Results 1 to 10 of about 344,575 (257)

Nanoscale and functional heterogeneity of the hippocampal extracellular space [PDF]

Cell Reports, 2023
Summary: The extracellular space (ECS) and its constituents play a crucial role in brain development, plasticity, circadian rhythm, and behavior, as well as brain diseases.
Diego Grassi, Agata Idziak, Antony Lee, Ivo Calaresu, Jean-Baptiste Sibarita, Laurent Cognet, U. Valentin Nägerl, Laurent Groc   +7 more
doaj   +3 more sources

Potential of extracellular space for tissue regeneration in dentistry [PDF]

Frontiers in Physiology, 2022
With the proven relationship between oral and general health and the growing aging population, it is pivotal to provide accessible therapeutic approaches to regenerate oral tissues and restore clinical function.
Anahid A. Birjandi, Paul Sharpe
doaj   +2 more sources

Mechanism of extracellular space changes in cryptococcal brain granuloma revealed by MRI tracer [PDF]

Frontiers in Neuroscience, 2022
PurposeThis study aimed to investigate the changes in extracellular space (ECS) in cryptococcal brain granuloma and its pathological mechanism.Materials and methodsThe animal model of cryptococcal brain granuloma was established by injecting 1 × 106 CFU ...
Nuerbiyemu Abulikemu, Nuerbiyemu Abulikemu, Nuerbiyemu Abulikemu, Xin Gao, Wei Wang, Qingyuan He, Qingyuan He, Qingyuan He, Gang Wang, Gang Wang, Tao Jiang, Xiaodong Wang, Yumeng Cheng, Yumeng Cheng, Min Chen, Yanran Li, Lulu Liu, Jingjing Zhao, Jin Li, Chunhui Jiang, Yunling Wang, Hongbin Han, Hongbin Han, Hongbin Han, Jian Wang, Jian Wang   +25 more
doaj   +2 more sources

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex [PDF]

Advanced Science
A hallmark of Alzheimer's disease (AD) is the accumulation of amyloid plaques, primarily composed of misfolded amyloid β (Aβ) peptides. Complementary high‐resolution imaging techniques are employed to investigate the plaque penetrability and the ...
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
doaj   +2 more sources

Current Techniques for Investigating the Brain Extracellular Space [PDF]

Frontiers in Neuroscience, 2020
The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions of its channels and ...
Federico N. Soria, Federico N. Soria, Cristina Miguelez, Cristina Miguelez, Olga Peñagarikano, Jan Tønnesen, Jan Tønnesen   +6 more
doaj   +2 more sources

Local diffusion in the extracellular space of the brain

Neurobiology of Disease, 2023
The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological complexity, composed of narrow gaps separated by local expansions, enabling interconnected highways between neural cells.
Jan Tønnesen, Sabina Hrabĕtová, Federico N. Soria   +2 more
doaj   +2 more sources

Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space. [PDF]

Cell Death Discov, 2023
Yu TG, Cha JS, Kim G, Sohn YK, Yoo Y, Kim U, Song JJ, Cho HS, Kim HS.   +8 more
europepmc   +3 more sources

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling [PDF]

Nature Communications, 2020
The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard   +11 more
doaj   +2 more sources

Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter. [PDF]

J Physiol, 2021
Colbourn R, Hrabe J, Nicholson C, Perkins M, Goodman JH, Hrabetova S.   +5 more
europepmc   +3 more sources

Unassembled cell wall proteins form aggregates in the extracellular space of Chlamydomonas reinhardtii strain UVM4. [PDF]

Appl Microbiol Biotechnol, 2022
Barolo L, Commault AS, Abbriano RM, Padula MP, Kim M, Kuzhiumparambil U, Ralph PJ, Pernice M.   +7 more
europepmc   +3 more sources