Results 41 to 50 of about 1,588,316 (303)

Metalloproteinases in extracellular vesicles

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communications in local and distant microenvironments under patho/physiological conditions. EVs contain bioactive materials such as proteins, RNA transcripts, microRNAs and even DNAs, and recent work on their protein profiles has revealed the existence of metalloproteinases
Masayuki, Shimoda, Rama, Khokha
openaire   +2 more sources

Dosing extracellular vesicles

Advanced Drug Delivery Reviews, 2021
Extracellular vesicles (EVs) are natural nanoparticles containing biologically active molecules. They are important mediators of intercellular communication and can be exploited therapeutically by various bioengineering approaches. To accurately determine the therapeutic potential of EVs in pre-clinical and clinical settings, dependable dosing ...
Dhanu, Gupta, Antje Maria, Zickler, Samir, El Andaloussi   +2 more
openaire   +2 more sources

Analysis of extracellular vesicle DNA at the single‐vesicle level by nano‐flow cytometry

Journal of Extracellular Vesicles, 2022
It has been demonstrated recently that extracellular vesicles (EVs) carry DNA; however, many fundamental features of DNA in EVs (EV‐DNA) remain elusive.
Haisheng Liu, Ye Tian, Cheng-Feng Xue, Qian Niu, Chen Chen, Xiao-Mei Yan   +5 more
semanticscholar   +1 more source

Supplementary Table from Highly Sensitive EGFRvIII Detection in Circulating Extracellular Vesicle RNA of Glioma Patients

, 2022
Supplementary Table from Highly Sensitive EGFRvIII Detection in Circulating Extracellular Vesicle RNA of Glioma ...
Yulia B. Rosenfeld (15042737), Bob S. Carter (15042746), Koushik Muralidharan (15042725), Sirena K. Khanna (15042740), Sarah Falotico (15042731), Syeda Maheen Batool (15042722), Tiffany Hsia (15042728), Leonora Balaj (15042743), Austin S. Gamblin (15042734)   +8 more
core   +3 more sources

Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells

Nature Communications, 2021
Extracellular vesicles (EVs), including exosomes, are thought to mediate intercellular communication through the transfer of cargoes from donor to acceptor cells.
Émeline Bonsergent, Eleonora Grisard, Julian Buchrieser, O. Schwartz, C. Théry, G. Lavieu   +5 more
semanticscholar   +1 more source

Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials

Extracellular Vesicle, 2022
Mortality and morbidity of cardiovascular diseases (CVDs) including ischemic heart disease (IHD) and heart failure (HF) are arising worldwide. Once cardiomyocyte is impaired, it is challenging to regenerate which is largely limited by the irreversibility
Xuerui Chen, Liyun Zhu, Jianyun Liu, Yi Lu, Longlu Pan, Junjie Xiao   +5 more
doaj   +1 more source

Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples

Journal of Extracellular Vesicles, 2022
Background: The ability to isolate extracellular vesicles (EVs) from blood is vital in the development of EVs as disease biomarkers. Both serum and plasma can be used, but few studies have compared these sources in terms of the type of EVs that are ...
N. Karimi, R. Dalirfardouei, Tomas S. Dias, J. Lötvall, C. Lässer   +4 more
semanticscholar   +1 more source

The interactions between extracellular vesicles and mesenchymal stem cells: Their potential roles in osteoarthritis development and cartilage repair

Extracellular Vesicle, 2022
Osteoarthritis (OA) is a chronic cartilage degeneration disease affecting total joint and with a wide global impact. Stem cell therapy has emerged as a potential stock for the treatment of OA.
Qiong Yang, Danyang Yue, Qian Ren, Guoqing Xia, Baihui Zhang, Yinyin Qin, Tianfei Ran, Min Wang, Li Pei, Jun Pan   +9 more
doaj   +1 more source

Understanding the extracellular vesicle surface for clinical molecular biology

Journal of Extracellular Vesicles, 2022
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant roles in health and disease. EVs are abundant in body fluids and carry an array of molecules (proteins, lipids, nucleic acids and glycans) that reflect the ...
S. Hallal, Á. Tűzesi, G. Grau, M. Buckland, Kimberley L. Alexander   +4 more
semanticscholar   +1 more source

PD-L1 antibodies-armed exosomal vaccine for enhanced cancer immunotherapy by simultaneously in situ activating T cells and blocking PD-1/PD-L1 axis

Extracellular Vesicle, 2022
Tumor immunotherapy significantly rewards antigen-specific T-cell responses, which have been recognized as the foundation of adaptive immune responses.
Xinyue Dai, Zhaoshuo Wang, Miao Fan, Huifang Liu, Xinjian Yang, Xueyi Wang, Xiaohan Zhou, Yunlu Dai, Jinchao Zhang, Zhenhua Li   +9 more
doaj   +1 more source