Results 221 to 230 of about 44,900 (251)

Extracellular traps in kidney disease

Kidney International, 2018
During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage.
Nakazawa, Daigo, Marschner, Julian A., Platen, Louise, Anders, Hans-Joachim   +3 more
openaire   +2 more sources

Eosinophils: Focus on DNA extracellular traps

Life Sciences, 2022
Eosinophils are multitasking granulocytes with implications for allergies, host response to helminths and, more recently, described roles in immunomodulation, homeostasis and tissue remodeling. Eosinophils secrete their preformed granule proteins by different pathways, especially piecemeal degranulation and cytolysis with granule release.
Glaucia A, Thompson-Souza, Claudia Regina Isaías, Vasconcelos, Josiane S, Neves   +2 more
openaire   +2 more sources

Neutrophil Extracellular Traps Kill Bacteria

Science, 2004
Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D., Weinrauch, Y., Zychlinsky, A.   +7 more
openaire   +4 more sources

Neutrophil Extracellular Traps in Sepsis

Shock, 2014
Sepsis is the leading cause of death in critically ill patients in intensive care units. Early recognition of sepsis and proper therapy are essential to reduce patient mortality. Moreover, treatment options for this deleterious inflammatory response to infection are limited.
Camicia, Gabriela Lorena, Pozner, Roberto Gabriel, de Larrañaga, Gabriela Fernanda   +2 more
openaire   +3 more sources

Neutrophil Extracellular Trap in Human Diseases

2012
NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill ...
Magdalena, Arazna, Michal P, Pruchniak, Katarzyna, Zycinska, Urszula, Demkow   +3 more
openaire   +2 more sources

A new tool for detection of extracellular traps

Methods and Applications in Fluorescence, 2018
Extracellular traps ejected by various immune cells (neutrophils, macrophages, eosinophils and mast cells) have several immune functions, either protective against pathogens or deleterious in some autoimmune or inflammatory disorders. Since their first description in 2004, the mechanisms of extracellular traps formation have been extensively ...
Alizé Proust, Julie-Christine Lévesque, Corinne Barat, Sachiko Sato, Michel J Tremblay   +4 more
openaire   +2 more sources

Visualization of neutrophil extracellular traps in TEM

Micron, 2008
Neutrophil extracellular traps (NETs) have recently been described as an important innate defence mechanism in inflammation. However, routine electron microscopic staining techniques faintly stain NETs and are therefore insufficient for enabling a distinction between these and the host cell debris as well as proteins regularly present at the site of ...
Wolf Dietrich, Krautgartner, Ljubomir, Vitkov   +1 more
openaire   +2 more sources

Neutrophil Extracellular Traps in Periodontitis

Journal of Dental Research, 2015
Neutrophil extracellular traps (NETs) represent a novel paradigm in neutrophil-mediated immunity. NETs are believed to constitute a highly conserved antimicrobial strategy comprising decondensed nuclear DNA and associated histones that are extruded into the extracellular space.
P C, White, I J, Chicca, P R, Cooper, M R, Milward, I L C, Chapple   +4 more
openaire   +2 more sources

Induction and Quantification of Neutrophil Extracellular Traps

2014
Neutrophil extracellular trap (NET) formation is a recently discovered process in the field of innate immunity. It is important to have consistent standards in inducing and quantifying NET formation to compare data from different labs in this new area of investigation.
Sanchez Gonzalez, A., Bardoel, B., Harbort, C., Zychlinsky, A.   +3 more
openaire   +3 more sources

Impact of resveratrol on neutrophil extracellular traps

Mutation Research - Reviews in Mutation Research
Neutrophil extracellular traps (NETs) and the process of NETosis have emerged as critical participants in various pathological conditions. Resveratrol, a natural polyphenol found in several plants, has received significant attention due to its potential therapeutic properties.
Mahboobeh Ghasemzadeh Rahbardar, Prashant Kesharwani, Amirhossein Sahebkar   +2 more
openaire   +2 more sources