Results 131 to 140 of about 1,588,316 (303)

Characterization of plasma-derived small extracellular vesicle miRNA and protein cargo in hereditary angioedema

Extracellular Vesicle
Hereditary angioedema (HAE) is an inherited disorder causing attacks of subcutaneous tissue or mucosa swelling. The disease burden and attack frequencies vary significantly among patients.
Linda Hofmann, Robin Lochbaum, Lutz Schütt, Ralph Röth, Stefanie Schmitteckert, Barbara Wollenberg, Thomas K. Hoffmann, Cornelia Brunner, Jens Greve, Janina Hahn, Marie-Nicole Theodoraki   +10 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Quantitative flow cytometry (qFCM) enables end-to-end optimization of cross-platform extracellular vesicle studies.

, 2023
Scripts and metadata to support manuscript:  Quantitative flow cytometry (qFCM) enables end-to-end optimization of cross-platform extracellular vesicle studies. 
Joshua Welsh (5926553), Jennifer Jones (13511816), Sean Cook (13511750), Vera Tang (6900758)   +3 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Hydrophobic effects in membrane sensing peptides for small extracellular vesicle isolation and analysis

, 2021
Hydrophobic effects in membrane sensing peptides for small extracellular vesicle isolation and ...
A Strada, A Gori, G Bergamaschi, A Musicò, M Cretich, R Vago, R Frigerio   +6 more
core  

Figure S6 from Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

, 2021
Chemotherapy upregulates small extracellular vesicle-associated PTX3 protein expression, which has no effect on cell migration and invasion in vitro or primary tumor growth in vivo.
Carson A. Wills (14946706), Xiaoming Liu (47653), Jeffrey Sundstrom (14946712), Longgui Chen (14946709), Yuanjun Zhao (8995022), Hong-Gang Wang (14946715), Christopher M. Dower (14929020)   +6 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Figure S7 from Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

, 2021
Inhibition of small extracellular vesicle uptake and secretion does not affect breast cancer migration in vitro or primary tumor growth in vivo.
Carson A. Wills (14946706), Xiaoming Liu (47653), Jeffrey Sundstrom (14946712), Longgui Chen (14946709), Yuanjun Zhao (8995022), Hong-Gang Wang (14946715), Christopher M. Dower (14929020)   +6 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source