Results 61 to 70 of about 1,172,315 (295)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34) [PDF]

, 2014
Introduction: There is renewed interest in extracellular vesicles over the past decade or 2 after initially being thought of as simple cellular garbage cans to rid cells of unwanted components.
Christopher McGee, Grant A. Robinson, Renee Rawson, Roger D. Madison   +3 more
core   +1 more source

Extracellular vesicles through the blood–brain barrier: a review

Fluids and Barriers of the CNS, 2022
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain ...
H. Ramos-Zaldívar, Iva Polakovičová, E. Salas-Huenuleo, A. Corvalán, M. Kogan, Claudia P. Yefi, M. Andía   +6 more
semanticscholar   +1 more source

Advances in Platelet Rich Plasma-Derived Extracellular Vesicles for Regenerative Medicine: A Systematic-Narrative Review [PDF]

, 2023
Eduardo Anitua, María Troya, Juan Manuel Falcón‐Pérez, Silvia López-Sarrio, Esperanza González, Mohammad Hamdan Alkhraisat   +5 more
openalex   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Cardiac Extracellular Vesicles (EVs) Released in the Presence or Absence of Inflammatory Cues Support Angiogenesis in Different Manners [PDF]

, 2019
Cells release extracellular vesicles (EVs) to communicate in a paracrine manner with other cells, and thereby influence processes, such as angiogenesis.
Beez, Christien Madlen, Haag, Marion, Linthout, Sophie Van, Pappritz, Kathleen, Schneider, Maria, Seifert, Martina, Sittinger, Michael   +6 more
core   +1 more source

A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation

Journal of Extracellular Vesicles, 2022
Nanoparticles can acquire a plasma protein corona defining their biological identity. Corona functions were previously considered for cell‐derived extracellular vesicles (EVs).
Martin Wolf, R. Poupardin, Patricia Ebner-Peking, André Cronemberger Andrade, C. Blöchl, A. Obermayer, F. G. Gomes, Balázs Vári, Nicole Maeding, Essi Eminger, H. Binder, A. Raninger, S. Hochmann, Gabriele Brachtl, A. Spittler, T. Heuser, R. Ofir, C. Huber, Z. Aberman, K. Schallmoser, H. Volk, D. Strunk   +21 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]

, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi, Angelo Sarra, Barbara Ruzicka, Carmela Serpe, Cristina Limatola, Cristina Limatola, Francesca Guerrieri, Giancarlo Ruocco, Giuseppe Familiari, Giuseppe Rubens Pascucci, Giuseppina Chece, Michela Relucenti, Myriam Catalano, Myriam Catalano, Valentina Nigro   +14 more
core   +5 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source