Results 21 to 30 of about 369,896 (355)

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

Cell Death and Disease, 2022
Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu   +10 more
doaj   +1 more source

In Pursuit: A Mother’s Account of Her Son’s Rare Disease Diagnosis Journey

Journal of Patient-Centered Research and Reviews, 2021
A personal account from a mother’s perspective on her undiagnosed son’s medical journey over almost 6 years toward a diagnosis of a rare genetic variant in mitogen-activated protein kinase 8 interacting protein 3 (MAPK8IP3) resulting in neurodevelopment ...
Anne M. Jones
doaj   +1 more source

Evidence for a Role of Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase in the Development of Testicular Ischemia-Reperfusion Injury [PDF]

Biology of Reproduction, 2005
Mitogen-activated protein kinase (MAPK) 3/MAPK1 (also known as ERK1/ERK2) plays an important role in the signal transduction pathways. To our knowledge, however, its role in the development of testicular ischemia-reperfusion injury has not yet been investigated.
MINUTOLI, Letteria, ANTONUCCIO, Pietro, ROMEO, Carmelo, NICOTINA, Piero Antonio, BITTO, ALESSANDRA, ARENA, SALVATORE, POLITO, FRANCESCA, ALTAVILLA, Domenica, TURIACO N, CUTRUPI A, ZUCCARELLO, Biagio, SQUADRITO, Francesco   +11 more
openaire   +3 more sources

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3 [PDF]

Journal of Biological Chemistry, 1996
Mitogen-activated protein/ERK kinase kinases (MEKKs) phosphorylate and activate protein kinases which in turn phosphorylate and activate the p42/44 mitogen-activated protein kinase (MAPK), c-Jun/stress-activated protein kinases (JNKs), and p38/Hog1 kinase. We have isolated the cDNAs for two novel mammalian MEKKs (MEKK 2 and 3).
Jonathan L. Blank, Pär Gerwins, Elicia M. Elliott, Susan Sather, Gary L. Johnson   +4 more
openaire   +2 more sources

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation [PDF]

, 2019
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited
Agostinelli, Enzo, Antonucci, Laura, Bordone, Rosa, Caimano, Miriam, Canettieri, Gianluca, Capalbo, Carlo, Checquolo, Saula, Coni, Sonia, D'Amico, Davide, De Smaele, Enrico, Di Magno, Laura, Di Marcotullio, Lucia, Di Pastena, Fiorella, Giorgi, Alessandra, Manni, Simona, Maroder, Marella, Petroni, Marialaura, Schininà, Maria Eugenia, Serrao, Silvia Maria, Yates Iii, John R, Yurtsever, Zuleyha Nihan   +20 more
core   +1 more source

Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]

F1000Research, 2022
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy, Shahab Uddin, Abdullah Azmi, Ajaz Bhat, Lubna Therachiyil, Anjana Anand   +5 more
doaj   +1 more source

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen [PDF]

, 2017
The authors thank E. Veal for intellectual input. This work was funded by the UK Biotechnology and Biological Research Council [J.Q. BB/K016393/1; A.J.P.B.
Brown, Alistair J P, Day, Alison M, Herrero-de-Dios, Carmen M., MacCallum, Donna M, Quinn, Janet   +4 more
core   +2 more sources

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, 2021
Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan, Jing Wang, Jin-feng Xu, Fei Tang, Lu Chen, Yu-zhu Tan, Chao-long Rao, Hui Ao, Cheng Peng   +8 more
doaj   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C., Bibby, Bo Martin, Funding, Anne, Iversen, Lars, Johansen, Claus, Kragballe, Knud, Lilleholt, Louise Langer   +6 more
core   +3 more sources

Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2 [PDF]

Journal of Biological Chemistry, 1999
The mitogen-activated protein kinase phosphatase 3 (MKP3)-catalyzed hydrolysis of aryl phosphates in the absence and presence of extracellular signal-regulated kinase 2 (ERK2) was investigated in order to provide insights into the molecular basis of the ERK2-induced MKP3 activation.
B, Zhou, Z Y, Zhang
openaire   +2 more sources