Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways [PDF]
Journal of Biological Chemistry, 2013 Mitogen-activated protein kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial role in the deactivation of MAPKs. Several drugs with immune-suppressive properties modulate MKP-1 expression as part of their mechanism of action. We investigated the effect of mTOR inhibition through rapamycin and a dual mTOR
Ruchi, Rastogi +9 more
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MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng +9 more
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Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]
F1000Research, 2022 The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy +5 more
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Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14 [PDF]
Animal Bioscience, 2023 Objective This study aims to evaluate the target genes of gga-miR-20a-5p and the regulated immune responses in the chicken macrophage cell line, HD11, by the exosome-mediated delivery of miR-20a-5p.
Yeojin Hong +5 more
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First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
IJU Case Reports, 2021 Introduction Ductal adenocarcinoma of the prostate is a rare prostate cancer variant and associated with higher stage and greater risk of mortality. Optimal systemic therapy for metastatic ductal adenocarcinoma is not known.
Kazunori Shojo +7 more
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Frontiers in Physiology, 2021 Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li +8 more
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Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases [PDF]
Oncogene, 2014 Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability and metabolism. Although these NAD(+)-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated signaling targets remain under-studied.
Yeung, Fan +9 more
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Journal of Pharmacological Sciences, 2009 .: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations ...
Sung Lyea Park +6 more
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A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
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Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions [PDF]
Cellular and Molecular Life Sciences, 2012 The balance of protein phosphorylation is achieved through the actions of a family of protein serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases (MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation.
Ahmed, Lawan +3 more
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