Results 111 to 120 of about 798,647 (298)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A beginner's guide to study extracellular vesicles in human blood plasma and serum

Blood is the most commonly used body fluid for obtaining and studying extracellular vesicles (EVs). While blood is a standard choice for clinical analysis, using blood as a source of EVs introduces multiple layers of complexity.
Siljander, Pia R-M, Nieuwland, Rienk
core   +1 more source

Quantitative proteomic analysis of trypsin‐treated extracellular vesicles to identify the real‐vesicular proteins

, 2020
Extracellular vesicles (EVs) are nano-sized vesicles surrounded by a lipid bilayer and released into the extracellular milieu by most of cells. Although various EV isolation methods have been established, most of the current methods isolate EVs with ...
Seon‐Min Park, Go, Gyeongyun, Choi, Dongsic, Jaewook Lee, Di Vizio, Dolores, Dae‐Kyum Kim, Gyeongyun Go, Dolores Di Vizio, Yong Song Gho, Park, Seon-Min, Gho, Yong Song, Dongsic Choi, Lee, Jaewook, Kim, Dae-Kyum   +13 more
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre-Synapse and Promote Synaptic Pruning

C1q is released by microglia, localizes on weak synapses and acts as a tag for microglial synaptic pruning. However, how C1q tags synapses during the pruning period remains to be fully elucidated.
Barone, Cristiana, Verderio C., Saraceno C., Battocchio, Elisabetta, Colombo S. F., Gabrielli, Martina, Paolicelli, Rosa Chiara, Battocchio E., Azzoni E., Saraceno, Claudia, D'Arrigo G., Azzoni, Emanuele, Cutugno G., Barone C., Golia M. T., Gabrielli M., D'Arrigo, Giulia, Sironi F., Bellini S., Cutugno, Giulia, Frigerio, Roberto, Gagni P., Bendotti, Caterina, Sironi, Francesca, Gagni, Paola, Paolicelli R. C., Cretich, Marina, Lombardi, Marta, Ghidoni R., Ghidoni, Roberta, Colombo, Sara Francesca, Bellini, Sonia, Golia, Maria Teresa, Lombardi M., Cretich M., Verderio, Claudia, Bendotti C., Frigerio R.   +37 more
core   +1 more source

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Journal of Extracellular Vesicles
Ovarian cancer remains the most lethal gynaecological malignancy, largely due to late‐stage diagnosis and the limited sensitivity of CA‐125 for borderline and low‐grade tumours.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon   +11 more
doaj   +1 more source

Circulating extracellular vesicle miRNAs for distinguishing prostate cancer from benign prostatic hyperplasia [PDF]

ExRNA
Aim: Our previous studies identified three extracellular vesicle derived microRNAs (miR-92a-1-5p, miR-375 and miR-148a-3p) potentially associated with prostate cancer (PCa), particularly in advanced stages such as bone-metastatic PCa. This study aimed to
Ting Ding, Xin Zhang, Lijuan Yu
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Beyond basic characterization and omics : Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases.
Oxvig, Claus,, Kari, Otto K., Kari, Otto, Masood Kamali‐Moghaddam, Federico, Antonio,, Siljander, Pia R.M., Rikke Halse Østergaard, Kamali-Moghaddam, Masood,, Laitinen, Saara, Eble, Johannes A., Kjaer-Sorensen, Kasper, Hayashi, Yuya, Kasper Kjaer‐Sorensen, Joseph Ndika, Palviainen, Mari, Greco, Dario,, Juan M. Falcon‐Perez, Mari Palviainen, Laitinen, Saara,, Saara Laitinen, Palviainen, Mari,, Claus Oxvig, Aransay, Ana M.,, Federico, Antonio, Maaninka, Katariina, Ana M. Aransay, Falcon-Perez, Juan M., Katariina Maaninka, Pia R.‐M. Siljander, Kamali-Moghaddam, Masood, Aransay, Ana M., Eble, Johannes A.,, Halse Østergaard, Rikke,, Falcon-Perez, Juan M.,, Eble, Johannes, Butt, Umar, Butt, Umar,, Østergaard, Rikke Halse, Greco, Dario, Umar Butt, Oxvig, Claus, Ndika, Joseph,, Kjaer-Sorensen, Kasper,, Johannes A. Eble, Dario Greco, Ndika, Joseph, Johanna Puutio, Puutio, Johanna, Puutio, Johanna,, Ostergaard, Rikke, Yuya Hayashi, Kari, Otto K.,, Otto K. Kari, Antonio Federico, Siljander, Pia, Aransay, Ana, Hayashi, Yuya,, Maaninka, Katariina,, Halse Østergaard, Rikke, Siljander, Pia R. -M., Siljander, Pia R. -M.,   +60 more
core   +1 more source