Results 31 to 40 of about 44,900 (251)

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

Haematologica, 2013
Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps.
Marein Schimmel, Erfan Nur, Bart J. Biemond, Gerard J. van Mierlo, Shabnam Solati, Dees P. Brandjes, Hans-Martin Otten, John-John Schnog, Sacha Zeerleder   +8 more
doaj   +1 more source

Neutrophil Extracellular Traps, Angiogenesis and Cancer

Biomedicines, 2022
Human neutrophils, the most abundant circulating leukocytes, are fundamental components of the host response against different pathogens. Until a few years ago, neutrophils received limited attention in cancer immunology. Recently, it was discovered that
Remo Poto, Leonardo Cristinziano, Luca Modestino, Amato de Paulis, Gianni Marone, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi   +7 more
doaj   +1 more source

Neutrophil Extracellular Traps in the Autoimmunity Context [PDF]

Frontiers in Medicine, 2021
The formation of neutrophil extracellular traps (NETs) is a strategy utilized by neutrophils for capturing infective agents. Extracellular traps consist in a physical net made of DNA and intracellular proteins externalized from neutrophils, where bacteria and viruses are entrapped and killed by proteolysis.
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Angelo Manfredi, Giuseppe A. Ramirez, Pasquale Esposito, Simone Negrini, Barbara Trezzi, Giacomo Emmi, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri, Gian Marco Ghiggeri   +27 more
openaire   +6 more sources

Neutrophil Extracellular Traps [PDF]

, 2019
Neutrophil extracellular traps (NETs) are made of a network of extracellular strings of DNA that bind pathogenic microbes. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms. Reactive oxygen species generated by the neutrophil NADPH oxidase have been shown to be essential to mediate NET ...
openaire   +2 more sources

Neutrophil extracellular traps in sheep mastitis [PDF]

Veterinary Research, 2015
Neutrophil extracellular traps (NETs) are structures composed of DNA, histones, and antimicrobial proteins that are released extracellularly by neutrophils and other immune cells as a means for trapping and killing invading pathogens. Here, we describe NET formation in milk and in mammary alveoli of mastitic sheep, and provide a dataset of proteins ...
Pisanu S., Cubeddu T., Pagnozzi D., Rocca S., Cacciotto C., Alberti A., Marogna G., Uzzau S., Addis M. F.   +8 more
openaire   +3 more sources

Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis [PDF]

, 2020
AbstractDespite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo neutrophil extracellular trap (
Thomas M, Hofbauer, Anna S, Ondracek, Irene M, Lang   +2 more
openaire   +2 more sources

Evolution of neutrophil extracellular traps in the pathology of stroke

Neural Regeneration Research
Stroke is a major cause of death and disability worldwide, and its pathogenesis is complex, involving multiple pathological processes, such as thrombosis, ischemia-reperfusion injury, inflammatory response, and blood–brain barrier disruption.
Wenjing Ning, Qian Wang, Yuzhen Xu
doaj   +1 more source

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

Haematologica, 2017
Neutrophils, early mediators of the innate immune defense, are recruited to developing thrombi in different types of thrombosis. They amplify intravascular coagulation by stimulating the tissue factor-dependent extrinsic pathway via inactivation of ...
Susanne Pfeiler, Konstantin Stark, Steffen Massberg, Bernd Engelmann   +3 more
doaj   +1 more source

Formation of Extracellular Traps - the Effective Mechanism of Organism Protection from Pathogen

Проблемы особо опасных инфекций, 2012
Summarized and analyzed are modern literature data on capability of cells (neutrophils, eosinophils and labrocytes) realizing the mechanisms of innate immunity, to form extracellular traps that capture and kill pathogens by secretion of DNA and ...
A. L. Kravtsov
doaj   +1 more source

Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions.
Jianbo Lou, Jianning Zhang, Quanjun Deng, Xin Chen   +3 more
doaj   +1 more source