Extracellular vesicles in parasitic diseases [PDF]
Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions.
Marcilla, Antonio+8 more
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Multiscale Dynamics of Lipid Vesicles in Polymeric Microenvironment [PDF]
Understanding dynamic and complex interaction of biological membranes with extracellular matrices plays a crucial role in controlling a variety of cell behavior and functions, from cell adhesion and growth to signaling and differentiation. Tremendous interest in tissue engineering has made it possible to design polymeric scaffolds mimicking the ...
arxiv +1 more source
Extracellular vesicles in food biotechnology [PDF]
Peer ...
Morales, Pilar+7 more
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Machine Learning Characterization of Cancer Patients-Derived Extracellular Vesicles using Vibrational Spectroscopies [PDF]
The early detection of cancer is a challenging problem in medicine. The blood sera of cancer patients are enriched with heterogeneous secretory lipid bound extracellular vesicles (EVs), which present a complex repertoire of information and biomarkers, representing their cell of origin, that are being currently studied in the field of liquid biopsy and ...
arxiv +1 more source
Machine Intelligence-Driven Classification of Cancer Patients-Derived Extracellular Vesicles using Fluorescence Correlation Spectroscopy: Results from a Pilot Study [PDF]
Patient-derived extracellular vesicles (EVs) that contains a complex biological cargo is a valuable source of liquid biopsy diagnostics to aid in early detection, cancer screening, and precision nanotherapeutics. In this study, we predicted that coupling cancer patient blood-derived EVs to time-resolved spectroscopy and artificial intelligence (AI ...
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Abstract Extracellular vesicles (EVs) encompass a diverse array of membrane-bound organelles released outside cells in response to developmental and physiological cell needs. EVs play important roles in remodeling the shape and content of differentiating cells and can rescue damaged cells from toxic or dysfunctional content. EVs can send
Juan Wang, Maureen M Barr, Ann M Wehman
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Towards rapid extracellular vesicles colorimetric detection using optofluidics-enhanced color-changing optical metasurface [PDF]
Efficient transportation and delivery of analytes to the surface of optical sensors are crucial for overcoming limitations in diffusion-limited transport and analyte sensing. In this study, we propose a novel approach that combines metasurface optics with optofluidics-enabled active transport of extracellular vesicles (EVs).
arxiv +1 more source
Extracellular Vesicles as Regulators of the Extracellular Matrix
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which ...
Neil J. Patel+2 more
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Quality of approximating a mass-emitting object by a point source in a diffusion model [PDF]
For the sake of computational efficiency and for theoretical purposes, in mathematical modelling, the Dirac Delta distributions are often utilized as a replacement for cells or vesicles, since the size of cells or vesicles is much smaller than the size of the surrounding tissues.
arxiv +1 more source
AOC; Assembling Overlapping Communities [PDF]
Through discovery of meso-scale structures, community detection methods contribute to the understanding of complex networks. Many community finding methods, however, rely on disjoint clustering techniques, in which node membership is restricted to one community or cluster.
arxiv +1 more source