Results 71 to 80 of about 798,647 (298)

The future of Extracellular Vesicles as Theranostics- an ISEV meeting report

, 2020
The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on 'EVs in Clinical Theranostic'.
Yang, Fuquan, Huang, Yiyao, Yan, Xiaomei, Liu, Chunchen, Yin, Hang, Song Gho, Yong, Zheng, Lei, Le, Minh T.N., Marcilla Díaz, Antonio, Zou, Xue, Shekari, Faezeh, Falcón-Perez, Juan Manuel, Wang, Haifang, Cheung, Lesley, Xiao, Yu, An, Taixue, Soekmadji, Carolina, Li, Bo, Wang, Qian, O'Driscoll, Lorraine, Shen, Tang Long, Torrecilhas, Ana Claudia, Zhao, Zezhou, Holthofer, Harry B., Pan, Weilun, Chen, Jing   +25 more
core   +2 more sources

Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus

Cardiovascular Diabetology
Background Gestational diabetes mellitus (GDM) affects 2–20% of pregnant women worldwide and is linked to fetal overgrowth, increased perinatal morbidity, and mortality, as well as a higher risk of developing cardiovascular disease later in life for ...
Nanthini Jayabalan, Soumyalekshmi Nair, Andrew Lai, Katherin Scholz-Romero, Melissa Razo-Azamar, Valeska Ormazabal, Ratana Lim, Flavio Carrion, Dominic Guanzon, Gregory E. Rice, Harold David McIntyre, Martha Lappas, Carlos Salomon   +12 more
doaj   +1 more source

Considerations for the Analysis of Small Extracellular Vesicles in Physical Exercise

Frontiers in Physiology, 2020
Physical exercise induces acute physiological changes leading to enhanced tissue cross-talk and a liberation of extracellular vesicles (EVs) into the circulation.
Alexandra Brahmer, Alexandra Brahmer, Elmo W. I. Neuberger, Perikles Simon, Eva-Maria Krämer-Albers   +4 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Development of a four-gene prognostic signature for hepatocellular carcinoma using TCGA and GEO datasets

Discover Oncology
Background Hepatocellular carcinoma (HCC) poses a major global health challenge due to its high mortality and recurrence, necessitating continuous research into biomarkers for better diagnosis and treatment. Methods Gene expression and clinical data from
Wanhong Gu, Weiwei Chen, Yaqiong Zhang, Xiaoyuan Yan, Ouyang Zhang, Peijie Wang   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Therapeutic Potential of Extracellular Vesicles [PDF]

Frontiers in Immunology, 2014
Extracellular vesicles (EV) have emerged as important mediators of intercellular communication. By their origin, we can find vesicles derived from plasma membrane such as microvesicles, ectosomes, and membrane particles or exosomes, which originate in the endosomal membrane compartment.
Merino, Ana, Hoogduijn, Martin Johannes, Borràs i Serres, Francesc Enric, Franquesa, Marcella   +3 more
openaire   +3 more sources

Extracellular Vesicle‐Based miRNA Profiling in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Secondary Analysis of the MULTISITE Clinical Trial

Journal of Extracellular Biology
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the worldwide leading cause of liver‐related mortality with a prevalence of 75% among individuals with obesity and lacking screenings tools. Extracellular vesicles (EVs)‐based microRNAs (
Katja Lund Cliff, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Gunna Christiansen, Aase Handberg, Carlos Salomon, Maiken Mellergaard   +7 more
doaj   +1 more source