Results 41 to 50 of about 385,200 (307)

Boosting extracellular vesicle secretion

Biotechnology Advances, 2022
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID-19, as well as promoting tissue regeneration in various conditions, including cardiomyopathies and spinal cord injuries.
Debbi, Lior, Guo, Shaowei, Safina, Dina, Levenberg, Shulamit   +3 more
openaire   +2 more sources

Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain [PDF]

, 2018
The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells (NPCs) that continuously produce neuroblasts throughout life.
Pastor Loro, Ángel Manuel, Rodríguez Matarredona, Esperanza, Talaverón Aguilocho, Rocío   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Scientific Reports
Traditional investigations of viral infection mechanisms have predominantly relied on two-dimensional (2D) cell culture models, which lack the structural organization and physiological relevance of native tissues.
Yi-Wen Chen, Huan-Jung Chiang, Kuan-Ting Liu, Chun-Wei Kao, Shan-Ren Xie, Chao-Ming Su, Yu-Yin Shih   +6 more
doaj   +1 more source

The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson’s disease

Frontiers in Cellular Neuroscience
Parkinson’s disease is a pathology with a wide range of in vivo and in vitro models available. Among these, the SH-SY5Y neuroblastoma cell line is one of the most employed.
Angel Carvajal-Oliveros, Camila Román-Martínez, Enrique Reynaud, Eduardo Martínez-Martínez   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Metalloproteinases in extracellular vesicles

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communications in local and distant microenvironments under patho/physiological conditions. EVs contain bioactive materials such as proteins, RNA transcripts, microRNAs and even DNAs, and recent work on their protein profiles has revealed the existence of metalloproteinases
Masayuki, Shimoda, Rama, Khokha
openaire   +2 more sources

The endocytosis gene END3 is essential for the glucose-induced rapid decline of small vesicles in the extracellular fraction in Saccharomyces cerevisiae [PDF]

, 2014
Background: Protein secretion is a fundamental process in all living cells. Gluconeogenic enzymes are secreted when Saccharomyces cerevisiae are grown in media containing low glucose.
Bennett J. Giardina, Hui-Ling Chiang, Kathryn Stein   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Nutritional properties of extracellular vesicle-like particles from Sophora flavescens and Periplaneta americana with effects on streptozotocin-induced diabetic wound healing in rats

Frontiers in Nutrition
IntroductionThe medicinal plant Sophora flavescens (SF) and the insect Periplaneta americana (PA) have long been used in treating diabetic wounds. PA-derived extracellular vesicle-like particles (PA-EVLP) can accelerate diabetic wound healing.
Zhengting Wu, Zhengting Wu, Zhengting Wu, Yuanxin Zhao, Yuanxin Zhao, Yuanxin Zhao, Weiyin Zeng, Weiyin Zeng, Weiyin Zeng, Zesheng Lu, Zesheng Lu, Zesheng Lu, Qi You, Qi You, Qi You, Yingqi Cao, Yingqi Cao, Yingqi Cao, Yuanyuan Xia, Yuanyuan Xia, Wencong Shen, Wencong Shen, Wencong Shen, Zilin Ou, Zilin Ou, Zilin Ou, Xiuping Cai, Xiuping Cai, Qing Zhao, Qing Zhao, Qing Zhao, Kewei Zhao, Kewei Zhao, Kewei Zhao   +33 more
doaj   +1 more source