Results 91 to 100 of about 1,588,316 (303)

Identifying protein signatures in vesicles associated with treatment response in pulmonary sarcoidosis

Extracellular Vesicle
Approximately 30% of patients with sarcoidosis require immunosuppressive therapy to relieve symptoms or prevent organ damage. Prednisone and methotrexate (MTX) are the most commonly used therapies; however, treatment response varies considerably between ...
Raisa Kraaijvanger, Montse Janssen Bonás, Ioanna Paspali, Freek G. Bouwman, Claudia Roodenburg, Jelle R. Miedema, Dominique P.V. de Kleijn, Jan C. Grutters, Marcel Veltkamp, Coline H.M. van Moorsel   +9 more
doaj   +1 more source

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

Journal of Extracellular Vesicles, 2021
The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental signalling gateway by bridging intra‐ and extracellular signalling networks, dictates EVs’ capacity to communicate and interact with their environment, and is a source of ...
A. Rai, Hao-Yun Fang, B. Claridge, R. Simpson, D. Greening   +4 more
semanticscholar   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Extracellular Vesicle-Based Therapeutics in Neurological Disorders

, 2022
Neurological diseases remain some of the major causes of death and disability in the world. Few types of drugs and insufficient delivery across the blood–brain barrier limit the treatment of neurological disorders.
Weiwei Shen, Yiwen Yuan, Shen, Weiwei, Dong, Qiang, Wenqing Xu, Sun, Jian, Jian Sun, Xu, Wenqing, Yuan, Yiwen, Tongyao You, Qiang Dong, Cui, Mei, Mei Cui, You, Tongyao   +13 more
core   +1 more source

Cell line specific Contactin-2+ extracellular vesicles vs circulating cell-free microRNA: A proof of concept examination of diagnostic accuracy as the standard to evaluate EV/small EV biomarkers

Extracellular Vesicle
A combination of extracellular vesicle precipitation followed by immunoaffinity based on the target cell/organ enhances biomarker performance (e.g. positive predictive value) compared to the same panel of circulating cell-free micro RNAs in our test ...
Sarah T. Mehl, Lierni Ugartemendia, Nikolay A. Bliznyuk, Baharan Fekry, Fatima Dakroub, Firas Kobeissy, Stefania Mondello, Michael D. Weiss, Laura Goetzl   +8 more
doaj   +1 more source

Clinical Translation of Extracellular Vesicles

Advanced Healthcare Materials, 2023
AbstractExtracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent attraction as natural materials due to their bioactive surfaces, internal cargo, and role in intercellular communication. EVs contain various biomolecules, including surface and cytoplasmic proteins; and nucleic acids that are often representative of the ...
Aayushi Ghodasara, Aun Raza, Joy Wolfram, Carlos Salomon, Amirali Popat   +4 more
openaire   +4 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level

, 2022
The discovery and development of extracellular vesicles in tissue engineering have shown great potential for tissue regenerative therapies. However, their vesicle nature requires dosage-dependent administration and efficient interactions with recipient ...
Tang, Yaohui, Chen, Ao, Tian, Hengli, Yang, Guo-Yuan, Zhang, Zhijun, Cui, Wenguo, Yang, Nana   +6 more
core  

A Syndecan‐Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies

Journal of Extracellular Biology
Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited.
Lukas Hyka, Sofie Meeussen, Rania Ghossoub, Michiel De Coster, Elke De Bruyne, Guido David, Patrick Chames, Pascale Zimmermann   +7 more
doaj   +1 more source

Exofection by exosomes: A transient functional cargo transfer

Extracellular Vesicle
Exosomes have emerged as key mediators of inter-cellular communication, transporting a diverse array of cargos that can reflect the current biological state of the cell.
Ramkumar Menon, Madhuri Tatiparthy, Jessica Selim, Isidore Mushimiyimana, Brinley Harrington, Awanit Kumar, Lauren Richardson, Emmanuel Amabebe, Ananth Kumar Kammala   +8 more
doaj   +1 more source