Results 21 to 30 of about 395,145 (302)
Frontiers in Physiology, 2021 Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li +8 more
doaj +1 more source
Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma
Cell Death and Disease, 2022 Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng +10 more
doaj +1 more source
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) [PDF]
Cardiovascular Research, 2007 Our aim was to examine the role of mitogen-activated protein kinase kinase 3 (MKK3) in the development of left ventricular (LV) remodeling following myocardial infarction (MI).MKK3-null mice were subjected to permanent coronary artery ligation. Twenty-eight days after MI, haemodynamics in male mkk3+/+(WT) and mkk3-/-(KO) littermates were assessed using
Clark, J +5 more
openaire +4 more sources
FEBS Open Bio, 2020 Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
doaj +1 more source
Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model
European Journal of Histochemistry, 2022 Cisplatin (CDDP) has been widely used in cancer therapy, but it has been linked to side effects such as nephrotoxicity. Crocin is a carotenoid found in crocus and gardenia flowers that has been shown to have anti-oxidant properties, inhibit tumor growth,
Qichao Yin, Hua Xiong
doaj +1 more source
In Pursuit: A Mother’s Account of Her Son’s Rare Disease Diagnosis Journey
Journal of Patient-Centered Research and Reviews, 2021 A personal account from a mother’s perspective on her undiagnosed son’s medical journey over almost 6 years toward a diagnosis of a rare genetic variant in mitogen-activated protein kinase 8 interacting protein 3 (MAPK8IP3) resulting in neurodevelopment ...
Anne M. Jones
doaj +1 more source
Reproductive Biology and Endocrinology, 2015 BackgroundRecent results indicate a key role for cyclic guanosine monophosphate (cGMP) in the regulation of oocyte meiotic arrest in preovulatory mammalian follicles.
Milan Blaha, L. Němcová, R. Procházka
semanticscholar +1 more source
Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]
F1000Research, 2022 The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy +5 more
doaj +1 more source
Journal of Biological Chemistry, 1996 CSBP p38 is a mitogen-activated protein kinase that is activated in response to stress, endotoxin, interleukin 1, and tumor necrosis factor. Using a catalytically inactive mutant (D168A) of human CSBP2 as the bait in a yeast two-hybrid screen, we have ...
M. McLaughlin +6 more
semanticscholar +1 more source
Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2 [PDF]
Journal of Biological Chemistry, 1999 The mitogen-activated protein kinase phosphatase 3 (MKP3)-catalyzed hydrolysis of aryl phosphates in the absence and presence of extracellular signal-regulated kinase 2 (ERK2) was investigated in order to provide insights into the molecular basis of the ERK2-induced MKP3 activation.
B, Zhou, Z Y, Zhang
openaire +2 more sources