Results 21 to 30 of about 53,988 (240)

Accumulating microglia phagocytose injured neurons in hippocampal slice cultures: involvement of p38 MAP kinase. [PDF]

PLoS ONE, 2012
In this study, microglial migration and phagocytosis were examined in mouse organotypic hippocampal slice cultures, which were treated with N-methyl-D-aspartate (NMDA) to selectively injure neuronal cells.
Takahiro Katayama, Hayato Kobayashi, Toshiyuki Okamura, Yuko Yamasaki-Katayama, Tatsuya Kibayashi, Hiroshi Kimura, Keiko Ohsawa, Shinichi Kohsaka, Masabumi Minami   +8 more
doaj   +1 more source

MAPK/ERK and JNK pathways regulate lipid synthesis and cell growth of Chlamydomonas reinhardtii under osmotic stress, respectively

Scientific Reports, 2018
Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions.
Ahreum Yang, William I. Suh, Nam Kyu Kang, Bongsoo Lee, Yong Keun Chang   +4 more
doaj   +1 more source

Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases

Journal of Pharmacological Sciences, 2003
Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective.
Masanori Yoshizumi, Jun-ichi Abe, Koichiro Tsuchiya, Bradford C. Berk, Toshiaki Tamaki   +4 more
doaj   +1 more source

TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment

Cancer Medicine, 2020
Glioblastoma multiforme (GBM) is a cancer of the central nervous system with limited therapeutic outcomes. Infiltrating cancer cells are the contributing factor to high GBM malignancy.
Ying‐Fa Chen, Po‐Chang Shih, Hsiao‐Mei Kuo, San‐Nan Yang, Yen‐You Lin, Wu‐Fu Chen, Shiow‐Jyu Tzou, Hsin‐Tzu Liu, Nan‐Fu Chen   +8 more
doaj   +1 more source

Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils

Journal of Biomedical Science, 2005
The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by PAF and fMLP were due to Ca2 ...
Lee-Wei, Chen, Min-Wai, Lin, Ching-Mei, Hsu   +2 more
openaire   +2 more sources

Protein kinases mediate increment of the phosphorylation of cyclic AMP -responsive element binding protein in spinal cord of rats following capsaicin injection

Molecular Pain, 2005
Background Strong noxious stimuli cause plastic changes in spinal nociceptive neurons. Intracellular signal transduction pathways from cellular membrane to nucleus, which may further regulate gene expression by critical transcription factors, convey ...
Li Junfa, Lei Yongzhong, Zhang Xuan, Ma Long, Su Guangxiao, Wu Jing, Lin Qing, Fang Li   +7 more
doaj   +1 more source

Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways. [PDF]

PLoS ONE, 2011
BACKGROUND: Fucoidan extract (FE), an enzymatically digested compound with a low molecular weight, is extracted from brown seaweed. As a natural compound with various actions, FE is attractive, especially in Asian countries, for improving the therapeutic
Zhongyuan Zhang, Kiichiro Teruya, Hiroshi Eto, Sanetaka Shirahata   +3 more
doaj   +1 more source

Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes

Journal of Pharmacological Sciences, 2015
Salinomycin (SAL), a monocarboxylic polyether antibiotic isolated from Streptomyces albus, modulates various cellular responses, including proliferation, apoptosis, and inflammation.
Seon-Mi Yu, Song-Ja Kim
doaj   +1 more source

Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes

Marine Drugs, 2015
Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and ...
Yun-Hee Choi, Dong Joo Yang, Atul Kulkarni, Sang Hyun Moh, Ki Woo Kim   +4 more
doaj   +1 more source

Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. [PDF]

PLoS ONE, 2013
Hepatitis C virus (HCV) induced liver disease is the leading indication for liver transplantation (LTx). Reinfection and accelerated development of fibrosis is a universal phenomenon following LTx. The molecular events that lead to fibrosis following HCV
Sabarinathan Ramachandran, Haseeb Ilias Basha, Nayan J Sarma, Yiing Lin, Jeffrey S Crippin, William C Chapman, Thalachallour Mohanakumar   +6 more
doaj   +1 more source