Results 101 to 110 of about 1,588,316 (303)

A call for Rigor and standardization in plant extracellular vesicle research

Journal of Extracellular Vesicles, 2021
All living cells, including archaea, bacteria, and eukaryotes, release nano-sized lipid-bilayer membrane vesicles known as extracellular vesicles (EVs) for reasons ranging from disposal of toxic materials to intercellular communication (Margolis ...
M. Pinedo, L. de la Canal, C. de Marcos Lousa   +2 more
semanticscholar   +1 more source

Understanding extracellular vesicles [PDF]

PROTEOMICS, 2021
David W. Greening, Richard J. Simpson
openaire   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Protein quantification of extracellular vesicle preparation fractions from differential centrifugation and size exclusion chromatography purification.

, 2019
Fractions produced from either differential centrifugation or size exclusion chromatography methods (excretory-secretory protein, whole lysed extracellular vesicle, soluble extracellular vesicle protein and insoluble extracellular vesicle protein) were ...
Peter M. Brophy (162777), Russell M. Morphew (162753), Chelsea N. Davis (6407891), John J. Tomes (6407894), Helen Phillips (3347261), Martin T. Swain (3290154), Toby J. Wilkinson (2016139)   +6 more
core   +1 more source

Exosomal delivery of IL-10: Biodistribution, pharmacokinetics, and preterm birth prevention strategies

Extracellular Vesicle
This study investigates the potential of extracellular vesicles (EVs) loaded with interleukin-10 (IL-10) to reduce infection-induced preterm birth (PTB).
Brinley Harrington, Tilu Jain Thomas, Madhuri Tatiparthy, Awanit Kumar, Lauren Richardson, Ramkumar Menon, Ananth Kumar Kammala   +6 more
doaj   +1 more source

Immunotherapeutic Potential of Extracellular Vesicles [PDF]

Frontiers in Immunology, 2014
Extracellular vesicle or EV is a term that encompasses all classes of secreted lipid membrane vesicles. Despite being scientific novelties, EVs are gaining importance as a mediator of important physiological and pathological intercellular activities possibly through the transfer of their cargo of protein and RNA between cells.
Bin eZhang, Yijun eYin, Ruenn Chai eLai, Sai Kiang eLim, Sai Kiang eLim   +4 more
openaire   +3 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Characterizing the Fate of Anti‐CS1 Nanobody Displaying Extracellular Vesicles in Multiple Myeloma

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are promising delivery vehicles capable of transporting therapeutic agents across biological barriers. However, native EVs primarily accumulate in liver, spleen and lungs, limiting targeted delivery to disease sites.
Michiel De Coster, Lukas Hyka, Sophie De Cock, Sofie Meeussen, Zuowei Wang, Chenggong Tu, Sophie Hernot, Nick Devoogdt, Guido David, Kim De Veirman, Karin Vanderkerken, Eline Menu, Pascale Zimmermann, Elke De Bruyne   +13 more
doaj   +1 more source

Unveiling exosomal biomarkers in neurodegenerative diseases: LC-MS-based profiling

Extracellular Vesicle
Exosomes, small extracellular vesicles secreted by various cell types, play a critical role in intercellular communication and are increasingly recognized as key players in the progression of neurodegenerative diseases (NDs).
Yue Bi, Liang Wang, Chunyan Li, Zhiying Shan, Lanrong Bi   +4 more
doaj   +1 more source

Reproducibility of extracellular vesicle research.

European Journal of Cell Biology, 2022
Cells release membrane-delimited particles into the environment. These particles are called "extracellular vesicles" (EVs), and EVs are present in fluids contacting cells, including body fluids and conditioned culture media.
R. Nieuwland, P. Siljander, J. Falcón-Perez, Kenneth W. Witwer   +3 more
semanticscholar   +1 more source