Results 31 to 40 of about 395,145 (302)

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, 2021
Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan, Jing Wang, Jin-feng Xu, Fei Tang, Lu Chen, Yu-zhu Tan, Chao-long Rao, Hui Ao, Cheng Peng   +8 more
doaj   +1 more source

VIP1 response elements mediate mitogen-activated protein kinase 3-induced stress gene expression

Proceedings of the National Academy of Sciences of the United States of America, 2009
The plant pathogen Agrobacterium tumefaciens transforms plant cells by delivering its T-DNA into the plant cell nucleus where it integrates into the plant genome and causes tumor formation.
A. Pitzschke, Armin Djamei, Markus Teige, H. Hirt   +3 more
semanticscholar   +1 more source

Expression and Activation of Mitogen-Activated Protein Kinase Kinases-3 and -6 in Rheumatoid Arthritis [PDF]

The American Journal of Pathology, 2004
The p38 mitogen-activated protein (MAP) kinase signal transduction pathway regulates the production of interleukin-1 and tumor necrosis factor-alpha. p38 kinase inhibitors are effective in animal models of arthritis and are currently being developed in rheumatoid arthritis (RA).
Martine, Chabaud-Riou, Gary S, Firestein
openaire   +2 more sources

Control of host cell phosphorylation by Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2011
Phosphorylation is one of the most frequent modifications in intracellular signaling and is implicated in many processes ranging from transcriptional control to signal transduction in innate immunity.
Eva eHaenssler, Eva eHaenssler, Ralph R. Isberg, Ralph R. Isberg   +3 more
doaj   +1 more source

Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells

Journal of Pharmacological Sciences, 2009
.: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations ...
Sung Lyea Park, You-Mie Kim, Jin-Hee Ahn, Soo Hwan Lee, Eun Joo Baik, Chang-Hyun Moon, Yi-Sook Jung   +6 more
doaj   +1 more source

Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3 [PDF]

Journal of Biological Chemistry, 1995
GATA-2 is a member of a family of transcription factors which bind a common DNA sequence motif (WGA-TAR) through an evolutionarily conserved zinc finger domain. An essential role for GATA-2 in the development of hematopoietic stem cells has recently been shown in gene targeting experiments in mice.
Towatari, M, May, G, Marais, R, Perkins, G, Marshall, C, Cowley, S, Enver, T   +6 more
openaire   +3 more sources

Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools

Frontiers in Pharmacology, 2022
Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects
Yong Jiang, Yi-Zi Xie, Yi-Zi Xie, Chen-Wen Peng, Chen-Wen Peng, Kai-Nan Yao, Xue-Ying Lin, Xue-Ying Lin, Shao-Feng Zhan, Hong-Fa Zhuang, Hui-Ting Huang, Xiao-Hong Liu, Xiu-Fang Huang, Xiu-Fang Huang, Hang Li   +14 more
doaj   +1 more source

Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats

Anais da Academia Brasileira de Ciências, 2015
The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and ...
CRISTIANA S.B. SALVATIERRA, SÍLVIA R.L. REIS, ANA F.M. PESSOA, LETÍCIA M.I. DE SOUZA, LUIZ F. STOPPIGLIA, ROBERTO V. VELOSO, MARISE A.B. REIS, EVERARDO M. CARNEIRO, ANTONIO C. BOSCHERO, EDSON M. COLODEL, VANESSA C. ARANTES, MÁRCIA Q. LATORRACA   +11 more
doaj   +1 more source

OncoPPi-informed discovery of Mitogen-Activated Protein Kinase Kinase 3 as a novel binding partner of c-Myc

Oncogene, 2017
Mitogen-activated protein kinase kinase 3 (MKK3) is a dual threonine/tyrosine protein kinase that regulates inflammation, proliferation and apoptosis through specific phosphorylation and activation of the p38 mitogen-activated protein kinase.
A. Ivanov, Valentina Gonzalez-Pecchi, Layla F. Khuri, Qiankun Niu, Yifeng Wang, Yiran Xu, Yan Bai, Xiulei Mo, E. Prochownik, Margaret A. Johns, Yuhong Du, F. Khuri, H. Fu   +12 more
semanticscholar   +1 more source

The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis

Frontiers in Plant Science, 2015
In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28 and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induces genes.
G.H.M. eSagor, Pratima eChawla, Dong Wook eKim, Thomas eBerberich, Seiji eKojima, Masaru eNiitsu, Tomonobu eKusano   +6 more
doaj   +1 more source