Scalable trapping of single nanosized extracellular vesicles using plasmonics [PDF]
Heterogeneous nanoscale particles released by cells known as extracellular vesicles (EVs) are actively investigated for early disease detection1, monitoring2, and advanced therapeutics3. Due to their extremely small size, the stable trapping of nano-sized EVs using diffraction-limited optical tweezers4 has been met with challenges.
arxiv +1 more source
Extracellular Vesicles in Angiogenesis
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important players in cell-to-cell communication in normal physiology and pathological conditions. EVs encapsulate and convey various bioactive molecules that are further transmitted to neighboring or more distant cells ...
Françoise Dignat-George+4 more
openaire +3 more sources
Extracellular Vesicles in Phylogeny
Extracellular vesicles (EVs) are cell-derived lipid vesicles in a size range of 20–1000 nm; often, these are classified as smaller and larger EVs in the literature or also commonly called small EVs (“exosomes”) and medium/large EVs (“microvesicles”) [...]
openaire +2 more sources
Extracellular Vesicles in Hepatobiliary Malignancies [PDF]
Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile duct epithelial cells) or hepatoblasts (embryonic ...
Maria J. Perugorria+11 more
openaire +5 more sources
Extracellular Vesicles in Veterinary Medicine
Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles involved in many physiological and pathological processes not only in humans but also in all the organisms of the eukaryotic and prokaryotic kingdoms. EV shedding constitutes a fundamental universal mechanism of intra-kingdom and inter-kingdom intercellular communication.
Moccia, V+5 more
openaire +4 more sources
Plasmonic dielectric antennas for hybrid optical nanotweezing and optothermoelectric manipulation of single nanosized extracellular vesicles [PDF]
We present an experimental demonstration of near-field optical trapping and dynamic manipulation of a single extracellular vesicle using a plasmonic dielectric nanoantenna that supports an optical anapole state. The optical anapole is a non-radiating optical state generated by the destructive interference between electric and toroidal dipoles in the ...
arxiv
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh+5 more
wiley +1 more source
Extracellular Vesicles of Neutrophils [PDF]
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be categorized into 2 subtypes according to the mechanism of generation.
openaire +3 more sources
Inhalable exosomes outperform liposomes as mRNA and protein drug carriers to the lung
Respiratory diseases are among the leading causes of morbidity and mortality worldwide, coupled with the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Kristen D. Popowski+12 more
doaj
Size stability and self-agglomeration of erythrocyte-derived membrane nanovesicles versus physiological extracellular vesicles [PDF]
Extracellular vesicles (EVs) and plasma membrane-derived exosome-mimetic nanovesicles demonstrate significant potential for drug delivery. Latter synthetic provides higher throughput over physiological EVs. However they face size-stability and self-agglomeration challenges in physiological solutions to be properly characterized and addressed.
arxiv