Results 61 to 70 of about 1,588,316 (303)

A critical systematic review of extracellular vesicle clinical trials

Journal of Extracellular Vesicles
This systematic review examines the landscape of extracellular vesicle (EV)‐related clinical trials to elucidate the field's trends in clinical applications and EV‐related methodologies, with an additional focus on the acknowledgement of EV ...
Rachel R. Mizenko, Madison Feaver, B. Bozkurt, Neona M. Lowe, Bryan B. Nguyen, Kuan-Wei Huang, Ai-Jun Wang, Randy P. Carney   +7 more
semanticscholar   +1 more source

Extracellular Vesicle-Mediated Transfer of LncRNA IGFL2-AS1 Confers Sunitinib Resistance in Renal Cell Carcinoma

Cancer Research, 2022
Extracellular vesicle-packaged IGFL2-AS1 promotes sunitinib resistance by regulating TP53INP2-triggered autophagy, implicating this lncRNA as a potential therapeutic target in renal cell carcinoma.
Yihui Pan, Xuan-Xuan Lu, Guan-nan Shu, Junjie Cen, Jun Lu, Mi Zhou, Kang-Bo Huang, Jiaqi Dong, Jia-Ying Li, Haishan Lin, Hong-De Song, Quan-Hui Xu, Hui Han, Zhen-Hua Chen, W. Chen, Junhang Luo, Jin-Huan Wei, Jia-Xing Zhang   +17 more
semanticscholar   +1 more source

Extracellular Vesicles and Metastasis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
Secretion of cell contents through extracellular vesicles (EVs), such as exosomes and microvesicles, is a fundamental cell behavior. Compared with their normal counterparts, cancer cells are different in the amount and composition of EVs they secrete as a result of intrinsic and extrinsic (microenvironmental) alterations.
openaire   +3 more sources

Extracellular Vesicles in Phylogeny

International Journal of Molecular Sciences, 2023
Extracellular vesicles (EVs) are cell-derived lipid vesicles in a size range of 20–1000 nm; often, these are classified as smaller and larger EVs in the literature or also commonly called small EVs (“exosomes”) and medium/large EVs (“microvesicles”) [...]
openaire   +2 more sources

Extracellular Vesicles as Regulators of the Extracellular Matrix

Bioengineering, 2023
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which ...
Neil J. Patel, Anisa Ashraf, Eun Ji Chung   +2 more
openaire   +3 more sources

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Nature Medicine
Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
M. Chatterjee, S. Özdemir, Christian G. Fritz, W. Möbius, L. Kleineidam, E. Mandelkow, J. Biernat, Cem Doğdu, O. Peters, N. Cosma, Xiao Wang, Luisa-Sophia Schneider, J. Priller, E. Spruth, A. Kühn, P. Krause, T. Klockgether, I. Vogt, O. Kimmich, A. Spottke, Daniel C. Hoffmann, K. Fliessbach, Carolin Miklitz, C. McCormick, P. Weydt, Björn H. Falkenburger, Moritz D. Brandt, René Guenther, E. Dinter, Jens Wiltfang, Niels Hansen, M. Bähr, Inga Zerr, A. Flöel, Peter J. Nestor, E. Düzel, W. Glanz, E. Incesoy, Katharina Bürger, D. Janowitz, R. Perneczky, B. Rauchmann, Franziska Hopfner, O. Wagemann, J. Levin, S. Teipel, I. Kilimann, D. Goerss, J. Prudlo, T. Gasser, Kathrin Brockmann, D. Mengel, M. Zimmermann, M. Synofzik, C. Wilke, J. Selma-González, J. Turon-Sans, M. Santos-Santos, D. Alcolea, S. Rubio-Guerra, J. Fortea, Á. Carbayo, A. Lleó, Ricardo Rojas-García, I. Illán-Gala, M. Wagner, I. Frommann, S. Roeske, L. Bertram, M. Heneka, F. Brosseron, A. Ramírez, Matthias Schmid, Rudi Beschorner, A. Halle, Jochen Herms, Manuela Neumann, N. Barthélemy, R. Bateman, P. Rizzu, P. Heutink, O. Dols-Icardo, Günther U. Höglinger, A. Hermann, A. Schneider   +84 more
semanticscholar   +1 more source

The power of imaging to understand extracellular vesicle biology in vivo

Nature Methods, 2021
Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every cell type. EVs have diverse biological activities, ranging from roles in development and homeostasis to cancer progression, which has spurred the development ...
F. Verweij, Leonora Balaj, C. Boulanger, D. R. Carter, E. Compeer, G. D’angelo, S. el Andaloussi, J. Goetz, J. C. Gross, V. Hyenne, Eva-Maria Krämer-Albers, C. Lai, X. Loyer, A. Marki, S. Momma, E. N. Nolte-'t Hoen, D. Pegtel, H. Peinado, G. Raposo, K. Rilla, H. Tahara, C. Théry, M. V. van Royen, R. Vandenbroucke, A. M. Wehman, Kenneth W. Witwer, Zhi-Wei Wu, R. Wubbolts, G. van Niel   +28 more
semanticscholar   +1 more source

Immunogenicity of Extracellular Vesicles

Advanced Materials
Abstract Extracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (beyond the apparent lack of immunotoxicity) to advance clinical ...
Yutian Xia, Jianzhong Zhang, Gang Liu, Joy Wolfram   +3 more
openaire   +4 more sources

Extracellular Vesicles in Angiogenesis

Circulation Research, 2017
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important players in cell-to-cell communication in normal physiology and pathological conditions. EVs encapsulate and convey various bioactive molecules that are further transmitted to neighboring or more distant cells ...
Todorova, Dilyana, Simoncini, Stéphanie, Lacroix, Romaric, Sabatier, Florence, Dignat-George, Françoise   +4 more
openaire   +2 more sources

Extracellular Vesicles in Phytopathogenic Fungi

Extracellular Vesicles and Circulating Nucleic Acids, 2023
Extracellular vesicles (EVs) are nano-sized, lipid compartments that mediate the intercellular transport of lipids, proteins, nucleic acids and metabolites. During infectious diseases, EVs released by host cells promote immune responses, while those released by pathogens attempt to subvert host immunity.
Rutter, Brian D., Innes, Roger W.
openaire   +2 more sources