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Extracellular Vesicles and Nanoparticles: Emerging Complexities
Trends in Cell Biology, 2023 The study of extracellular vesicles and nanoparticles is rapidly expanding as recent discoveries have revealed a much greater complexity and diversity than was appreciated just a few years ago.
D. K. Jeppesen +3 more
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The Role of Extracellular Vesicles in Cancer
Cell, 2023 Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells and recent studies have identified EVs as key mediators of cell-cell communication via ...
R. Kalluri, Kathleen M. McAndrews
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GENETICSCells, pathogens, and other systems release extracellular vesicles (EVs). The particles promote intercellular communication and contain proteins, lipids, RNA and DNA. Initially considered to be cellular waste in the twentieth century, EVs were becoming recognized for their function in biological communication and control.
Mariana Ottaiano, Gonçalves +5 more
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A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication
Cell Communication and Signaling, 2023 Extracellular vesicles (EVs) are small, membrane-bound structures that are released from cells into the surrounding environment. These structures can be categorized as exosomes, microvesicles, or apoptotic vesicles, and they play an essential role in ...
Ya-Juan Liu, Cheng Wang
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Extracellular vesicles: a rising star for therapeutics and drug delivery
Journal of Nanobiotechnology, 2023 Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells.
S. Du +8 more
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Metalloproteinases in extracellular vesicles
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communications in local and distant microenvironments under patho/physiological conditions. EVs contain bioactive materials such as proteins, RNA transcripts, microRNAs and even DNAs, and recent work on their protein profiles has revealed the existence of metalloproteinases
Masayuki, Shimoda, Rama, Khokha
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Cells, 2019 The use of extracellular vesicles, specifically exosomes, as carriers of biomarkers in extracellular spaces has been well demonstrated. Despite their promising potential, the use of exosomes in the clinical setting is restricted due to the lack of ...
Laura M Doyle, Michael Zhuo Wang
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Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
Molecular Therapy, 2023 Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic applications in various diseases. These natural nanoparticles benefit from favorable safety profiles and unique biodistribution capabilities, rendering them ...
J. Rädler +3 more
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Extracellular vesicle analysis
Nature Reviews Methods Primers, 2023 Cells release small, phospholipid membrane-enclosed particles, collectively referred to as extracellular vesicles (EVs), into their surroundings to enable intercellular communication. EVs have numerous functions in physiological and pathophysiological processes and show considerable promise for diagnostic and therapeutic applications. Technologies have
An Hendrix +8 more
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Comprehensive Isolation of Extracellular Vesicles and Nanoparticles
Nature Protocols, 2023 There is an increasing appreciation for the heterogeneous nature of extracellular vesicles (EVs). In addition, two nonvesicular extracellular nanoparticles (NVEPs), exomeres and supermeres, have been discovered recently that are enriched in many cargo ...
Qin Zhang +4 more
semanticscholar +1 more source