Results 71 to 80 of about 1,214,978 (300)

A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles

Journal of Extracellular Vesicles, 2021
Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal
Y. Couch, E. Buzás, D. D. Vizio, Y. Gho, P. Harrison, A. Hill, J. Lötvall, G. Raposo, P. Stahl, C. Théry, Kenneth W. Witwer, David Carter   +11 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles [PDF]

, 2016
The International Society for Extracellular Vesicles (ISEV) has organised its first educational online course for students and beginners in the field of extracellular vesicles (EVs). This course, “Basics of Extracellular Vesicles,” uses recorded lectures
Lötvall, Jan,, Lötvall, Jan, Mathivanan, Suresh, Lässer, Cecilia, Théry, Clotilde, Buzás, E.I., Mathivanan, S., Lötval, J., Buzás, Edit I, Yong Song Gho, Lässer, C., Zhao, Weian, Gho, Yong Song, Zhao, W., Gho, Yong Song,, Edit I. Buzás, Jan Lötvall, Lässer, Cecilia,, Gho, Y.S., Suresh Mathivanan, Weian Zhao, Théry, C., Cecilia Lässer, Clotilde Théry   +23 more
core   +1 more source

Extracellular vesicles as human therapeutics: A scoping review of the literature

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are released by all cells and contribute to cell‐to‐cell communication. The capacity of EVs to target specific cells and to efficiently deliver a composite profile of functional molecules have led researchers around the world
Clorinda Fusco, Giusy De Rosa, Ilaria Spatocco, E. Vitiello, C. Procaccini, Chiara Frigé, Valeria Pellegrini, Rosalba La Grotta, R. Furlan, G. Matarese, F. Prattichizzo, P. de Candia   +11 more
semanticscholar   +1 more source

Clinical Translation of Extracellular Vesicles

Advanced Healthcare Materials, 2023
Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent attraction as natural materials due to their bioactive surfaces, internal cargo, and role in intercellular communication.
A. Ghodasara, A. Raza, Joy Wolfram, C. Salomon, A. Popat   +4 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Overview and Update on Extracellular Vesicles: Considerations on Exosomes and Their Application in Modern Medicine

Biology, 2022
Simple Summary Exosomes are a subpopulation of extracellular vesicles, nanosized particles, lipid bilayer-enclosed, naturally secreted from cells after the fusion of intracellular Multivesicular bodies with the plasma membrane.
M. A. Di Bella
semanticscholar   +1 more source

Extracellular vesicles, RNA sequencing, and bioinformatic analyses: Challenges, solutions, and recommendations

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are heterogeneous entities secreted by cells into their microenvironment and systemic circulation. Circulating EVs carry functional small RNAs and other molecular footprints from their cell of origin, and thus have evident ...
Rebecca T. Miceli, Tzu-yi Chen, Yohei Nose, Swapnil Tichkule, Brian D. Brown, J. Fullard, Marilyn D. Saulsbury, Simone O. Heyliger, Sacha Gnjatic, N. Kyprianou, Carlos Cordon-Cardo, Susmita Sahoo, Emanuela Taioli, P. Roussos, Gustavo Stolovitzky, Edgar Gonzalez-Kozlova, Navneet Dogra   +16 more
semanticscholar   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source