Results 171 to 180 of about 798,647 (298)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

MicroRNA profile of circulating extracellular vesicles are associated with upregulation of neuroinflammatiory signalling pathway in aged animals

, 2020
Freishtat, R., Batabyal, Rachael, Siqueira, Ionara Rodrigues, Bastos, Catherina Isdra Moszkowicz, Cechinel, Laura Reck   +4 more
core   +1 more source

Mechanism of Autophagic Extracellular Vesicles Revealed. [PDF]

Traffic
Demetriades C, Galli T.
europepmc   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Recommendations for Studying In Situ Extracellular Vesicles From Solid Tissue

Solid tissue-derived extracellular vesicles (ST-EVs) are extracellular vesicles (EVs) separated directly from solid tissues of both vertebrates and invertebrates.
Huang, Yiyao, Hendrix, An, Paolini, Lucia, Levy, Efrat, Crescitelli, Rossella, Hill, Andrew F., Puig, Berta, Vella, Laura J., Hurwitz, Stephanie N., Ikezu, Tsuneya   +9 more
core   +1 more source

Extracellular Vesicles in Neonatology: Have We Found the Magic Bullet? [PDF]

Biology (Basel)
Papadogeorgou P, Tsantes AG, Valsami S, Fortis SP, Kriebardis AG, Mougiou V, Iliodromiti Z, Boutsikou T, Iacovidou N, Sokou R.   +9 more
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

In situ detection of extracellular vesicles in breast cancer

Extracellular vesicles (EVs) are small vesicles secreted by a variety of cells into the extracellular space. The role of EVs in cancer biology is well established. It's been reported that EVs-mediated intercellular communication can promote cell growth
Pekovic-Vaughan, Vanja, Korać, Bato, Stojanović, Sara, Golić, Igor, Zakić, Tamara, Korać, Aleksandra, Čvoro, Aleksandra, Janković, Aleksandra   +7 more
core  

Bacterial extracellular vesicles as central mediators of microbiota-host communication. [PDF]

Front Microbiol
Oktem Okullu S, Akcelik-Deveci S, Buyukcolak-Cebeci Y, Gokduman SN, Sele G.   +4 more
europepmc   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source