Results 101 to 110 of about 1,172,315 (295)

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Exosomes and Exosomal miRNA in Respiratory Diseases [PDF]

, 2016
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and ...
Adcock, IM, Alipoor, SD, Garssen, J, Mirsaeidi, M, Mortaz, E, Movassaghi, M   +5 more
core   +4 more sources

Size‐exclusion chromatography‐based enrichment of extracellular vesicles from urine samples [PDF]

, 2015
Inés Lozano‐Ramos, Ioana Bancu, Anna Oliveira‐Tercero, María Pilar Armengol, Armando Menezes‐Neto, Hernando A. del Portillo, Ricardo Lauzurica‐Valdemoros, Francesc E. Borràs   +7 more
openalex   +1 more source

Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer′s disease: progress, advantages, and challenges

, 2022
RenataGuedes de Jesus Gonçalves, JulianaFerreira Vasques, AlmirJordão da Silva-Junior, Fernanda Gubert, Rosalia Méndez‐Otero   +4 more
openalex   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair [PDF]

, 2011
Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of plasma membrane disruptions. Before resealing, the torn membrane is submitted to considerable tension, which functions to expand the disruption.
A Brisson, A Brisson, AK McNeil, B Brachvogel, B Brachvogel, B Brachvogel, B Jeppesen, C Cai, C Cai, C Pigault, C Vénien-Bryan, CE Creutz, CJ Merrifield, D Bansal, D Bansal, D Voges, EB Babiychuk, F D'Acquisto, F Oling, F Oling, G Mosser, GQ Bi, HA Andree, I Reviakine, J Liu, JH Rand, K Balasubramanian, K Monastyrskaya, L Glover, M Menke, M Rodahl, MA Kaetzel, MA Swairjo, MP Sheetz, NJ Lennon, NO Concha, NO Concha, O Lambert, O Saurel, PL McNeil, PL McNeil, PL McNeil, Q Ling, R Bérat, R Huber, R Huber, R Langen, R Richter, RA Steinhardt, RP Richter, S Yasuda, SE Moss, T Skrahina, T Togo, T Yeung, V Gerke, Y Mo   +56 more
core   +2 more sources

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Stem cells and extracellular vesicles: biological regulators of physiology and disease [PDF]

, 2019
Theodor Borgovan, Lorin Crawford, Chibuikem Nwizu, Peter J. Quesenberry   +3 more
openalex   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Extracellular vesicles as a next-generation drug delivery platform

Nature Nanotechnology, 2021
I. Herrmann, M. J. Wood, G. Fuhrmann
semanticscholar   +1 more source