Results 51 to 60 of about 247,522 (191)
Frontiers in Neural Circuits, 2017 Neural circuit activity increases the release of the purine neuromodulator adenosine into the extracellular space leading to A1 receptor activation and negative feedback via membrane hyperpolarization and inhibition of transmitter release.
Rebecca Diez +2 more
doaj +1 more source
eLife, 2020 Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement.
Travis A Babola +3 more
doaj +1 more source
ERJ Open Research, 2021 Introduction Evidence suggests that abnormalities occur in the lung microvasculature in idiopathic pulmonary fibrosis (IPF). We hypothesised that dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) could detect alterations in permeability ...
Sydney B. Montesi +8 more
doaj +1 more source
Emergent Properties of Tumor Microenvironment in a Real-life Model of Multicell Tumor Spheroids [PDF]
, 2010 Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the internal workings ...
A Cornish-Bowden +46 more
core +6 more sources
In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity
Redox Biology, 2022 Hydrogen peroxide is a major redox signaling molecule underlying a novel paradigm of cell function and communication. A role for H2O2 as an intercellular signaling molecule and neuromodulator in the brain has become increasingly apparent, with evidence ...
A. Ledo +4 more
doaj +1 more source
The Dimensions of the Extracellular Space in Sartorius Muscle [PDF]
The Journal of General Physiology, 1959 A survey has been made of the amount of muscle water available to inulin, sucrose, and radioiodinated human serum albumin (RISA). The percentage spaces available to the three molecules are of the same order of magnitude, but the sucrose space > inulin space > albumin space.
F. H. Shaw +4 more
openaire +3 more sources
A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
, 2012 We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid.
Graben, Peter beim, Rodrigues, Serafim
core +2 more sources
MetaboTools: A comprehensive toolbox for analysis of genome-scale metabolic models [PDF]
, 2016 Metabolomic data sets provide a direct read-out of cellular phenotypes and are increasingly generated to study biological questions. Our previous work revealed the potential of analyzing extracellular metabolomic data in the context of the metabolic ...
Aurich, Maike K. +2 more
core +3 more sources
Advanced Science, 2022 The numerous biological barriers, which limit pharmacotherapy of pancreatic carcinoma, including inadequate drug accumulation in the tumor environment, a dense extracellular matrix (ECM) and efficient drug‐efflux mechanisms, illustrate the requirement of
Taotao Huo +9 more
doaj +1 more source
Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications [PDF]
, 2009 Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid.
A Bertuzzi +49 more
core +1 more source