Results 211 to 220 of about 53,988 (240)

Activation of extracellular signal‐regulated protein kinase (ERK/MAP kinase) following CD28 cross‐linking: activation in cells lacking p56^lck

Tissue Antigens, 1995
Abstract: T lymphocytes require two signals for activation. Recognition of antigen/MHC complexes by the T cell receptor delivers the first signal, while a second signal, delivered by the cell surface receptors CD80 and/or CD86 binding to the T cell surface molecule CD28, has been shown to be effective for the initiation of effective T cell responses ...
A, August, B, Dupont
openaire   +2 more sources

Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
The role of sphingosine kinase (SPHK) in the dibutyryl cyclic AMP (dbcAMP)-induced granulocytic differentiation of HL60 cells was investigated. During differentiation, SPHK activity was increased, as were mRNA and protein levels of SPHK1, but not of SPHK2.
Masahiro, Koda, Takashi, Murate, Shulin, Wang, Kenji, Ohguchi, Sayaka, Sobue, Mika, Ikeda, Keiko, Tamiya-Koizumi, Yasuyuki, Igarashi, Yoshinori, Nozawa, Yoshiko, Banno   +9 more
openaire   +2 more sources

5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: Time dependence and regional differences

Brain Research, 2007
Brain serotonin 1A (5-HT1A) receptors play an important role in mood disorders and can modulate various intracellular signaling mechanisms. We previously reported that systemic administration of either full or partial 5-HT1A agonists increases neuroendocrine responses and that tandospirone, an azapirone partial agonist, can activate (phosphorylate ...
Crane, James W., Shimizua, Keiko, Carrascoa, Gonzalo A., Garciaa, Francisca, Jiab, Cuihong, Sullivana, Nicole R., D'Souzaa, Deborah N., Zhanga, Yahong, Van de Kara, Louis D., Mumaa, Nancy A., Battaglia, George   +10 more
openaire   +5 more sources

Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK)

Molecular and Cellular Biochemistry, 2001
Previously, we have reported that insulin induces the expression of the dual-specificity tyrosine phosphatase Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) and that this may represent a negative feedback mechanism to regulate insulin-stimulated MAP kinase activity.
J C, Byon, S S, Dadke, S, Rulli, A B, Kusari, J, Kusari   +4 more
openaire   +2 more sources

Role of intracellular Ca²⁺ and calmodulin/MAP kinase kinase/extracellular signal‐regulated protein kinase signalling pathway in the mitogenic and antimitogenic effect of nitric oxide in glia‐ and neurone‐derived cell lines

European Journal of Neuroscience, 2006
AbstractTo elucidate the mechanism of cell growth regulation by nitric oxide (NO) and the role played in it by Ca2+, we studied the relationship among intracellular Ca2+ concentration ([Ca2+]i), mitogen‐activated protein kinases [extracellular signal‐regulated protein kinase (ERK)] and proliferation in cell lines exposed to different levels of NO. Data
MEINI A, GARCIA JB, PESSINA GP, ALDINUCCI, CARLO, FROSINI, MARIA, PALMI, MITRI   +5 more
openaire   +4 more sources

Effects of glucocorticoids on activation of c-jun N-terminal, extracellular signal-regulated, and p38 MAP kinases in human pulmonary endothelial cells.

Biochemical pharmacology, 2001
Mitogen-activated protein kinases (MAPK) play a central role in signal transduction by regulating many nuclear transcription factors involved in inflammatory, immune, and proliferative responses. The aim of this study was to investigate, in human pulmonary endothelial cells, the effects of synthetic glucocorticosteroids on activation of c-jun N ...
Pelaia G, Cuda G, VATRELLA, Alessandro, Grembiale RD, De Sarro G, Maselli R, Costanzo FS, Avvedimento VE, Rotiroti D, Marsico SA   +9 more
openaire   +2 more sources

A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.

Biology of reproduction, 2013
Sperm capacitation is characterized by a series of significant biochemical and biophysical modifications. Unlike the case with most other mammalian species, ram spermatozoa are difficult to capacitate in vitro. We have already suggested that unusually high levels of intracellular phosphodiesterases would account for cAMP levels that are too low to ...
Carolina, Luna, Carmen, Colás, Rosaura, Pérez-Pé, José A, Cebrián-Pérez, Teresa, Muiño-Blanco   +4 more
openaire   +1 more source

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

Cancer research, 1998
Retinoic acid (RA) activated the extracellular signal-regulated kinase (ERK) 2 mitogen-activated protein kinase (MAPK) of HL-60 human myeloblastic leukemia cells before causing myeloid differentiation and cell cycle arrest associated with hypophosphorylation of the retinoblastoma (RB) tumor suppressor protein.
A, Yen, M S, Roberson, S, Varvayanis, A T, Lee   +3 more
openaire   +1 more source

Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy

Acta Pharmaceutica Sinica B, 2022
Liang Ouyang, Guan Wang, Lan Zhang
exaly  

Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation

International Journal of Molecular Sciences, 2023
Kim Chaekyun
exaly