Results 161 to 170 of about 1,214,978 (300)

Depletion of soluble cytokines unlocks the immunomodulatory bioactivity of extracellular vesicles

, 2023
Despite an enormous interest in understanding the bioactivity of extracellular vesicles (EV) in physiology and disease for the development of therapeutic applications, the impact of EV preparation methods remains minimally explored.
Pinheiro, CláudioGE380001715964348020028538560000-0003-1834-199XD69009EA-2324-11E8-91EE-0E5512A95AF2, Hendrix, AnGE380020003830058010020440300000-0002-1883-8309F7EB1496-F0ED-11E1-A9DE-61C894A0A6B4, Roux, Quentin000171596636802002853957975695724408D6702DD2-2324-11E8-91EE-0E5512A95AF2, Tkach, Mercedes, De Wever, OlivierGE380019942973648010013720030000-0002-5453-760XF5D0FA72-F0ED-11E1-A9DE-61C894A0A6B4, De Geyter, SofieGE38802000477356FBB4C860-F0ED-11E1-A9DE-61C894A0A6B4, Thery, Clotilde, De Vuyst, FelixGE380001608828838020037960690000-0003-2364-750470F47306-786B-11E6-815E-A870B5D1D7B1, Miinalainen, Ilkka, Boiy, RobinGE38WE140001600537378020029961240000-0002-6296-9103878E90BC-957E-11E6-8F77-B134B5D1D7B1   +9 more
core  

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source

Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A

Journal of Extracellular Biology
Placental extracellular vesicles (EVs) can be found in the maternal circulation throughout gestation, and their concentration, content and bioactivity are associated with pregnancy outcomes, including gestational diabetes mellitus (GDM).
Carlos Palma, Andrew Lai, Katherin Scholz‐Romero, Haarika Chittoory, Benjamin Van Haeringen, Flavio Carrion, Aase Handberg, Martha Lappas, Sunil R Lakhani, Amy E McCart Reed, H. David McIntyre, Soumyalekshmi Nair, Carlos Salomon   +12 more
doaj   +1 more source

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Nature Biomedical Engineering, 2023
Yi You, Yu Tian, Zhaogang Yang, Junfeng Shi, K. Kwak, Yuhao Tong, Andreanne Poppy Estania, Jianhong Cao, Wei-Hsiang Hsu, Yutong Liu, Chi-Ling Chiang, B. Schrank, Kristin M. Huntoon, DaeYong Lee, Ziwei Li, Yarong Zhao, Huan Zhang, Thomas D Gallup, Jonghoon Ha, Shiyan Dong, Xuefeng Li, Yifan Wang, Wen-jing Lu, Eman Bahrani, L. Lee, Lesheng Teng, Wen Jiang, Feng Lan, Betty Y. S. Kim, Andrew S. Lee   +29 more
semanticscholar   +1 more source

Hierarchical Structure and Fabrication of Functionally Graded Biointerfaces in the Mussel Byssus

Advanced Materials Interfaces, EarlyView.
The byssus is a fibrous protein‐based holdfast consisting of mechanically distinct interfaces, which mussels use to anchor their soft living tissue to hard seashore surfaces. Here, multiscale methodologies were used to elucidate the compositional and structural features underlying these functionally graded interfaces and how they are fabricated through
Lucia Youssef, Jenaes Sivasundarampillai, Sydney Mikulin, Franziska Jehle, Matthew J. Harrington   +4 more
wiley   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

Innovative approach to the detection of circulating tumor biomarkers: multi-dimensional application of liposome technology

Lipids in Health and Disease
Malignant tumors represent a significant worldwide health challenge, with elevated morbidity and mortality rates necessitating enhanced early identification and individualized treatment.
Weichu Tan, Yitong Zhu, Siting Chen
doaj   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Association of a five-metabolite and early-symptom profile with Parkinson’s disease and its clinical progression

Scientific Reports
Parkinson’s disease (PD) urgently requires blood-based markers that flag pathology before disabling motor decline. This study measured absolute concentrations of 144 plasma metabolites in 20 neurologically healthy adults and in 40 PD patients clinically ...
Juan José Oropeza Valdez, José Pedro Elizalde-Díaz, Osbaldo Resendis Antonio, Jaquelin Leyva -Hernández, Laura Adalid-Peralta, Mayela Rodríguez-Violante, Rupasri Mandal, David S. Wishart, Yamilé López-Hernández, Eduardo Martínez -Martínez   +9 more
doaj   +1 more source