Results 41 to 50 of about 247,554 (291)

Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice [PDF]

, 2023
Anna Schmid, Agnieszka Razim, Magdalena Wysmołek, Daniela Kerekes, Melissa Haunstetter, Paul Kohl, Georgii Brazhnikov, Nora Geissler, Michael Thaler, Eliška Krčmářová, Martin Šindelář, Tamara Weinmayer, Jiří Hrdý, Katy Schmidt, Peter Nejsum, Bradley Whitehead, Johan Palmfeldt, Stefan Schild, Aleksandra Inić‐Kanada, Ursula Wiedermann, Irma Schabussová   +20 more
openalex   +1 more source

Extracellular Vesicles in Angiogenesis

Circulation Research, 2017
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important players in cell-to-cell communication in normal physiology and pathological conditions. EVs encapsulate and convey various bioactive molecules that are further transmitted to neighboring or more distant cells ...
Todorova, Dilyana, Simoncini, Stéphanie, Lacroix, Romaric, Sabatier, Florence, Dignat-George, Françoise   +4 more
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus

Cardiovascular Diabetology
Background Gestational diabetes mellitus (GDM) affects 2–20% of pregnant women worldwide and is linked to fetal overgrowth, increased perinatal morbidity, and mortality, as well as a higher risk of developing cardiovascular disease later in life for ...
Nanthini Jayabalan, Soumyalekshmi Nair, Andrew Lai, Katherin Scholz-Romero, Melissa Razo-Azamar, Valeska Ormazabal, Ratana Lim, Flavio Carrion, Dominic Guanzon, Gregory E. Rice, Harold David McIntyre, Martha Lappas, Carlos Salomon   +12 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Bridging the extracellular vesicle knowledge gap: insights from non-mammalian vertebrates, invertebrates, and early-diverging metazoans

Frontiers in Cell and Developmental Biology, 2023
Extracellular vesicles (EVs) are lipid-enclosed structures that facilitate intercellular communication by transferring cargo between cells. Although predominantly studied in mammals, extracellular vesicles are ubiquitous across metazoans, and thus ...
Michaela Liegertová, Olga Janoušková
doaj   +1 more source

Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann–Pick Type C Disease [PDF]

, 2021
Lien Van Hoecke, Caroline Van Cauwenberghe, Verena Börger, Arnout Bruggeman, Jonas Castelein, Griet Van Imschoot, Elien Van Wonterghem, Robin Dittrich, Wouter Claeys, Junhua Xie, Bernd Giebel, Roosmarijn E. Vandenbroucke   +11 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

3D-printed magnesium/strontium-co-doped calcium silicate scaffolds promote angiogenesis and bone regeneration through synergistic bioactive ion stimulation

Journal of Biological Engineering
Bone defects resulting from trauma, infection, or surgical resection require biomaterials that support osteogenesis and vascularization for effective regeneration.
Chia-Che Ho, Tuan-Ti Hsu, Yung-Cheng Chiu, Yen-Hong Lin, Pei-Cheng Xie, Chen-Ying Wang   +5 more
doaj   +1 more source

Extracellular vesicles and aging [PDF]

Stem Cell Investigation, 2017
Aging and the chronic diseases associated with aging place a tremendous burden on our healthcare system. As our world population ages dramatically over the next decades, this will only increase. Hence, there is a great need to discover fundamental mechanisms of aging to enable development of strategies for minimizing the impact of aging on our health ...
openaire   +2 more sources