Results 81 to 90 of about 1,588,316 (303)

Exomap1 mouse: A transgenic model for in vivo studies of exosome biology

Extracellular Vesicle, 2023
Exosomes are small extracellular vesicles (sEVs) of ∼30–150 nm in diameter that are enriched in exosome marker proteins and play important roles in health and disease.
Francis K. Fordjour, Sarah Abuelreich, Xiaoman Hong, Emeli Chatterjee, Valeria Lallai, Martin Ng, Andras Saftics, Fengyan Deng, Natacha Carnel-Amar, Hiroaki Wakimoto, Kazuhide Shimizu, Malia Bautista, Tuan Anh Phu, Ngan K. Vu, Paige C. Geiger, Robert L. Raffai, Christie D. Fowler, Saumya Das, Lane K. Christenson, Tijana Jovanovic-Talisman, Stephen J. Gould   +20 more
doaj   +1 more source

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

Communications Biology, 2021
Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical models.
S. Jang, Kyriakos D. Economides, R. Moniz, Ling-Sia Chang, Nuruddeen D. Lewis, C. McCoy, Tong Zi, Kelvin Zhang, Rane A. Harrison, Joanne Lim, Joyoti Dey, Marc Grenley, K. Kirwin, N. Ross, R. Bourdeau, Agata Villiger-Oberbek, S. Estes, Ke Xu, J. Sanchez-Salazar, Kevin Dooley, W. Dahlberg, Douglas E. Williams, S. Sathyanarayanan   +22 more
semanticscholar   +1 more source

Extracellular Vesicles of Neutrophils [PDF]

Immune Network, 2018
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be categorized into 2 subtypes according to the mechanism of generation.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles

Journal of Extracellular Biology
5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair. However, 5‐FU is
Shimian Qu, Hannah M. Nelson, Xiao Liu, Yu Wang, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton   +13 more
doaj   +1 more source

Engineered IL-15/IL-15Rα-expressing cellular vesicles promote T cell anti-tumor immunity

Extracellular Vesicle, 2023
Interleukin 15 (IL-15) is a pivotal immune cytokine that responses to cancer stress signals and maintains tissue-resident memory T (TRM) cells. It is therefore considered as a potent therapeutic immunomodulator agonist cancer. However, in addition to the
Wenli Fang, Liyan Li, Zhongda Lin, Yuli Zhang, Zhangyan Jing, Yuan Li, Zhirang Zhang, Linlin Hou, Xin Liang, Xingding Zhang, Xudong Zhang   +10 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cholesteryl esters and high protein-to-lipid ratios distinguish non-vesicular extracellular particles from extracellular vesicles

Cell Communication and Signaling
Background Mechanisms governing non-vesicular extracellular particle (NVEP) biogenesis and compositional diversity remain incompletely characterized. Method This study integrates multiparametric profiling to define NVEPs.
Sayam Ghosal, Rita Leporati, Árpád Varga, Petra Susanszki, Nóra Fekete, Tamás László, Tünde Bárkai, Fülöp Károly Grébecz, Delaram Khamari, Tárek Zoltán Magyar, Marcus Hoering, Krisztina V Vukman, Bernadett R Bodnár, Brachyahu M Kestecher, Mohamed A Fattah, Csaba Bödör, József Maléth, Gerhard Liebisch, Evelyn Orsó, Edit I Buzas, Xabier Osteikoetxea   +20 more
doaj   +1 more source

Development of extracellular vesicle-based medicinal products: a position paper of the group "Extracellular Vesicle translatiOn to clinicaL perspectiVEs - EVOLVE France".

Advanced Drug Delivery Reviews, 2021
Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate quality, safety, and efficacy, as required for any medicinal ...
Amanda K. A. Silva, M. Morille, Max Piffoux, Surendar Arumugam, Phlippe Mauduit, J. Larghero, A. Bianchi, K. Aubertin, O. Blanc-Brude, D. Noël, É. Velot, C. Ravel, C. Elie-Caille, A. Sebbagh, C. Boulanger, C. Wilhelm, G. Rahmi, I. Raymond-Letron, Kondareddy Cherukula, T. Montier, C. Martinaud, J. Bach, O. Favre-Bulle, J. Spadavecchia, C. Jorgensen, P. Menasché, C. Aussel, J. Chopineau, Mathilde Mosser, Matti Ullah, Nicolas Sailliet, N. Luciani, N. Mathieu, P. Rautou, S. Brouard, W. Boireau, S. Jauliac, M. Dedier, J. Trouvin, F. Gazeau, M. Trouillas, J. Peltzer, A. Monsel, S. Banzet   +43 more
semanticscholar   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source