Results 41 to 50 of about 1,214,978 (300)

Extracellular Vesicles: New Classification and Tumor Immunosuppression

Biology, 2023
Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are exosomes, microvesicles, and apoptotic bodies.
M. Sheta, E. A. Taha, Yanyin Lu, T. Eguchi   +3 more
semanticscholar   +1 more source

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +1 more source

The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery

Frontiers in Molecular Biosciences, 2023
Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins, various functions, and unique lipid and protein compositions have been introduced as versatile tools for diagnostic and therapeutic medical applications. Numerous
Samaneh Ghadami, K. Dellinger
semanticscholar   +1 more source

Microencapsulation technology by nature: Cell derived extracellular vesicles with therapeutic potential

, 2013
Cell derived extracellular vesicles are submicron structures surrounded by phospholipid bilayer and released by both prokaryotic and eukaryotic cells.
E. Buzás, A. Falus, Á. Kittel, Buzás, E., Kittel, Ágnes, Falus, A.   +5 more
core   +1 more source

NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

Frontiers in Immunology
Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic ...
Bo Shi, Caolingzhi Tang, Stephanie F. Rutter, Omar Audi, Dilara C. Ozkocak, Alice M. Trenerry, Daniel S. Simpson, Scott A. Williams, Quan T. Le, Gemma F. Ryan, Ponsuge T. M. Cooray, James E. Vince, Jason M. Mackenzie, Mark D. Hulett, Thanh Kha Phan, Ivan K. H. Poon   +15 more
doaj   +1 more source

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

Journal of Extracellular Vesicles, 2021
In this study we tested whether a protein corona is formed around extracellular vesicles (EVs) in blood plasma. We isolated medium‐sized nascent EVs of THP1 cells as well as of Optiprep‐purified platelets, and incubated them in EV‐depleted blood plasma ...
Eszter Á. Tóth, Lilla Turiák, T. Visnovitz, C. Cserép, A. Mázló, Barbara W. Sódar, András I. Försönits, G. Petővári, A. Sebestyén, Z. Komlósi, L. Drahos, Á. Kittel, G. Nagy, A. Bácsi, Á. Dénes, Y. Gho, K. Szabó-Taylor, E. Buzás   +17 more
semanticscholar   +1 more source

Single‐vesicle imaging and co‐localization analysis for tetraspanin profiling of individual extracellular vesicles

, 2021
Extracellular vesicles (EVs) are secreted nano-sized vesicles that contain cellular proteins, lipids, and nucleic acids. Although EVs are expected to be biologically diverse, current analyses cannot adequately characterize this diversity because most are
Kang, H., Yongmin Kwon, Jingeol Lee, Johan Yi, Kang, M., Jaehun Jung, Lee, H., Lee, J., Yi, J., Chungmin Han, Minsu Kang, Jung, J., Park, J., Jaesung Park, Hyejin Kang, Han, C., Hyunjin Lee, Kwon, Y.   +17 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role of Notch pathway in the pro-tumorigenic activity of extracellular vesicles in multiple myeloma [PDF]

, 2021
Introduction: Multiple myeloma (MM) is characterized by the tight interaction between MM cells and bone barrow (BM) niche, resulting in tumor progression.
Domenica Giannandrea, Natalia Platonova, Mara Mazzola, Valentina Citro, Michela Colombo, Raffaella Adami, Raffaella Chiaramonte, Mauro Turrini, Ilaria Giusti, Valentina Bollati, Anna Pistocchi, Vincenza Dolo, Laura Cantone   +12 more
core   +1 more source

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Scientific Reports
Traditional investigations of viral infection mechanisms have predominantly relied on two-dimensional (2D) cell culture models, which lack the structural organization and physiological relevance of native tissues.
Yi-Wen Chen, Huan-Jung Chiang, Kuan-Ting Liu, Chun-Wei Kao, Shan-Ren Xie, Chao-Ming Su, Yu-Yin Shih   +6 more
doaj   +1 more source