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Current Techniques for Investigating the Brain Extracellular Space [PDF]
Frontiers in Neuroscience, 2020 The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions of its channels and ...
Federico N. Soria +6 more
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Local diffusion in the extracellular space of the brain
Neurobiology of Disease, 2023 The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological complexity, composed of narrow gaps separated by local expansions, enabling interconnected highways between neural cells.
Jan Tønnesen +2 more
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Protein Dynamics in the Plant Extracellular Space [PDF]
Proteomes, 2016 The extracellular space (ECS or apoplast) is the plant cell compartment external to the plasma membrane, which includes the cell walls, the intercellular space and the apoplastic fluid (APF).
Leonor Guerra-Guimarães +4 more
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Diffusion in Brain Extracellular Space [PDF]
Physiological Reviews, 2008 Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules in the brain. Deviations from the equation reveal loss of molecules across the blood-brain barrier, through cellular uptake, binding, or other mechanisms ...
Eva Syková, Charles Nicholson
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Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling [PDF]
Nature Communications, 2020 The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Federico N. Soria +11 more
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Diffusion in the extracellular space in brain and tumors [PDF]
Physical Biology, 2013 Diffusion of solutes and macromolecules in the extracellular space (ECS) in brain is important for non-synaptic intercellular communication, extracellular ionic buffering, and delivery of drugs and metabolites. Diffusion in tumor ECS is important for delivery of anti-tumor drugs.
A. S. Verkman
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The Extracellular Space of Voluntary Muscle Tissues [PDF]
The Journal of General Physiology, 1967 The volume occupied by the extracellular space has been investigated in six types of voluntary muscles: sartorius (frog), semitendinosus (frog), tibialis anticus longus (frog), iliofibularis (frog), rectus abdominis (frog), and diaphragm (rat). With the aid of four types of probe material, three of which are conventionally employed (inulin, sorbitol ...
Gilbert N. Ling, Marsha H. Kromash
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Determination of Extracellular Space in Amphibian Muscle [PDF]
The Journal of General Physiology, 1967 The volumes of distribution of inulin and dextran in the sartorius, stomach, and cardiac muscle of the frog agree rather closely. That these spaces represent the volume of extracellular water is supported by the observation that efflux of sucrose can be divided into a fast and a slow phase and that the fast-moving fraction corresponds closely with ...
Emil Bozler
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Extracellular space preservation aids the connectomic analysis of neural circuits
eLife, 2015 Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant ...
Marta Pallotto +4 more
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Extracellular space in some isolated tissues [PDF]
The Journal of Physiology, 1974 1. The spaces occupied by isotopically labelled inulin, polyethylene glycol, mol. wt. 4000 (PEG 4000), polyethylene glycol, mol. wt. 1000 (PEG 1000) and sucrose in metabolizing mammalian kidney and liver slices and in toad bladder epithelial cell preparations incubated in vitro have been examined.2.
Donald J.L. McIver +1 more
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