Results 151 to 160 of about 1,214,978 (300)

Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells

Advanced Materials, EarlyView.
This study demonstrates plasmonic enhancement of the function of fluorescent voltage sensing proteins (genetically encoded voltage indicators, (GEVIs), QuasAr6) in live mammalian cells. Coupling to plasmonic nanoparticles does not just increase fluorescence, but influences the protein photocycle, creating a hybrid sensor with its response speed to ...
Marco Locarno, Qiangrui Dong, Marco Post, Xin Meng, Cristiano Glessi, Nynke Marije Hettema, Nidas Brandsma, Sebbe Blokhuizen, Alejandro Castañeda Garcia, Srividya Ganapathy, Thieme Schmidt, Lars van Roemburg, Bing Xu, Chun‐Ting Cho, Liedewij Laan, Miao‐Ping Chien, Daan Brinks   +16 more
wiley   +1 more source

Extracellular Vesicles Containing MDP Derived from Lactobacillus rhamnosus GG Inhibit HSV‐2 Infection by Activating the NOD2‐IFN‐I Signalling Pathway

Journal of Extracellular Vesicles
The immune evasion strategies and lifelong latency of herpes simplex virus type 2 (HSV‐2) present significant challenges for effective treatment. Recent studies have demonstrated that the commensal microbiota plays an important role in regulating ...
Jingyu Wang, Haoming Chen, Mei Huang, Yuqi Du, Ruyi Zhang, Yiyi Huang, Yuling Lin, Ruoru Pan, Yubing Wang, Wanqin Cui, Qian Wang, Lei Zheng, Xiumei Hu   +12 more
doaj   +1 more source

Attempt to Identify Extracellular Vesicles Derived From the Blood-Brain Barrier in Peripheral Blood

Journal of Trial and Error
The blood-brain barrier (BBB) is hypothesized to play a role in the pathophysiology of psychosis. However, studying this structure in living humans is challenging due to limitations in current methods that fail to identify subtle changes or dysfunctions.
Mette Elise Tunset, Francis Combes, Hanne Haslene-Hox   +2 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Intracellular localisation and extracellular release of Y RNA and Y RNA binding proteins [PDF]

Cells can communicate via the release and uptake of extracellular vesicles (EVs), which are nano-sized membrane vesicles that can transfer protein and RNA cargo between cells.
Tran Ngoc Minh, Thi, Buck, Amy H, Driedonks, Tom A P, Ressel, Sarah, Nolte-'t Hoen, Esther N M   +4 more
core  

DNA analysis of low‐ and high‐density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology

, 2019
Extracellular vesicles have the capacity to transfer lipids, proteins, and nucleic acids between cells, thereby influencing the recipient cell's phenotype.
García-Rodríguez, Anaís,, Lötvall, Jan,, Shelke, Ganesh V,, Crescitelli, Rossella,, Cvjetkovic, Aleksander,, Jang, Su Chul,, Su Chul Jang, Elisa Lázaro‐Ibáñez, Aleksander Cvjetkovic, Jan Lötvall, Lässer, Cecilia,, Anaís García‐Rodríguez, Rossella Crescitelli, Lázaro-Ibáñez, Elisa,, Cecilia Lässer, Ganesh Vilas Shelke   +15 more
core   +1 more source

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

Advanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk, Eylul Gulsen Yilmaz, Yusuf Aslan, Emre Ece, Özgecan Erdem, Murat Alp Gungen, Bengi Özgün Öztürk, Fatih Inci   +7 more
wiley   +1 more source

Plant-derived nanovesicles from Ginkgo biloba seeds mitigate LPS-induced endothelial dysfunction and promote vascular homeostasis

Frontiers in Bioengineering and Biotechnology
BackgroundEndothelial dysfunction is increasingly recognized as an early and central event in the onset of cardiovascular and neurodegenerative diseases.
Maneea Moubarak, Emese Szilágyi-Tolnai, Ani Barbulova, Immacolata Fiume, Ildikó Kovács-Forgács, Judit Homoki, Georgina Pesti-Asbóth, Endre Szilágyi, Ramila Mammadova, Matic Kisovec, Marjetka Podobnik, Dávid Papp, Gitta Schlosser, Judit Remenyik, Gabriella Pocsfalvi   +14 more
doaj   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in SARS-CoV-2 and H1N1 influenza-induced acute lung injury

Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have shown anti-inflammatory potential in multiple inflammatory diseases. In the March 2022 issue of the Journal of Extracellular Vesicles, it was shown that EVs from human MSCs can ...
Lötvall, Jan,, Cho, Byong Seung, Lee, Jun Ho, Jeon, Hyungtaek   +3 more
core   +1 more source