Results 81 to 90 of about 798,647 (298)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Extracellular Vesicles and Metastasis

Cold Spring Harbor Perspectives in Medicine, 2019
Secretion of cell contents through extracellular vesicles (EVs), such as exosomes and microvesicles, is a fundamental cell behavior. Compared with their normal counterparts, cancer cells are different in the amount and composition of EVs they secrete as a result of intrinsic and extrinsic (microenvironmental) alterations.
openaire   +4 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Purification Protocols for Extracellular Vesicles [PDF]

, 2017
This chapter provides a description of some of the standard methods used for the isolation of extracellular vesicles (EVs) from a variety of biological fluids, including cell culture media, urine, plasma and serum. The methods presented include ultracentrifugation, ultrafiltration, proprietary polymer-based reagents, size exclusion chromatography ...
Lane, Rebecca E., Korbie, Darren, Trau, Matt, Hill, Michelle M.   +3 more
openaire   +4 more sources

3D-printed magnesium/strontium-co-doped calcium silicate scaffolds promote angiogenesis and bone regeneration through synergistic bioactive ion stimulation

Journal of Biological Engineering
Bone defects resulting from trauma, infection, or surgical resection require biomaterials that support osteogenesis and vascularization for effective regeneration.
Chia-Che Ho, Tuan-Ti Hsu, Yung-Cheng Chiu, Yen-Hong Lin, Pei-Cheng Xie, Chen-Ying Wang   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles [PDF]

, 2014
Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology ...
Sahoo, S, Di Vizio, Dolores, Wauben, MH, Witwer, KW, Buzás, Edit I, Yong Song Gho, Vizio, DD, Mathivanan, S, Wauben, Marca H, Sahoo, Susmita, Igor V. Kurochkin, Fred Hochberg, Gho, YS, Lötvall, J, Lötvall, Jan,, Lötvall, Jan, Witwer, Kenneth W, Théry, Clotilde, B&C BRC-SIB, Hidetoshi Tahara, Strategic Infection Biology, Kenneth W. Witwer, Kurochkin, IV, Marca H. Wauben, Kurochkin, Igor V, LS Celbiologie-Algemeen, Hochberg, F, Gardiner, C, Mathivanan, Suresh, Hochberg, Fred, Dolores Di Vizio, Gho, Yong Song, Buzás, EI, Gardiner, Christopher, Edit I. Buzás, Christopher Gardiner, Biology of Reproductive Cells, Tahara, Hidetoshi, Hill, Andrew F, Andrew F. Hill, Peter Quesenberry, Susmita Sahoo, Quesenberry, Peter, Hill, AF, Quesenberry, P, Théry, C, Gho, Yong Song,, Di Vizio, D, Jan Lötvall, Tahara, H, Suresh Mathivanan, Clotilde Théry   +51 more
core   +1 more source

Bon appétit, your phagocyte

Cell Death Discovery
Every day, billions of cells in the human body undergo apoptosis as part of normal tissue turnover. The swift clearance of these dying cells by phagocytes is an essential process to limit the release of intracellular contents that can disrupt tissue ...
Dilara C. Ozkocak, Jascinta P. Santavanond, Maria C. Tanzer, Ivan K. H. Poon   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Metabolomics Applied to the Study of Extracellular Vesicles [PDF]

, 2019
Cell-secreted extracellular vesicles (EVs) have rapidly gained prominence as sources of biomarkers for non-invasive biopsies, owing to their ubiquity across human biofluids and physiological stability.
Charles Williams, Siljander, Pia R-M, Siljander, Pia R.-M., Juan M. Falcón-Pérez, Reichardt, Niels-Christian, Niels-Christian Reichardt, Williams, Charles, Palviainen, Mari, Falcon-Perez, Juan M., Mari Palviainen, Pia R.-M. Siljander   +10 more
core   +1 more source