Results 121 to 130 of about 385,200 (307)

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Immunogenicity of Extracellular Vesicles

Advanced Materials
AbstractExtracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (beyond the apparent lack of immunotoxicity) to advance clinical development.
Yutian Xia, Jianzhong Zhang, Gang Liu, Joy Wolfram   +3 more
openaire   +2 more sources

Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier

Interdisciplinary Medicine
Intercellular communication across the maternal‐fetal barrier is essential for maintaining physiological balance during pregnancy. As the structural foundation of the maternal‐fetal barrier, the placenta is the core site for material exchange and ...
Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng   +5 more
doaj   +1 more source

Performance evaluation of four antibiotics using the BD Phoenix™ NMIC-413 antimicrobial susceptibility testing panel for carbapenem-resistant Enterobacteriaceae and carbapenem-resistant Pseudomonas aeruginosa

Frontiers in Microbiology
BackgroundThe spread of antimicrobial resistance (AMR) poses significant threats to human health. In 2024, the World Health Organization (WHO) classified carbapenem-resistant Enterobacteriaceae (CRE) as a critical-priority pathogen and carbapenem ...
Yajuan Guan, Yajuan Guan, Zhenli Song, Yanshan Chen, Yanshan Chen, Jiayu Feng, Jiayu Feng, Yizhi Fan, Yongyu Rui, Yongyu Rui   +9 more
doaj   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease

Frontiers in Physiology
Chronic kidney disease (CKD) poses a significant health burden worldwide. Especially, obesity-induced chronic kidney disease (OCKD) is associated with a lack of accuracy in disease diagnostic methods.
Nahuel Aquiles Garcia, Hernan Gonzalez-King, Maiken Mellergaard, Maiken Mellergaard, Soumyalekshmi Nair, Carlos Salomon, Aase Handberg, Aase Handberg   +7 more
doaj   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Extracellular Vesicles Containing MDP Derived from Lactobacillus rhamnosus GG Inhibit HSV‐2 Infection by Activating the NOD2‐IFN‐I Signalling Pathway

Journal of Extracellular Vesicles
The immune evasion strategies and lifelong latency of herpes simplex virus type 2 (HSV‐2) present significant challenges for effective treatment. Recent studies have demonstrated that the commensal microbiota plays an important role in regulating ...
Jingyu Wang, Haoming Chen, Mei Huang, Yuqi Du, Ruyi Zhang, Yiyi Huang, Yuling Lin, Ruoru Pan, Yubing Wang, Wanqin Cui, Qian Wang, Lei Zheng, Xiumei Hu   +12 more
doaj   +1 more source

Extracellular vesicle miRNAs from three-dimensional ovarian cancer in vitro models and their implication in overall cancer survival

Heliyon
Ovarian cancer is the most common gynaecological malignancy and the seventh most diagnosed cancer in females worldwide. Currently, it is the sixth leading cause of cancer related mortality among patients globally.
Nihar Godbole, Andrew Lai, Flavio Carrion, Katherin Scholz-Romero, Akhilandeshwari Ravichandran, Priyakshi Kalita-de Croft, Amy E. McCart Reed, Vaibhavi Joshi, Sunil R. Lakhani, Mostafa Kamal Masud, Yusuke Yamauchi, Lewis Perrin, John Hooper, Laura Bray, Dominic Guanzon, Carlos Salomon   +15 more
doaj   +1 more source