Results 31 to 40 of about 53,988 (240)

Leishmania donovani Secretory Mevalonate Kinase Regulates Host Immune Response and Facilitates Phagocytosis

Frontiers in Cellular and Infection Microbiology, 2021
Summary StatementLeishmania secretes over 151 proteins during in vitro cultivation. Cellular functions of one such novel protein: mevalonate kinase is discussed here; signifying its importance in Leishmania infection.Visceral Leishmaniasis is a ...
Tanvir Bamra, Taj Shafi, Sushmita Das, Manjay Kumar, Manas Ranjan Dikhit, Ajay Kumar, Ashish Kumar, Kumar Abhishek, Krishna Pandey, Abhik Sen, Pradeep Das   +10 more
doaj   +1 more source

MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression

Frontiers in Cellular Neuroscience, 2017
The norepinephrine transporter (NET) mediates the clearance of norepinephrine (NE) from the extracellular space and is a target of therapeutic antidepressants and psychostimulants.
Ole V. Mortensen, Mads B. Larsen, Susan G. Amara   +2 more
doaj   +1 more source

Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis. [PDF]

PLoS ONE, 2015
Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial to ...
Faith Hannah Nutter, John L Haylor, Arif Khwaja   +2 more
doaj   +1 more source

Biliverdin Reductase: a Target for Cancer Therapy?

Frontiers in Pharmacology, 2015
Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways.
Peter eGibbs, Tihomir eMiralem, Mahin D Maines   +2 more
doaj   +1 more source

ncRNAs and polyphenols: new therapeutic strategies for hypertension

RNA Biology, 2022
Polyphenols have gained significant attention in protecting several chronic diseases, such as cardiovascular diseases (CVDs). Accumulating evidence indicates that polyphenols have potential protective roles for various CVDs.
Elham Shirazi-Tehrani, Alireza Chamasemani, Negar Firouzabadi, Marzieh Mousaei   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Urinary adhesion molecules with ERK signaling as predictive biomarkers for kidney stones: a pilot study

BMC Urology
Background Noninvasive diagnostic biomarkers should be researched to reduce the need for imaging and radiation exposure in patients with kidney stone disease.
Yi-Shiou Tseng, Hsing-I Tseng, Shang-Jen Chang, Po-Wen Ku, Jiann-Ming Wu, Huei-Pin Lai, Ting-Hui Chang, Yuan-Ju Lee   +7 more
doaj   +1 more source

Mycobacterium tuberculosis 6-kDa Early Secreted Antigenic Target (ESAT-6) protein downregulates Lipopolysaccharide induced c-myc expression by modulating the Extracellular Signal Regulated Kinases 1/2

BMC Immunology, 2007
Background Mycobacterium tuberculosis (Mtb) causes death of 2–3 million people every year. The persistence of the pathogenic mycobacteria inside the macrophage occurs through modulation of host cell signaling which allows them, unlike the other non ...
Mir Fayaz, Basu Sandip K, Giang Pham H, Ganguly Niladri, Siddiqui Imran, Sharma Pawan   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source