Results 181 to 190 of about 798,647 (298)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Do Extracellular Vesicles and the Biochemical Microenvironment Contribute to Amyloid Transthyretin Cardiomyopathy? [PDF]

JACC Adv
Franzini M, Greco F, Musetti V, Emdin M.
europepmc   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

Correction: Nutritional properties of extracellular vesicle-like particles from Sophora flavescens and Periplaneta americana with effects on streptozotocin-induced diabetic wound healing in rats

Frontiers in Nutrition
Zhengting Wu, Zhengting Wu, Zhengting Wu, Yuanxin Zhao, Yuanxin Zhao, Yuanxin Zhao, Weiyin Zeng, Weiyin Zeng, Weiyin Zeng, Zesheng Lu, Zesheng Lu, Zesheng Lu, Qi You, Qi You, Qi You, Yingqi Cao, Yingqi Cao, Yingqi Cao, Yuanyuan Xia, Yuanyuan Xia, Wencong Shen, Wencong Shen, Wencong Shen, Zilin Ou, Zilin Ou, Zilin Ou, Xiuping Cai, Xiuping Cai, Qing Zhao, Qing Zhao, Qing Zhao, Kewei Zhao, Kewei Zhao, Kewei Zhao   +33 more
doaj   +1 more source

Extracellular Vesicles in Breast Cancer: Immunomodulation, Biomarkers, and Therapy. [PDF]

Int J Nanomedicine
Wang X, Chen H, Yang M, Chen P, Kang H, Wang F, Huang J, Ding T.   +7 more
europepmc   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Oncolytic Virus-Engineered Extracellular Vesicles Rewire Glioblastoma Immunity. [PDF]

J Extracell Vesicles
Kiel K, Balakrishnan A, Cabaj A, Stanaszek L, Przybylski M, Stępnik D, Małuszek M, Jannotta C, Linke CZ, Suszyńska-Zajczyk J, Knaur M, Szczypiorowska A, Hryhorowicz S, Świderska B, Piwocka K, Ling AL, Chiocca EA, Bronisz A, Godlewski J.   +18 more
europepmc   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Platelet-related extracellular vesicles: Therapeutic roles in musculoskeletal disorders. [PDF]

Regen Ther
Meng T, Wang Y, Tang X, Xiong J, Hu S.
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source