Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
doaj +1 more source
Decreased Extracellular-Signal-Regulated Kinase and Increased Stress-Activated MAP Kinase Activities in Aged Human Skin In Vivo [PDF]
Journal of Investigative Dermatology, 2000 The ability of human skin to rejuvenate itself diminishes with the passage of time, resulting in increased fragility. This increased fragility reflects both reduced growth of skin cells and loss of collagenous connective tissue. Oxidative damage plays a central role in cellular aging.
Chung, Jin Ho +5 more
openaire +2 more sources
Interactions between extracellular signal-regulated kinase 1/2 and P38 Map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity [PDF]
Journal of Bone and Mineral Research, 2011 Abstract RUNX2, a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and p38 MAP kinase-mediated phosphorylation. However, the specific contribution of each kinase to RUNX2-dependent transcription is not known. Here we investigate ERK and p38 regulation of RUNX2 using a unique P-RUNX2-specific antibody.
Ge, Chunxi +5 more
openaire +4 more sources
The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond
Journal of Fungi, 2021 The survival of eukaryotic organisms during environmental changes is largely dependent on the adaptive responses elicited by signal transduction cascades, including those regulated by the Mitogen-Activated Protein Kinase (MAPK) pathways.
José Cansado +4 more
doaj +1 more source
Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis [PDF]
Diabetes & Metabolism Journal, 2023 Background Long non-coding RNAs (lncRNAs) have been illustrated to contribute to the development of gestational diabetes mellitus (GDM). In the present study, we aimed to elucidate how lncRNA taurine upregulated gene 1 (TUG1) influences insulin ...
Xuwen Tang +3 more
doaj +1 more source
Nuclear Shuttling of Mitogen-Activated Protein (MAP) Kinase (Extracellular Signal-Regulated Kinase (ERK) 2) Was Dynamically Controlled by MAP/ERK Kinase After Antigen Stimulation in RBL-2H3 Cells [PDF]
The Journal of Immunology, 2001 Abstract The mitogen-activated protein kinase (MAPK) cascade consists of the MAPK (extracellular signal-regulated kinase 2; ERK2) and its activator, MAPK kinase (MAP/ERK kinase; MEK). However, the mechanisms for activation of ERK2 have not been defined yet in cells.
T, Furuno +4 more
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Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation [PDF]
Investigative and Clinical Urology, 2019 Purpose: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression.
Hyun Sik Park +6 more
doaj +1 more source
The Mitogen-activated Protein (MAP) Kinases p38 and Extracellular Signal-regulated Kinase (ERK) Are Involved in Hepatocyte-mediated Phenotypic Switching in Prostate Cancer Cells [PDF]
Journal of Biological Chemistry, 2014 The greatest challenge for the seeding of cancer in metastatic sites is integration into the ectopic microenvironment despite the lack of an orthotopic supportive environment and presence of pro-death signals concomitant with a localized "foreign-body" inflammatory response.
Bo, Ma, Alan, Wells
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Anti-inflammatory effect of longan seed extract in carrageenan stimulated Sprague-Dawley rats [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Longan seeds have been used as a folk medicine in China. Longan seed extract (LSE) is known for antioxidative, antiproliferative, hypoglycemic, and hypouremic effects. However, its anti-inflammatory effect has not been shown.
Ching-Hsiao Lee +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2003 Mitogen-activated protein kinases (MAP kinases), including extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, play a central role in cellular responses by various stress stimuli such as cell proliferation, apoptosis ...
Shokei Kim, Hiroshi Iwao
doaj +1 more source