Precise nanosizing with high dynamic range holography [PDF]
, 2020 Optical sensing is one of the key-enablers of modern diagnostics. Especially label-free imaging modalities hold great promise as they eliminate labeling procedures prior to analysis. However, scattering signals of nanometric particles scale with their volume-square.
arxiv +1 more source
MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. [PDF]
, 2017 Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to human and is hypothesized to be relevant to the cause of human disease.
Davis, Graeme W +5 more
core +2 more sources
Inhalable exosomes outperform liposomes as mRNA and protein drug carriers to the lung
Extracellular Vesicle, 2022 Respiratory diseases are among the leading causes of morbidity and mortality worldwide, coupled with the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Kristen D. Popowski +12 more
doaj
Towards defining reference materials for extracellular vesicle size, concentration, refractive index and epitope abundance [PDF]
, 2020 Accurate characterization of extracellular vesicles (EVs) is critical to explore their diagnostic and therapeutic applications. As the EV research field has developed, so too have the techniques used to characterize them. The development of reference materials is required for the standardization of these techniques.
arxiv +1 more source
Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses. [PDF]
, 2019 Extracellular RNAs (exRNAs) can be released by numerous cell types in vitro, are often protected within vesicles, and can modify recipient cell function. To determine how the composition and cellular sources of exRNAs and the extracellular vesicles (EVs)
Ansel, K Mark +6 more
core +1 more source
Extracellular Vesicle, 2022 Dysregulated Myc signaling is a key oncogenic pathway in glioblastoma multiforme (GBM). Yet, effective therapeutic targeting of Myc continues to be challenging.
Amanda R. Haltom +16 more
doaj
Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces [PDF]
arXiv, 2021 Eukaryotic cells adhere to extracellular matrix during the normal development of the organism, forming static adhesion as well as during cell motility. We study this process by considering a simplified coarse-grained model of a vesicle that has uniform adhesion energy with a flat substrate, mobile curved membrane proteins and active forces.
arxiv
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]
, 2011 Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun +3 more
core +2 more sources
Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways
Extracellular Vesicle, 2023 Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo released by cells and postulated to mediate functions such as intercellular communications. Recent studies have shown that long non-coding RNAs (lncRNAs) or their
Michail Spanos +5 more
doaj
Extracellular vesicle-induced differentiation of neural stem progenitor cells [PDF]
, 2019 Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may differentiate toward either neuronal or glial phenotypes or both.
Biagioni, S. +5 more
core +1 more source