MAP3K1: A Multifunctional Kinase at the Crossroads of Cancer Progression and Tumor Suppression

Cells
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) possesses dual enzymatic functions, i.e., kinase and E3 ubiquitin ligase activities, orchestrating proliferation, survival, apoptosis, DNA damage response, and immune modulation.
Lelisse T. Umeta, Amarnath Natarajan
doaj   +1 more source

MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3

BMC Cancer, 2013
microRNA 21 (miR-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (HCC). In the present study, we investigated the role of miR-21 in HCC by identifying its novel targets, as well as ...
Guangxian Xu, Yi-lin Zhang, Jun Wei, Wei Jia, Zhaohui Ge, Zhaobo Zhang, Xiaoming Liu   +6 more
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Evaluation of 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one as a p38 MAPK inhibitor in MCF-7 and MDA-MB-231 breast cancer cell lines

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Breast cancer is a diverse disease with high mortality rates, often due to metastasis. Breast cancer subtypes vary by the expression of progesterone receptor, human epidermal growth factor receptor 2, and estrogen receptor.
Mustafa Abdul Jabbar a Qader, Intesar Tarik Numan, Basma Talib Al-Sudani, Mohammed A.Abdalqader   +3 more
doaj   +1 more source

The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K–Akt Pathways

Pharmaceutics, 2022
The targeting of the Mitogen-Activated Protein Kinase (MAPK) signalling pathway in melanoma improves the prognosis of patients harbouring the V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) mutation.
Saverio Candido, Rossella Salemi, Sara Piccinin, Luca Falzone, Massimo Libra   +4 more
doaj   +1 more source

The role of phosphatidylinositide‐3‐kinase in basal mitogen‐activated protein kinase activity and cell survival

FEBS Letters, 1999
Phosphatidylinositide‐3‐OH‐kinase (PI 3‐kinase) is an upstream activator of p42/p44 mitogen‐activated protein kinase (MAPK), but the role of PI 3‐kinase‐dependent MAPK remains obscure. Here we demonstrate that in a variety of different cell types, PI 3‐kinase inhibition results in an inhibition of MAPK in unstimulated cells but does not interfere with ...
Versteeg, H. H., Evertzen, M. W., van Deventer, S. J., Peppelenbosch, M. P.   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source