Results 1 to 10 of about 2,697 (69)
Nanoscale and functional heterogeneity of the hippocampal extracellular space
Cell Reports, 2023 Summary: The extracellular space (ECS) and its constituents play a crucial role in brain development, plasticity, circadian rhythm, and behavior, as well as brain diseases.
Diego Grassi +7 more
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An Isotonic Model of Neuron Swelling Based on Co-Transport of Salt and Water
Membranes, 2023 Neurons spend most of their energy building ion gradients across the cell membrane. During energy deprivation the neurons swell, and the concomitant mixing of their ions is commonly assumed to lead toward a Donnan equilibrium, at which the concentration ...
Reinoud Maex
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New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery
Pharmaceutics, 2023 Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein.
Haishu Chen +7 more
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Unconventional Pathways of Protein Secretion: Mammals vs. Plants
Frontiers in Cell and Developmental Biology, 2022 In eukaryotes, many proteins contain an N-terminal signal peptide that allows their translocation into the endoplasmic reticulum followed by secretion outside the cell according to the classical secretory system. However, an increasing number of secreted
Elisa Maricchiolo +5 more
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Potential of extracellular space for tissue regeneration in dentistry
Frontiers in Physiology, 2022 With the proven relationship between oral and general health and the growing aging population, it is pivotal to provide accessible therapeutic approaches to regenerate oral tissues and restore clinical function.
Anahid A. Birjandi, Paul Sharpe
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Frontiers in Oncology, 2023 ObjectivesTo evaluate whether tumor extracellular volume fraction (fECV) on contrast-enhanced computed tomography (CT) aids in the differentiation between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).MethodsIn this ...
T. Honda +12 more
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Frontiers in Neurology, 2021 Interictal spikes (IISs) may result from a disturbance of the intimate functional balance between various neuronal (synaptic and non-synaptic), vascular, and metabolic compartments.
Cristian Arnal-Real +4 more
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Mechanism of extracellular space changes in cryptococcal brain granuloma revealed by MRI tracer
Frontiers in Neuroscience, 2022 PurposeThis study aimed to investigate the changes in extracellular space (ECS) in cryptococcal brain granuloma and its pathological mechanism.Materials and methodsThe animal model of cryptococcal brain granuloma was established by injecting 1 × 106 CFU ...
Nuerbiyemu Abulikemu +25 more
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The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance
Biomolecules, 2019 The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs)
Eliska Ruzickova +4 more
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Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form
Immuno, 2021 Peptidases generate bioactive peptides that can regulate cell signaling and mediate intercellular communication. While the processing of peptide precursors is initiated intracellularly, some modifications by peptidases may be conducted extracellularly ...
Yu Liu +3 more
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