Results 31 to 40 of about 234,908 (267)
Mitogen-Activated Protein Kinase Phosphatase-1 Is Required for Cisplatin Resistance [PDF]
Cancer Research, 2006 Abstract Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is a member of the MKP family that negatively regulates MAPK signaling. MKP-1 has been implicated in cell survival in response to stressful stimuli, including anticancer treatment, but its role in cisplatin resistance is not fully understood.
Zhaoqing, Wang +4 more
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Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase‐1 in microglial cells [PDF]
Journal of Applied Toxicology, 2010 AbstractMultiple studies demonstrate that manganese (Mn) exposure potentiates inflammatory mediator output from activated glia; this increased output is associated with enhanced mitogen activated protein kinase (MAPK: p38, ERK and JNK) activity. We hypothesized that Mn activates MAPK by activating the kinases upstream of MAPK, i.e. MKK‐3/6, MKK‐1/2 and
Patrick L, Crittenden +1 more
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A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1
BMC Immunology, 2009 Background Mycobacterium tuberculosis (MTB) is a major cause of morbidity and mortality in the world. To combat against this pathogen, immune cells release cytokines including tumor necrosis factor-α (TNF-α), which is pivotal in the development of ...
Lau Allan SY +3 more
doaj +1 more source
Mitogen-Activated Protein Kinase Kinase 1 (MKK1) Is Negatively Regulated by Threonine Phosphorylation [PDF]
Molecular and Cellular Biology, 1994 Mitogen-activated protein kinase kinase 1 (MKK1), a dual-specificity tyrosine/threonine protein kinase, has been shown to be phosphorylated and activated by the raf oncogene product as part of the mitogen-activated protein kinase cascade. Here we report the phosphorylation and inactivation of MKK1 by phosphorylation on threonine 286 and threonine 292 ...
A J, Rossomando +3 more
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Frontiers in Molecular Neuroscience, 2021 Small non-coding vault RNAs (vtRNAs) have been described as a component of the vault complex, a hollow-and-barrel-shaped ribonucleoprotein complex found in most eukaryotes.
Shuji Wakatsuki, Toshiyuki Araki
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Mitogen-activated Protein Kinase Phosphorylates and Regulates the HIV-1 Vif Protein [PDF]
Journal of Biological Chemistry, 1998 The human immunodeficiency virus type 1 (HIV-1) Vif protein plays a critical role in virus replication and infectivity. Here we show that Vif is phosphorylated and regulated by p44/42 mitogen-activated protein kinase (MAPK). Vif phosphorylation by MAPK was demonstrated in vitro as well as in vivo and was shown to occur on serine and threonine residues.
X, Yang, D, Gabuzda
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Journal of Experimental & Clinical Cancer Research, 2019 Background Head and neck squamous-cell carcinoma (HNSCC) ranks sixth among cancers worldwide. Though several molecular mechanisms of tumor initiation and progression of HNSCC are known, others remain unclear.
Sourabh Soni +4 more
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Frontiers in Nutrition, 2022 Early weaning increased the economic benefits of piglets. However, early weaning damages the intestinal barrier of piglets and causes immunological stress.
Muyang Li +4 more
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Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 [PDF]
Molecular and Cellular Biology, 2001 Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 ...
U, Knauf, C, Tschopp, H, Gram
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Journal of Pharmacological Sciences, 2011 .: Oxidative stress is considered a major mediator of arteriosclerosis. In vascular smooth muscle cells, oxidative stress–induced cell death (including apoptosis) is probably related to arterial calcification in arteriosclerosis.
Jing Zhao +5 more
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