Current Techniques for Investigating the Brain Extracellular Space [PDF]
Frontiers in Neuroscience, 2020 The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions of its channels and ...
Federico N. Soria +6 more
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Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling [PDF]
Nature Communications, 2020 The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Federico N. Soria +11 more
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Protein Dynamics in the Plant Extracellular Space [PDF]
Proteomes, 2016 The extracellular space (ECS or apoplast) is the plant cell compartment external to the plasma membrane, which includes the cell walls, the intercellular space and the apoplastic fluid (APF).
Leonor Guerra-Guimarães +4 more
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Potential of extracellular space for tissue regeneration in dentistry [PDF]
Frontiers in Physiology, 2022 With the proven relationship between oral and general health and the growing aging population, it is pivotal to provide accessible therapeutic approaches to regenerate oral tissues and restore clinical function.
Anahid A. Birjandi, Paul Sharpe
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Mechanism of extracellular space changes in cryptococcal brain granuloma revealed by MRI tracer [PDF]
Frontiers in Neuroscience, 2022 PurposeThis study aimed to investigate the changes in extracellular space (ECS) in cryptococcal brain granuloma and its pathological mechanism.Materials and methodsThe animal model of cryptococcal brain granuloma was established by injecting 1 × 106 CFU ...
Nuerbiyemu Abulikemu +25 more
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Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex [PDF]
Advanced ScienceA hallmark of Alzheimer's disease (AD) is the accumulation of amyloid plaques, primarily composed of misfolded amyloid β (Aβ) peptides. Complementary high‐resolution imaging techniques are employed to investigate the plaque penetrability and the ...
Juan Estaún‐Panzano +11 more
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Nanoscale and functional heterogeneity of the hippocampal extracellular space
Cell Reports, 2023 Summary: The extracellular space (ECS) and its constituents play a crucial role in brain development, plasticity, circadian rhythm, and behavior, as well as brain diseases.
Diego Grassi +7 more
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An Isotonic Model of Neuron Swelling Based on Co-Transport of Salt and Water
Membranes, 2023 Neurons spend most of their energy building ion gradients across the cell membrane. During energy deprivation the neurons swell, and the concomitant mixing of their ions is commonly assumed to lead toward a Donnan equilibrium, at which the concentration ...
Reinoud Maex
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New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery
Pharmaceutics, 2023 Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein.
Haishu Chen +7 more
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Unconventional Pathways of Protein Secretion: Mammals vs. Plants
Frontiers in Cell and Developmental Biology, 2022 In eukaryotes, many proteins contain an N-terminal signal peptide that allows their translocation into the endoplasmic reticulum followed by secretion outside the cell according to the classical secretory system. However, an increasing number of secreted
Elisa Maricchiolo +5 more
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