Results 1 to 10 of about 234,809 (168)
Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics. [PDF]
PLoS ONEMitogen-activated protein kinase 1 (MAPK1) is a serine/threonine kinase that plays a crucial role in the MAP kinase signaling transduction pathway.
Md Nayab Sulaimani +6 more
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CellsMitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) is a key signaling molecule essential for eyelid closure during embryogenesis. In mice, Map3k1 knockout leads to a fully penetrant eye-open at birth (EOB) phenotype due to disrupted MAPK signaling,
Maureen Mongan +4 more
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Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood
Acta Dermato-Venereologica, 2022 Pyogenic granuloma is one of the most common vascular tumours. The cause of pyogenic granuloma was previously thought to be an inflammatory reaction with consecutive stimulation of endothelial cell proliferation.
Katharina Strobel +6 more
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Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]
PLoS ONE, 2008 Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay +9 more
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Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]
PLoS ONE, 2013 Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and bioavailability. Malvidin
Eszter Bognar +7 more
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Olea europaea Suppresses Inflammation by Targeting TAK1-Mediated MAP Kinase Activation
Molecules, 2021 Possessing a variety of medicinal functions, Olea europaea L. is widely cultivated across the world. However, the anti-inflammatory mechanism of Olea europaea is not yet fully elucidated.
Chaoran Song, Mi-Yeon Kim, Jae Youl Cho
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Regulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle [PDF]
American Journal of Physiology-Cell Physiology, 2016 Vascular smooth muscle contraction is primarily regulated by phosphorylation of myosin light chain. There are also modulatory pathways that control the final level of force development. We tested the hypothesis that protein kinase C (PKC) and mitogen-activated protein (MAP) kinase modulate vascular smooth muscle activity via effects on MAP kinase ...
Danielle M, Trappanese +5 more
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The regulation of AP-1 activity by mitogen-activated protein kinases [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995 Abstract AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli.
M. Karin, Christopher John Marshall
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MAPK1 (mitogen-activated protein kinase 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on MAPK1 (mitogen-activated protein kinase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Tuncay, S, Banerjee, S
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Virulence, 2021 Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf +5 more
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