Results 91 to 100 of about 798,647 (298)

Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Nature Communications
Extracellular vesicles (EVs) hold great potential as a therapeutic delivery system for cancer treatment. Here, we develop an innovative targeted drug delivery platform, human leukocyte antigen-G-VHH antibody-modified EV (α-HLA-G-EV), to enhance ...
Ming-You Shie, Shi-Wei Huang, Yeh Chen, Mei-Chih Chen, Chih-Ming Pan, Cheng-Yu Chen, Yen-Hong Lin, Min-Hua Yu, Kai-Wen Kan, Shao-Chih Chiu, Hui-Chun Ho, Yi-Wen Chen, Der-Yang Cho   +12 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Isolation of Extracellular Vesicles from Stem Cells

, 2017
Transplanted induced pluripotent stem cells (IPSC) and embryonic stem cells (ESC) exhibit enhanced survival in ischemic tissues and promote survival of neighboring cells via paracrine effects.
Liu, Yutao, Yutao Liu, Kim, Il-Man, Neal L. Weintraub, Weintraub, Neal L., Chengwei Ju, Tang, Yaoliang, Genshan Ma, Il-man Kim, Yaoliang Tang, Ju, Chengwei, Hong Yu, Yongjun Li, Li, Yongjun, Zixin Chen, Yu, Hong, Yan Shen, Chen, Zixin, Shen, Yan, Ma, Genshan   +19 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2‐MyD88‐NF‐κB Signalling in NK Cells

Journal of Extracellular Vesicles
Systemic lupus erythematosus (SLE) has been linked to gut microbiome dysbiosis, notably an overabundance of Streptococcus anginosus; however, the impact of this microbial imbalance on disease pathogenesis remains unclear.
Ying Gong, Lingyue Jin, Lina Duan, Jie Xiao, Yao Li, HongXia Wang, Haifang Wang, Wanying Lin, Yi Zhang, Xiufeng Gan, Shuyin Pang, Yurong Qiu, Weinan Lai, Lei Zheng, Haixia Li   +14 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress. [Elektronisk resurs]

, 2013
Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue ...
Belting, Mattias,, Kucharzewska, Paulina,, Lund University.   +2 more
core   +1 more source

Understanding extracellular vesicles [PDF]

PROTEOMICS, 2021
David W. Greening, Richard J. Simpson
openaire   +2 more sources

Coronavesicle-engineered hydrogel sequential photothermal-immunometabolic therapy reprograms tissue microenvironment for diabetic-infected wounds healing

Journal of Nanobiotechnology
Persistent infection and dysregulated tissue microenvironment constitute the primary obstacles hindering the healing of infectious diabetic wounds. Herein, we developed an NIR-responsive hydrogel dressing incorporating polyphenol-engineered plant-derived
Bodeng Wu, Shan Lin, Qi Xiu, Mingzhen Zhong, Yiyao Huang, Zhenxun Wang, Xiuhua Wu, Jiangang Mei, Shuhan Liu, Liping Liu, Bo Li, Weilun Pan, Lei Zheng   +12 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source