Results 21 to 30 of about 236,767 (310)

Exomap1 mouse: A transgenic model for in vivo studies of exosome biology

Extracellular Vesicle, 2023
Exosomes are small extracellular vesicles (sEVs) of ∼30–150 nm in diameter that are enriched in exosome marker proteins and play important roles in health and disease.
Francis K. Fordjour, Sarah Abuelreich, Xiaoman Hong, Emeli Chatterjee, Valeria Lallai, Martin Ng, Andras Saftics, Fengyan Deng, Natacha Carnel-Amar, Hiroaki Wakimoto, Kazuhide Shimizu, Malia Bautista, Tuan Anh Phu, Ngan K. Vu, Paige C. Geiger, Robert L. Raffai, Christie D. Fowler, Saumya Das, Lane K. Christenson, Tijana Jovanovic-Talisman, Stephen J. Gould   +20 more
doaj   +1 more source

Extracellular RNA in oncogenesis, metastasis and drug resistance

RNA Biology
Extracellular vesicles and nanoparticles (EVPs) are now recognized as a novel form of cell–cell communication. All cells release a wide array of heterogeneous EVPs with distinct protein, lipid, and RNA content, dependent on the pathophysiological state ...
Hannah Nelson, Sherman Qu, Jeffrey L. Franklin, Qi Liu, Heather H. Pua, Kasey C. Vickers, Alissa M. Weaver, Robert J. Coffey, James G. Patton   +8 more
doaj   +1 more source

Engineered IL-15/IL-15Rα-expressing cellular vesicles promote T cell anti-tumor immunity

Extracellular Vesicle, 2023
Interleukin 15 (IL-15) is a pivotal immune cytokine that responses to cancer stress signals and maintains tissue-resident memory T (TRM) cells. It is therefore considered as a potent therapeutic immunomodulator agonist cancer. However, in addition to the
Wenli Fang, Liyan Li, Zhongda Lin, Yuli Zhang, Zhangyan Jing, Yuan Li, Zhirang Zhang, Linlin Hou, Xin Liang, Xingding Zhang, Xudong Zhang   +10 more
doaj   +1 more source

Secreted exosomes induce filopodia formation

eLife
Filopodia are dynamic adhesive cytoskeletal structures that are critical for directional sensing, polarization, cell-cell adhesion, and migration of diverse cell types. Filopodia are also critical for neuronal synapse formation.
Caitlin McAtee, Mikin R Patel, Daisuke Hoshino, Bong Hwan Sung, Ariana K von Lersner, Mingjian Shi, Nan Hyung Hong, Anna Young, Evan Krystofiak, Andries Zijlstra, Alissa M Weaver   +10 more
doaj   +1 more source

Extracellular vesicle-embedded materials

Journal of Controlled Release, 2023
Extracellular vesicles (EVs) are small membrane-bound vesicles released by cells. EVs are emerging as a promising class of therapeutic entity that could be adapted in formulation due to their lack of immunogenicity and targeting capabilities. EVs have been shown to have similar regenerative and therapeutic effects to their parental cells and also have ...
Ma, Yingchang, Brocchini, Steve, Williams, Gareth R   +2 more
openaire   +3 more sources

A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)

eLife
Recent studies showed an unexpected complexity of extracellular vesicle (EV) biogenesis pathways. We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc.
Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas   +14 more
doaj   +1 more source

Extracellular Vesicles in Phylogeny

International Journal of Molecular Sciences, 2023
Extracellular vesicles (EVs) are cell-derived lipid vesicles in a size range of 20–1000 nm; often, these are classified as smaller and larger EVs in the literature or also commonly called small EVs (“exosomes”) and medium/large EVs (“microvesicles”) [...]
openaire   +2 more sources

Boosting extracellular vesicle secretion

Biotechnology Advances, 2022
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID-19, as well as promoting tissue regeneration in various conditions, including cardiomyopathies and spinal cord injuries.
Debbi, Lior, Guo, Shaowei, Safina, Dina, Levenberg, Shulamit   +3 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Exofection by exosomes: A transient functional cargo transfer

Extracellular Vesicle
Exosomes have emerged as key mediators of inter-cellular communication, transporting a diverse array of cargos that can reflect the current biological state of the cell.
Ramkumar Menon, Madhuri Tatiparthy, Jessica Selim, Isidore Mushimiyimana, Brinley Harrington, Awanit Kumar, Lauren Richardson, Emmanuel Amabebe, Ananth Kumar Kammala   +8 more
doaj   +1 more source