Results 81 to 90 of about 1,214,978 (300)

3D-printed magnesium/strontium-co-doped calcium silicate scaffolds promote angiogenesis and bone regeneration through synergistic bioactive ion stimulation

Journal of Biological Engineering
Bone defects resulting from trauma, infection, or surgical resection require biomaterials that support osteogenesis and vascularization for effective regeneration.
Chia-Che Ho, Tuan-Ti Hsu, Yung-Cheng Chiu, Yen-Hong Lin, Pei-Cheng Xie, Chen-Ying Wang   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Isolation of Extracellular Vesicles from Stem Cells

, 2017
Transplanted induced pluripotent stem cells (IPSC) and embryonic stem cells (ESC) exhibit enhanced survival in ischemic tissues and promote survival of neighboring cells via paracrine effects.
Liu, Yutao, Yutao Liu, Kim, Il-Man, Neal L. Weintraub, Weintraub, Neal L., Chengwei Ju, Tang, Yaoliang, Genshan Ma, Il-man Kim, Yaoliang Tang, Ju, Chengwei, Hong Yu, Yongjun Li, Li, Yongjun, Zixin Chen, Yu, Hong, Yan Shen, Chen, Zixin, Shen, Yan, Ma, Genshan   +19 more
core   +1 more source

Bon appétit, your phagocyte

Cell Death Discovery
Every day, billions of cells in the human body undergo apoptosis as part of normal tissue turnover. The swift clearance of these dying cells by phagocytes is an essential process to limit the release of intracellular contents that can disrupt tissue ...
Dilara C. Ozkocak, Jascinta P. Santavanond, Maria C. Tanzer, Ivan K. H. Poon   +3 more
doaj   +1 more source

Antibody-displaying extracellular vesicles for targeted cancer therapy

Nature Biomedical Engineering
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological signals across tissues. Here, by leveraging these functionalities, we show that EVs decorated with an antibody-binding moiety specific for the fragment ...
O. Wiklander, Doste R. Mamand, D. K. Mohammad, Wenyi Zheng, Rim Jawad Wiklander, T. Sych, A. Zickler, Xiuming Liang, H. Sharma, Andrea Lavado, Jeremy P Bost, Samantha Roudi, Giulia Corso, Angus J Lennaárd, Manuchehr Abedi-Valugerdi, Imre Mäger, E. Alici, E. Sezgin, J. Nordin, Dhanu Gupta, Andre Görgens, S. El Andaloussi   +21 more
semanticscholar   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles.

Pharmacological Research
Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication.
Siyu Hao, Hongyu Yang, Jiaojiao Hu, Lili Luo, Yuan Yuan, Libing Liu   +5 more
semanticscholar   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Nature Communications
Extracellular vesicles (EVs) hold great potential as a therapeutic delivery system for cancer treatment. Here, we develop an innovative targeted drug delivery platform, human leukocyte antigen-G-VHH antibody-modified EV (α-HLA-G-EV), to enhance ...
Ming-You Shie, Shi-Wei Huang, Yeh Chen, Mei-Chih Chen, Chih-Ming Pan, Cheng-Yu Chen, Yen-Hong Lin, Min-Hua Yu, Kai-Wen Kan, Shao-Chih Chiu, Hui-Chun Ho, Yi-Wen Chen, Der-Yang Cho   +12 more
doaj   +1 more source

The role and applications of extracellular vesicles in osteoporosis

Bone Research
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture, which increases patient susceptibility to fragile fractures. The intricate mechanisms governing bone homeostasis are substantially
Fei Fang, Jie Yang, Jiahe Wang, Tiantian Li, Erxiang Wang, Demao Zhang, Xiaoheng Liu, Chenchen Zhou   +7 more
semanticscholar   +1 more source