Results 41 to 50 of about 798,647 (298)

Exploring differential gene expression and biomarker potential in systemic lupus erythematosus: a retrospective study [PDF]

PeerJ
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by inflammation and immune-mediated multi-organ system damage, accompanied by clinical manifestations such as fever, hair loss, skin rash, oral ulcers, and joint ...
Jie Xiao, Yuhong Luo, Lina Duan, Xinru Mao, Lingyue Jin, Haifang Wang, Hongxia Wang, Jie Pan, Ying Gong, Haixia Li   +9 more
doaj   +2 more sources

Immunogenicity of Extracellular Vesicles

Advanced Materials
AbstractExtracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (beyond the apparent lack of immunotoxicity) to advance clinical development.
Yutian Xia, Jianzhong Zhang, Gang Liu, Joy Wolfram   +3 more
openaire   +4 more sources

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +1 more source

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Scientific Reports
Traditional investigations of viral infection mechanisms have predominantly relied on two-dimensional (2D) cell culture models, which lack the structural organization and physiological relevance of native tissues.
Yi-Wen Chen, Huan-Jung Chiang, Kuan-Ting Liu, Chun-Wei Kao, Shan-Ren Xie, Chao-Ming Su, Yu-Yin Shih   +6 more
doaj   +1 more source

NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

Frontiers in Immunology
Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic ...
Bo Shi, Caolingzhi Tang, Stephanie F. Rutter, Omar Audi, Dilara C. Ozkocak, Alice M. Trenerry, Daniel S. Simpson, Scott A. Williams, Quan T. Le, Gemma F. Ryan, Ponsuge T. M. Cooray, James E. Vince, Jason M. Mackenzie, Mark D. Hulett, Thanh Kha Phan, Ivan K. H. Poon   +15 more
doaj   +1 more source

Identification of Tomato Infecting Viruses That Co-Isolate with Nanovesicles Using a Combined Proteomics and Electron-Microscopic Approach

Nanomaterials, 2021
Plant-derived nanovesicles (NVs) have attracted interest due to their anti-inflammatory, anticancer and antioxidative properties and their efficient uptake by human intestinal epithelial cells.
Ramila Mammadova, Immacolata Fiume, Ramesh Bokka, Veronika Kralj-Iglič, Darja Božič, Matic Kisovec, Marjetka Podobnik, Apolonija Bedina Zavec, Matej Hočevar, Gabriella Gellén, Gitta Schlosser, Gabriella Pocsfalvi   +11 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Extracellular vesicles from microalgae

, 2021
The invention relates to extracellular vesicles derived from native, photosynthetic, non-fermenting microalgae, to a method of isolating extracellular vesicles from native, photosynthetic, non-fermenting microalgae by growth, centrifugation and ...
Gabriella Pocsfalvi, Nicolas Touzet, Mauro Manno, Antonella Bongiovanni   +3 more
core  

Extracellular Vesicles

, 2022
Extracellular vesicles (EVs) are nanoscale vesicles secreted by cells that mediate horizontal cargo transport from donor to recipient cell, thereby establishing cell-cell communication and signaling.
İşlek, Zeynep, Bozkurt, Batuhan Turhan, Üçışık, Mehmet Hikmet, Şahin, Fikrettin   +3 more
core   +1 more source

Extracellular Vesicles in Angiogenesis

Circulation Research, 2017
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important players in cell-to-cell communication in normal physiology and pathological conditions. EVs encapsulate and convey various bioactive molecules that are further transmitted to neighboring or more distant cells ...
Todorova, Dilyana, Simoncini, Stéphanie, Lacroix, Romaric, Sabatier, Florence, Dignat-George, Françoise   +4 more
openaire   +2 more sources