Studying the extracellular contribution to the double wave vector diffusion-weighted signal
Current Directions in Biomedical Engineering, 2015 The use of two independent diffusion periods between excitation and acquisition, known as double wave vector (DWV) diffusion-weighting or double diffusion encoding, was proven to yield structural information that it is otherwise not easily available in ...
Ulloa Patricia +2 more
doaj +1 more source
Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus. [PDF]
, 2015 Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy.
Binder, Devin K +5 more
core +3 more sources
Release of podocalyxin into the extracellular space
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 Podocalyxin (PODXL) is a type I membrane mucoprotein abundantly presented in the epithelial cells (podocytes) of kidney glomeruli where it plays an important role in maintaining the plasma filtration. PODXL is also expressed in other types of cells but its function is ignored.
Fernández, Darío +5 more
openaire +4 more sources
The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging
DiagnosticsBackground/Objectives: The objective of this study was to investigate the association between congestive heart failure (CHF) and T1 mapping in both liver lobes using cardiac MRI.
Adrian T. Huber +21 more
doaj +1 more source
Extracellular space preservation aids the connectomic analysis of neural circuits
eLife, 2015 Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant ...
Marta Pallotto +4 more
doaj +1 more source
Tumor interstitial fluid formation, characterization and clinical implications
Frontiers in Oncology, 2015 The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment.
Marek eWagner, Helge eWiig
doaj +1 more source
Understanding Multicellularity: The Functional Organization of the Intercellular Space [PDF]
, 2019 The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration,
Bich, Leonardo +2 more
core +8 more sources
Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
Cells, 2019 For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak +3 more
doaj +1 more source
Electrodiffusive model for astrocytic and neuronal ion concentration dynamics. [PDF]
PLoS Computational Biology, 2013 The cable equation is a proper framework for modeling electrical neural signalling that takes place at a timescale at which the ionic concentrations vary little.
Geir Halnes +4 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source