Results 61 to 70 of about 798,647 (298)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Extracellular Vesicles of Neutrophils [PDF]

Immune Network, 2018
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be categorized into 2 subtypes according to the mechanism of generation.
openaire   +2 more sources

Nutritional properties of extracellular vesicle-like particles from Sophora flavescens and Periplaneta americana with effects on streptozotocin-induced diabetic wound healing in rats

Frontiers in Nutrition
IntroductionThe medicinal plant Sophora flavescens (SF) and the insect Periplaneta americana (PA) have long been used in treating diabetic wounds. PA-derived extracellular vesicle-like particles (PA-EVLP) can accelerate diabetic wound healing.
Zhengting Wu, Zhengting Wu, Zhengting Wu, Yuanxin Zhao, Yuanxin Zhao, Yuanxin Zhao, Weiyin Zeng, Weiyin Zeng, Weiyin Zeng, Zesheng Lu, Zesheng Lu, Zesheng Lu, Qi You, Qi You, Qi You, Yingqi Cao, Yingqi Cao, Yingqi Cao, Yuanyuan Xia, Yuanyuan Xia, Wencong Shen, Wencong Shen, Wencong Shen, Zilin Ou, Zilin Ou, Zilin Ou, Xiuping Cai, Xiuping Cai, Qing Zhao, Qing Zhao, Qing Zhao, Kewei Zhao, Kewei Zhao, Kewei Zhao   +33 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles [PDF]

, 2022
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field.
Lenassi Metka, Borràs Francesc E., Clayton Aled, Klein John, Sánchez Catherine, Koritzinsky Erik H., Hill Andrew F., Oeyen Eline, Burger Dylan, Erdbrügger Uta, van Steijn Volkert, Musante Luca, Knepper Mark A., Luther James M., Jimenez Connie R., Falcón-Pérez Juan M., Bijnsdorp Irene V., Martens-Uzunova Elena S., Blijdorp Charles J., Holthöfer Harry, Mertens Inge, Jenster Guido, Bussolati Benedetta, Leivo Janne, Yuen Peter S.T., Thongboonkerd Visith, Dear James W., Verhaegh Gerald, Soekmadji Carolina, Zheng Lei, Puhka Maija, Byrd James Brian, Witwer Kenneth, Hoorn Ewout J., Llorente Alicia, Grange Cristina, van Royen Martin E., Junker Kerstin, Webber Jason P.   +38 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Immunotherapeutic Potential of Extracellular Vesicles [PDF]

Frontiers in Immunology, 2014
Extracellular vesicle or EV is a term that encompasses all classes of secreted lipid membrane vesicles. Despite being scientific novelties, EVs are gaining importance as a mediator of important physiological and pathological intercellular activities possibly through the transfer of their cargo of protein and RNA between cells.
Bin eZhang, Yijun eYin, Ruenn Chai eLai, Sai Kiang eLim, Sai Kiang eLim   +4 more
openaire   +3 more sources

Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation

Nature Communications
SARS-CoV-2 typically utilises host receptor angiotensin-converting enzyme 2 (ACE2) for viral entry. Despite low ACE2 expression, monocyte-derived macrophages, the predominant lung macrophage during severe COVID-19, are often found with SARS-CoV-2 in ...
Thanh Kha Phan, Dylan Sheerin, Bo Shi, Ngee K. Chua, Sriram Gummadi, Merle Dayton, Liana Mackiewicz, Ana Maluenda, Dilara C. Ozkocak, Georgia K. Atkin-Smith, Nashied Peton, Ching-Seng Ang, Omar Audi, Quan Thinh Le, Thu Uyen Tran, Tuong-Khanh My Tu, Rochelle Tixeira, George W. Ashdown, Kathryn C. Davidson, Pamali Fonseka, Rebecca Feltham, Marcel Doerflinger, Mark D. Hulett, Anna K. Coussens, Ivan K. H. Poon   +24 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source