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An Improved Method to Enrich Large Extracellular Vesicles Derived from Giardia intestinalis through Differential Centrifugation

open access: yesLife, 2023
Giardia intestinalis is a flagellated unicellular protozoan that colonizes the small intestine, causing the diarrheal disease called giardiasis. The production of extracellular vesicles (EVs) by G. intestinalis and the role of these EVs in the parasite’s
Abel Sana   +5 more
doaj   +1 more source

Bacterial subversion of NLR-mediated immune responses

open access: yesFrontiers in Immunology, 2022
Members of the mammalian Nod-like receptor (NLR) protein family are important intracellular sensors for bacteria. Bacteria have evolved under the pressure of detection by host immune sensing systems, leading to adaptive subversion strategies to dampen ...
Ioannis Kienes   +7 more
doaj   +1 more source

Extracellular Vesicles in neural cell interaction and CNS homeostasis

open access: yesFASEB BioAdvances, 2021
Central nervous system (CNS) homeostasis critically depends on the interaction between neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile messengers in CNS cell communication.
Andrea Schnatz   +3 more
doaj   +1 more source

Protein Biocargo and Anti-Inflammatory Effect of Tomato Fruit-Derived Nanovesicles Separated by Density Gradient Ultracentrifugation and Loaded with Curcumin

open access: yesPharmaceutics, 2023
Plant-derived nanovesicles (PDNVs) have become attractive alternatives to mammalian cell-derived extracellular vesicles (EVs) both as therapeutic approaches and drug-delivery vehicles.
Ramila Mammadova   +11 more
doaj   +1 more source

Bacteroides fragilis outer membrane vesicles preferentially activate innate immune receptors compared to their parent bacteria

open access: yesFrontiers in Immunology, 2022
The release of bacterial membrane vesicles (BMVs) has become recognized as a key mechanism used by both pathogenic and commensal bacteria to activate innate immune responses in the host and mediate immunity.
William J. Gilmore   +13 more
doaj   +1 more source

Coarse-Grained Molecular Simulation of Extracellular Vesicles Squeezing for Drug Loading [PDF]

open access: yeshttps://pubs.rsc.org/en/content/articlelanding/2023/cp/d3cp00387f, 2022
In recent years, extracellular vesicles such have become promising carriers as the next-generation drug delivery platforms. Effective loading of exogenous cargos without compromising the extracellular vesicle membrane is a major challenge. Rapid squeezing through nanofluidic channels is a widely used approach to load exogenous cargoes into the EV ...
arxiv   +1 more source

The relationship between chronic immune response and neurodegenerative damage in long COVID-19

open access: yesFrontiers in Immunology, 2022
In the past two years, the world has faced the pandemic caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2), which by August of 2022 has infected around 619 million people and caused the death of 6.55 million individuals globally ...
José Pedro Elizalde-Díaz   +3 more
doaj   +1 more source

Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy

open access: yesJournal of Extracellular Vesicles, 2021
Gram‐positive bacteria ubiquitously produce membrane vesicles (MVs), and although they contribute to biological functions, our knowledge regarding their composition and immunogenicity remains limited.
Natalie J. Bitto   +9 more
doaj   +1 more source

Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk

open access: yesScientific Reports, 2021
HIV and type 2 diabetes (T2D) are both associated with gut microbiota alterations, low-grade endotoxemia and increased cardiovascular risk. We investigated the potential role of plasma extracellular vesicles (EVs) in relation to these processes.
Beate Vestad   +12 more
doaj   +1 more source

Identification of Tomato Infecting Viruses That Co-Isolate with Nanovesicles Using a Combined Proteomics and Electron-Microscopic Approach

open access: yesNanomaterials, 2021
Plant-derived nanovesicles (NVs) have attracted interest due to their anti-inflammatory, anticancer and antioxidative properties and their efficient uptake by human intestinal epithelial cells.
Ramila Mammadova   +11 more
doaj   +1 more source

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