Results 21 to 30 of about 1,214,978 (300)

Bacterial subversion of NLR-mediated immune responses

Frontiers in Immunology, 2022
Members of the mammalian Nod-like receptor (NLR) protein family are important intracellular sensors for bacteria. Bacteria have evolved under the pressure of detection by host immune sensing systems, leading to adaptive subversion strategies to dampen ...
Ioannis Kienes, Ella L. Johnston, Ella L. Johnston, Natalie J. Bitto, Natalie J. Bitto, Maria Kaparakis-Liaskos, Maria Kaparakis-Liaskos, Thomas A. Kufer   +7 more
doaj   +1 more source

Extracellular Vesicles in Phylogeny [PDF]

, 2023
Extracellular vesicles (EVs) are cell-derived lipid vesicles in a size range of 20–1000 nm; often, these are classified as smaller and larger EVs in the literature or also commonly called small EVs (“exosomes”) and medium/large EVs (“microvesicles”) [...
Lange, S.
core   +1 more source

The roles of extracellular vesicles in the immune system

Nature reviews. Immunology, 2022
Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their ...
E. Buzás
semanticscholar   +1 more source

Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity [PDF]

, 2020
Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular VesiclesGlycyl-tRNA synthetase 1 (GARS1), a cytosolic enzyme secreted from macrophages, promotes apoptosis in cancer cells ...
Won Suk Yang, Sehyun Chae, Chihong Song, Kim, Byung Gyu, Yong Song Gho, Gho, Yong Song, Hyun, Jae Kyung, Goughnour, Peter C, Yang, Won Suk, Cho, Seongmin, Song, Chihong, Daehee Hwang, Jung, Hyun Suk, Park, Min Chul, Kim, Sunghoon, Jun, Sangmi, Chae, Sehyun, Lee, Ji-Hyun, Hwang, Daehee, Min Chul Park, Ji‐Hyun Lee, Goughnour, Peter C., Lee, Ji‐Hyun, Jae Kyung Hyun, Seongmin Cho, Hyun Suk Jung, Sunghoon Kim, Sangmi Jun, Kim, Sang Bum, Peter C. Goughnour, Sang Bum Kim, Byung Gyu Kim   +31 more
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Bacteroides fragilis outer membrane vesicles preferentially activate innate immune receptors compared to their parent bacteria

Frontiers in Immunology, 2022
The release of bacterial membrane vesicles (BMVs) has become recognized as a key mechanism used by both pathogenic and commensal bacteria to activate innate immune responses in the host and mediate immunity.
William J. Gilmore, William J. Gilmore, Ella L. Johnston, Ella L. Johnston, Natalie J. Bitto, Natalie J. Bitto, Lauren Zavan, Lauren Zavan, Neil O'Brien-Simpson, Andrew F. Hill, Andrew F. Hill, Andrew F. Hill, Maria Kaparakis-Liaskos, Maria Kaparakis-Liaskos   +13 more
doaj   +1 more source

Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells

, 2022
Aim: Elevated brain deposits of amyloid beta (Aβ40) contribute to neuropathology and cognitive dysfunction in Alzheimer’s disease (AD). However, the role of the blood-brain barrier (BBB) as an interface for the transfer of Aβ40 from the periphery into ...
Kowalczyk, Jennifer M, Louis, Kelssey D Pierre, Daftari, Manav T, Dykxhoorn, Derek M, Daftari, Manav T., Colbert, Brett M., Toborek, Michal, Kowalczyk, Jennifer M., András, Ibolya E., Dykxhoorn, Derek M., Colbert, Brett M, Torices, Silvia, Pierre Louis, Kelssey D., Osborne, Olivia M, András, Ibolya E, Naranjo, Oandy, Osborne, Olivia M.   +16 more
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Tumor extracellular vesicles and particles dysregulate liver metabolism

Nature, 2023
Remote tumours cause liver dysfunction by releasing extracellular vesicles and particles containing palmitic acid, which induces TNF signalling in Kupffer cells, resulting in inflammation, fatty deposits and metabolic dysregulation, thus both reducing ...
G. Wang, Jianlong Li, L. Bojmar, Haiyan Chen, Zhong Li, G. Tobias, Mengying Hu, E. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, N. Boudreau, Zhanjun Shi, C. Burd, J. Zippin, James C. Lo, G. Pitt, Jonathan M. Hernandez, C. Zambirinis, M. Hollingsworth, P. Grandgenett, Maneesh Jain, S. Batra, D. Dimaio, J. Grem, K. Klute, T. Trippett, M. Egeblad, D. Paul, Jacqueline Bromberg, D. Kelsen, Vinagolu K. Rajasekhar, J. Healey, Irina R Matei, W. Jarnagin, R. Schwartz, Haiying Zhang, D. Lyden   +42 more
semanticscholar   +1 more source

Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication [PDF]

, 2017
In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes.
Puccia, R., Hansen, E.P., Bergese, P., Marcilla, A., Pereira-Chioccola, V., Nejsum, P., Øvstebø, R., Witwer, K., de la Canal, L., Soares, R.P., Schenkman, S., Colli, W., da Silva, L.L.P., Pfaffl, M.W., Criado, M.F., Del Portillo, H., Stensballe, A., Menezes-Neto, A., Olivier, M., Torrecilhas, A.C., Xander, P., Alves, M.J.M., Jaular, L.M., Nolte-T Hoen, E., Fritz, J., Ferreira, K.S., Gho, Y.S., Abdel Baqui, M.M., Riesbeck, K., Wauben, M., Costa, A.O.   +30 more
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Biomanufacturing of Tomato-Derived Nanovesicles

Foods, 2020
Micro- and nano-sized vesicles (MVs and NVs, respectively) from edible plant resources are gaining increasing interest as green, sustainable, and biocompatible materials for the development of next-generation delivery vectors.
Ramesh Bokka, Anna Paulina Ramos, Immacolata Fiume, Mauro Manno, Samuele Raccosta, Lilla Turiák, Simon Sugár, Giorgia Adamo, Tamás Csizmadia, Gabriella Pocsfalvi   +9 more
doaj   +1 more source

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Nature Communications, 2023
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degradation pathways
Wenjing Liang, Shakti Sagar, Rishith Ravindran, Rita H. Najor, Justin M. Quiles, Liguo Chi, Rachel Y. Diao, Benjamin P. Woodall, Leonardo J. Leon, Erika A. Zumaya, J. Duran, D. Cauvi, A. de Maio, Eric D. Adler, Åsa B. Gustafsson   +14 more
semanticscholar   +1 more source