Potential of extracellular space for tissue regeneration in dentistry [PDF]
Frontiers in Physiology, 2022 With the proven relationship between oral and general health and the growing aging population, it is pivotal to provide accessible therapeutic approaches to regenerate oral tissues and restore clinical function.
Anahid A. Birjandi, Paul Sharpe
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Current Techniques for Investigating the Brain Extracellular Space [PDF]
Frontiers in Neuroscience, 2020 The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions of its channels and ...
Federico N. Soria +6 more
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Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling [PDF]
Nature Communications, 2020 The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Federico N. Soria +11 more
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Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex [PDF]
Advanced ScienceA hallmark of Alzheimer's disease (AD) is the accumulation of amyloid plaques, primarily composed of misfolded amyloid β (Aβ) peptides. Complementary high‐resolution imaging techniques are employed to investigate the plaque penetrability and the ...
Juan Estaún‐Panzano +11 more
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Protein Dynamics in the Plant Extracellular Space [PDF]
Proteomes, 2016 The extracellular space (ECS or apoplast) is the plant cell compartment external to the plasma membrane, which includes the cell walls, the intercellular space and the apoplastic fluid (APF).
Leonor Guerra-Guimarães +4 more
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Microglia as hackers of the matrix: sculpting synapses and the extracellular space. [PDF]
Cell Mol Immunol, 2021 Microglia shape the synaptic environment in health and disease, but synapses do not exist in a vacuum. Instead, pre- and postsynaptic terminals are surrounded by extracellular matrix (ECM), which together with glia comprise the four elements of the ...
Crapser JD +3 more
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Diffusion in Brain Extracellular Space [PDF]
Physiological Reviews, 2008 Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules in the brain. Deviations from the equation reveal loss of molecules across the blood-brain barrier, through cellular uptake, binding, or other mechanisms ...
Eva, Syková, Charles, Nicholson
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Mechanism of extracellular space changes in cryptococcal brain granuloma revealed by MRI tracer [PDF]
Frontiers in Neuroscience, 2022 PurposeThis study aimed to investigate the changes in extracellular space (ECS) in cryptococcal brain granuloma and its pathological mechanism.Materials and methodsThe animal model of cryptococcal brain granuloma was established by injecting 1 × 106 CFU ...
Nuerbiyemu Abulikemu +25 more
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Local diffusion in the extracellular space of the brain
Neurobiology of Disease, 2023 The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological complexity, composed of narrow gaps separated by local expansions, enabling interconnected highways between neural cells.
Jan Tønnesen +2 more
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Brain Extracellular Space: The Final Frontier of Neuroscience. [PDF]
Biophys J, 2017 Nicholson C, Hrabětová S.
europepmc +4 more sources