Results 111 to 120 of about 1,588,316 (303)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury

Extracellular Vesicle
Radiation-induced intestinal injury (RIII) is a prevalent complication of radiotherapy for abdominal and pelvic tumors, characterized by acute and chronic damage to intestinal tissues.
Tong An, Daqin Li, Ning Wang, Feifei Ma, Tuo Li, Ningning He, Huijuan Song, Qiang Liu   +7 more
doaj   +1 more source

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Frontiers in Cell and Developmental Biology, 2021
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and commercial limitations.
B. Claridge, Jonathan Lozano, Qi Hui Poh, D. Greening   +3 more
semanticscholar   +1 more source

Therapeutic Potential of Extracellular Vesicles [PDF]

Frontiers in Immunology, 2014
Extracellular vesicles (EV) have emerged as important mediators of intercellular communication. By their origin, we can find vesicles derived from plasma membrane such as microvesicles, ectosomes, and membrane particles or exosomes, which originate in the endosomal membrane compartment.
Merino, Ana, Hoogduijn, Martin Johannes, Borràs i Serres, Francesc Enric, Franquesa, Marcella   +3 more
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Supplementary Data from Highly Sensitive EGFRvIII Detection in Circulating Extracellular Vesicle RNA of Glioma Patients

, 2022
Supplementary Data from Highly Sensitive EGFRvIII Detection in Circulating Extracellular Vesicle RNA of Glioma ...
Yulia B. Rosenfeld (15042737), Bob S. Carter (15042746), Koushik Muralidharan (15042725), Sirena K. Khanna (15042740), Sarah Falotico (15042731), Syeda Maheen Batool (15042722), Tiffany Hsia (15042728), Leonora Balaj (15042743), Austin S. Gamblin (15042734)   +8 more
core   +1 more source

MicroRNAs won the Nobel Prize. Now, can extracellular vesicles help them become drugs?

Extracellular Vesicle
The 2024 Nobel Prize recognized microRNAs (miRNAs) as transformative regulators of gene expression. However, their clinical potential has been constrained by instability and delivery challenges. Extracellular vesicles (EVs), as natural carriers of miRNAs,
Vanessa YiRan Li, Nicole Rosas, Sharon Fleischer, Gordana Vunjak-Novakovic, Ke Cheng   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Aptamer-guided extracellular vesicle theranostics in oncology

, 2020
Aptamer-guided extracellular vesicle theranostics in ...
Y Ma (7409624), PHL Tran (14446029), Y Li (4701352), Q Chen (7742036), M Sun (7750958), G Jiang (6099806), D Xiang (6699812), K Chen (7748387), TTD Tran (14446026), W Yin (7709840), Y Hou (11742365), Wei Duan (13099662), A Duan (13447032), Y Zhu (6338063), TNG Nguyen (14460195), Y Zhang (5998940), Lingxue Kong (13081401)   +16 more
core  

Protein profiles of extracellular vesicle fractions from differential centrifugation and size exclusion chromatography purification.

, 2019
Biological triplicate protein profiles as observed by one dimensional SDS-PAGE electrophoresis of excretory-secretory protein (10 μg protein), whole lysed extracellular vesicle (10 μg protein), soluble extracellular vesicle protein (20 μg protein) and ...
Peter M. Brophy (162777), Russell M. Morphew (162753), Chelsea N. Davis (6407891), John J. Tomes (6407894), Helen Phillips (3347261), Martin T. Swain (3290154), Toby J. Wilkinson (2016139)   +6 more
core   +1 more source